Wikipedia

EP300

Histon-acetiltransferaza p300, znana i kao p300 HAT ili E1A-vezani protein p300 (gdje je E1A = adenovirusna rana regija 1A) također poznat kao i kao EP300 ili p300, jest enzim koji je kod ljudi kodiran genom EP300 sa hromosoma 22.[5] Funkcioniše kao histon-acetiltransferaza koja reguliše transkripciju gena putem remodeliranja hromatina, dozvoljavajući histonskim proteinima da manje čvrsto omotaju DNK. Ovaj enzim ima esencijalnu ulogu u regulaciji ćelijskog rasta i diobe, podstičući ćelije da sazrijevaju i preuzmu specijalizirane funkcije (diferencijacije), te sprječavaju rast kancerogenih tumora. Čini se da je protein p300 kritičan za normalan razvoj prije i nakon rođenja.

EP300
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

1L3E, 1P4Q, 2K8F, 2MH0, 2MZD, 3BIY, 3I3J, 3IO2, 3P57, 3T92, 4BHW, 4PZR, 4PZS, 4PZT, 5BT3

Identifikatori
AliasiEP300
Vanjski ID-jeviOMIM: 602700 MGI: 1276116 HomoloGene: 1094 GeneCards: EP300
Lokacija gena (čovjek)
Hromosom 22 (čovjek)
Hrom.Hromosom 22 (čovjek)[1]
Hromosom 22 (čovjek)
Genomska lokacija za EP300
Genomska lokacija za EP300
Bend22q13.2Početak41,092,592 bp[1]
Kraj41,180,077 bp[1]
Lokacija gena (miš)
Hromosom 15 (miš)
Hrom.Hromosom 15 (miš)[2]
Hromosom 15 (miš)
Genomska lokacija za EP300
Genomska lokacija za EP300
Bend15|15 E1Početak81,469,552 bp[2]
Kraj81,536,278 bp[2]
Obrazac RNK ekspresije


Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija• protein C-terminus binding
• transcription factor binding
• GO:0001104 transcription coregulator activity
• vezivanje iona metala
• acyltransferase activity
• aktivnost sa transferazom
• beta-catenin binding
• pre-mRNA intronic binding
• vezivanje iona cinka
• chromatin binding
• oštećeno vezivanje sa DNK
• GO:0001948, GO:0016582 vezivanje za proteine
• acetyltransferase activity
• vezivanje sa DNK
• GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific
• GO:0001105 transcription coactivator activity
• p53 binding
• androgen receptor binding
• chromatin DNA binding
• histone acetyltransferase activity
• lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
• peptide N-acetyltransferase activity
• peptide-lysine-N-acetyltransferase activity
• protein propionyltransferase activity
• STAT family protein binding
• peptide butyryltransferase activity
• histone crotonyltransferase activity
• histone butyryltransferase activity
• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Ćelijska komponenta• jedro
• histone acetyltransferase complex
• transcription regulator complex
• nukleoplazma
• citoplazma
• citosol
• hromosom
Biološki proces• somitogenesis
• rhythmic process
• transcription by RNA polymerase II
• histone H2B acetylation
• animal organ morphogenesis
• ćelijski ciklus
• B cell differentiation
• GO:0097285 apoptoza
• GO:0009373 regulation of transcription, DNA-templated
• lung development
• N-terminal peptidyl-lysine acetylation
• platelet formation
• stimulatory C-type lectin receptor signaling pathway
• transcription, DNA-templated
• GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
• heart development
• regulation of transcription from RNA polymerase II promoter in response to hypoxia
• GO:0022415 viral process
• protein acetylation
• Notch signaling pathway
• cellular response to UV
• protein stabilization
• positive regulation of DNA-binding transcription factor activity
• GO:1901227 negative regulation of transcription by RNA polymerase II
• nervous system development
• regulation of autophagy
• regulation of androgen receptor signaling pathway
• positive regulation of protein binding
• positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
• fat cell differentiation
• positive regulation by host of viral transcription
• megakaryocyte development
• intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
• internal protein amino acid acetylation
• regulation of cell cycle
• regulation of tubulin deacetylation
• GO:1901313 positive regulation of gene expression
• histone H4 acetylation
• regulation of cellular response to heat
• transcription-coupled nucleotide-excision repair
• skeletal muscle tissue development
• positive regulation of type I interferon production
• response to estrogen
• response to hypoxia
• regulation of signal transduction by p53 class mediator
• internal peptidyl-lysine acetylation
• beta-catenin-TCF complex assembly
• DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
• macrophage derived foam cell differentiation
• Jednodnevni biološki ritam
• protein deubiquitination
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
• protein destabilization
• regulation of megakaryocyte differentiation
• histone acetylation
• epigenetic maintenance of chromatin in transcription-competent conformation
• peptidyl-lysine propionylation
• peptidyl-lysine crotonylation
• peptidyl-lysine butyrylation
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

2033

328572

Ensembl

ENSG00000100393

ENSMUSG00000055024

UniProt

Q09472

B2RWS6

RefSeq (mRNK)

NM_001429
NM_001362843

NM_177821

RefSeq (bjelančevina)

NP_001420
NP_001349772

NP_808489

Lokacija (UCSC)Chr 22: 41.09 – 41.18 MbChr 15: 81.47 – 81.54 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Gen EP300 se nalazi na dugom (q) kraku ljudskog hromosoma 22 na poziciji 13.2. Ovaj gen kodira adenovirusni E1A povezan sa ćelijskim p300 transkripcijskim koaktivatorskim proteinom.

EP300 je blisko povezan sa drugim genom, CREB vezujući protein, koji se nalazi na ljudskom hromosomu 16.

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 2.414 aminokiselina, a molekulska težina 264.161 Da.

1020304050
MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINS
TELGLTNGGDINQLQTSLGMVQDAASKHKQLSELLRSGSSPNLNMGVGGP
GQVMASQAQQSSPGLGLINSMVKSPMTQAGLTSPNMGMGTSGPNQGPTQS
TGMMNSPVNQPAMGMNTGMNAGMNPGMLAAGNGQGIMPNQVMNGSIGAGR
GRQNMQYPNPGMGSAGNLLTEPLQQGSPQMGGQTGLRGPQPLKMGMMNNP
NPYGSPYTQNPGQQIGASGLGLQIQTKTVLSNNLSPFAMDKKAVPGGGMP
NMGQQPAPQVQQPGLVTPVAQGMGSGAHTADPEKRKLIQQQLVLLLHAHK
CQRREQANGEVRQCNLPHCRTMKNVLNHMTHCQSGKSCQVAHCASSRQII
SHWKNCTRHDCPVCLPLKNAGDKRNQQPILTGAPVGLGNPSSLGVGQQSA
PNLSTVSQIDPSSIERAYAALGLPYQVNQMPTQPQVQAKNQQNQQPGQSP
QGMRPMSNMSASPMGVNGGVGVQTPSLLSDSMLHSAINSQNPMMSENASV
PSLGPMPTAAQPSTTGIRKQWHEDITQDLRNHLVHKLVQAIFPTPDPAAL
KDRRMENLVAYARKVEGDMYESANNRAEYYHLLAEKIYKIQKELEEKRRT
RLQKQNMLPNAAGMVPVSMNPGPNMGQPQPGMTSNGPLPDPSMIRGSVPN
QMMPRITPQSGLNQFGQMSMAQPPIVPRQTPPLQHHGQLAQPGALNPPMG
YGPRMQQPSNQGQFLPQTQFPSQGMNVTNIPLAPSSGQAPVSQAQMSSSS
CPVNSPIMPPGSQGSHIHCPQLPQPALHQNSPSPVPSRTPTPHHTPPSIG
AQQPPATTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQPS
LPAAPSADQPQQQPRSQQSTAASVPTPTAPLLPPQPATPLSQPAVSIEGQ
VSNPPSTSSTEVNSQAIAEKQPSQEVKMEAKMEVDQPEPADTQPEDISES
KVEDCKMESTETEERSTELKTEIKEEEDQPSTSATQSSPAPGQSKKKIFK
PEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSPMDLS
TIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFE
QEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQNRYHF
CEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELFVECTEC
GRKMHQICVLHHEIIWPAGFVCDGCLKKSARTRKENKFSAKRLPSTRLGT
FLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKPGMKARFVDSGEMA
ESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDS
VHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPPSEGDDYIFHC
HPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDYKDIFKQATEDRLTSAKE
LPYFEGDFWPNVLEESIKELEQEEEERKREENTSNESTDVTKGDSKNAKK
KNNKKTSKNKSSLSRGNKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRL
IAGPAANSLPPIVDPDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWS
TMCMLVELHTQSQDRFVYTCNECKHHVETRWHCTVCEDYDLCITCYNTKN
HDHKMEKLGLGLDDESNNQQAAATQSPGDSRRLSIQRCIQSLVHACQCRN
ANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQENK
CPVPFCLNIKQKLRQQQLQHRLQQAQMLRRRMASMQRTGVVGQQQGLPSP
TPATPTTPTGQQPTTPQTPQPTSQPQPTPPNSMPPYLPRTQAAGPVSQGK
AAGQVTPPTPPQTAQPPLPGPPPAAVEMAMQIQRAAETQRQMAHVQIFQR
PIQHQMPPMTPMAPMGMNPPPMTRGPSGHLEPGMGPTGMQQQPPWSQGGL
PQPQQLQSGMPRPAMMSVAQHGQPLNMAPQPGLGQVGISPLKPGTVSQQA
LQNLLRTLRSPSSPLQQQQVLSILHANPQLLAAFIKQRAAKYANSNPQPI
PGQPGMPQGQPGLQPPTMPGQQGVHSNPAMQNMNPMQAGVQRAGLPQQQP
QQQLQPPMGGMSPQAQQMNMNHNTMPSQFRDILRRQQMMQQQQQQGAGPG
IGPGMANHNQFQQPQGVGYPPQQQQRMQHHMQQMQQGNMGQIGQLPQALG
AEAGASLQAYQQRLLQQQMGSPVQPNPMSPQQHMLPNQAQSPHLQGQQIP
NSLSNQVRSPQPVPSPRPQSQPPHSSPSPRMQPQPSPHHVSPQTSSPHPG
LVAAQANPMEQGHFASPDQNSMLSQLASNPGMANLHGASATDLGLSTDNS
DLNSNLSQSTLDIH

Funkcija

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p300 HAT funkcionira kao histon-acetiltransferaza[6] koji regulira transkripciju putem remodeliranja hromatina i važan je u procesima proliferacije i diferencijacije ćelija. Posreduje u regulaciji cAMP-gena, tako što se specifično vezuje za fosforilizirani CREB protein.

p300 HAT sadrži bromodomain koji je uključen u IL6 signalizaciju.[7]:3.1

Ovaj gen je također identificiran kao koaktivator HIF1A (faktor 1 alfa induciran hipoksijom), te stoga ima ulogu u stimulaciji gena izazvanih hipoksijom, kao što je VEGF.[8]

Mehanizam

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Protein p300 obavlja svoju funkciju aktivacije transkripcije vezivanjem za transkripcijski faktor i transkripcijski mehanizam. Na osnovu ove funkcije, p300 se naziva transkripcijski koaktivator. Interakcijom p300 sa faktorima transkripcije upravlja jedan ili više p300 domena: jedarni receptorski domen interakcije (RID), KIX domen (CREB i MYB domen interakcije), cistein/histidin regije (TAZ1/CH1 i TAZ2/CH3) i interferonski domen za vezivanje odgovora (IBiD). Posljednja četiri domena, KIX, TAZ1, TAZ2 i IBiD od p300, svaki se čvrsto vezuje za sekvencu koja obuhvata oba trasaltivacijska domena 9aaTAD faktora transkripcije p53.[9]

Klinički značaj

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Mutacije u genu EP300 odgovorne su za mali procent slučajeva Rubinstein-Taybijevog sindroma. Ove mutacije rezultiraju gubitkom jedne kopije gena u svakoj ćeliji, što smanjuje količinu p300 proteina za polovinu. Neke mutacije dovode do proizvodnje vrlo kratke, nefunkcionalne verzije proteina p300, dok druge sprječavaju da jedna kopija gena uopće napravi bilo koji protein. Iako se ne zna kako smanjenje količine p300 proteina dovodi do specifičnih karakteristika Rubinstein-Taybijevog sindroma, jasno je da gubitak jedne kopije gena EP300 remeti normalan razvoj.

Preuređenje hromosoma koji uključuje hromosom 22 rijetko je povezano s određenim tipovima raka. Ova preuređivanja, zvana translokacije, remete regiju hromosoma 22 koji sadrži gen EP300. Naprimjer, nađena je translokaciju između hromosoma 8 i 22 kod nekoliko ljudi s rakom krvnih ćelija pod nazivom akutna mijeloidna leukemija (AML). Još jedna translokacija, koja uključuje hromosome 11 i 22, pronađena je kod malog broja ljudi koji su bili podvrgnuti liječenju raka. Ova hromosomska promjena povezana je s razvojem AML-a nakon hemoterapija za druge oblike raka.

Mutacije u genu EP300 identificirane su u nekoliko drugih tipova raka. Ove mutacije su somatske, što znači da se stiču tokom života osobe i prisutne su samo u određenim ćelijama. Somatske mutacije u genu EP300 pronađene su u malom broju solidnih tumora, uključujući karcinom debelog crijeva i rektuma, želuca, dojke i [ [rak gušterače|gušterače]]. Studije sugeriraju da mutacije EP300 također mogu imati ulogu u razvoju nekih karcinoma prostate i mogu pomoći u predviđanju da li će se ovi tumori povećati dimenzije ili proširiti na druge dijelove tijela. U ćelijama raka, mutacije EP300 sprečavaju gen da proizvodi bilo koji funkcionalni protein. Bez p300, ćelije ne mogu efikasno obuzdati rast i podjelu, što može omogućiti nastanak kanceroznih tumora.

Interakcije

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Pokazalo se da EP300 reaguje sa:

Reference

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Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

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