Wikipedia

ESR1

(Preusmjereno sa Estrogeni receptor alfa)

Estrogeni receptor alfa (ERα), znan i kao NR3A1 (član 1grupe A potporodice jedarnih receptora), jedan je od dva tipa estrogenih receptora, jedarni receptor koji se aktivira spolnim hormonom estrogenom. Kod ljudi kodiran genom ESR1 (Estrogeni receptor 1).[5][6][7]

ESR1
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

1A52, 1ERE, 1ERR, 1G50, 1GWQ, 1GWR, 1HCP, 1HCQ, 1L2I, 1PCG, 1QKT, 1QKU, 1R5K, 1SJ0, 1UOM, 1X7E, 1X7R, 1XP1, 1XP6, 1XP9, 1XPC, 1XQC, 1YIM, 1YIN, 1ZKY, 2AYR, 2B1V, 2B1Z, 2B23, 2BJ4, 2FAI, 2G44, 2G5O, 2I0J, 2IOG, 2IOK, 2JF9, 2JFA, 2LLO, 2LLQ, 2OCF, 2OUZ, 2P15, 2POG, 2Q6J, 2Q70, 2QA6, 2QA8, 2QAB, 2QE4, 2QGT, 2QGW, 2QH6, 2QR9, 2QSE, 2QXM, 2QXS, 2QZO, 2R6W, 2R6Y, 2YAT, 2YJA, 3CBM, 3CBO, 3CBP, 3DT3, 3ERD, 3ERT, 3HLV, 3HM1, 3L03, 3OS8, 3OS9, 3OSA, 3Q95, 3Q97, 3UU7, 3UUA, 3UUC, 3UUD, 4AA6, 4DMA, 4IU7, 4IUI, 4IV2, 4IV4, 4IVW, 4IVY, 4IW6, 4IW8, 4IWC, 4IWF, 4JC3, 4JDD, 4MG5, 4MG6, 4MG7, 4MG8, 4MG9, 4MGA, 4MGB, 4MGC, 4MGD, 4O6F, 4PP6, 4PPP, 4PPS, 4PXM, 4Q13, 4Q50, 4TUZ, 4TV1, 5AK2, 5AAV, 5ACC, 5AAU, 4XI3, 4ZN9, 5FQS, 5FQR, 5FQP, 5FQT, 5FQV, 4ZN7, 5E0W, 5DUG, 4ZUC, 5DXK, 5E19, 5DXQ, 5EI1, 5DXR, 5DVS, 5DZ1, 5E0X, 5DKB, 5DWI, 5E14, 5DXB, 5BPR, 5EIT, 5E15, 4ZNS, 5EGV, 5DL4, 5DWE, 4ZNT, 5EHJ, 5DYD, 5DWG, 4ZNV, 5DWJ, 5DID, 4ZUB, 5BNU, 5DMC, 5DK9, 5DIG, 5DUH, 5DKS, 5DMF, 5DU5, 5DY8, 4ZWH, 5DVV, 5DLR, 4ZWK, 5DRM, 5DP0, 5DKE, 5DZI, 5DZ3, 4ZNU, 5DIE, 5DZ0, 5E1C, 5HYR, 5BQ4, 4ZNW, 5DUE, 5DTV, 5DRJ, 5DKG, 4ZNH, 5BP6, 5DXG, 5DI7, 5DX3, 5DYB, 5DXP, 5DZH, 5DXM

Identifikatori
AliasiESR1
Vanjski ID-jeviOMIM: 133430 MGI: 1352467 HomoloGene: 47906 GeneCards: ESR1
Lokacija gena (čovjek)
Hromosom 6 (čovjek)
Hrom.Hromosom 6 (čovjek)[1]
Hromosom 6 (čovjek)
Genomska lokacija za ESR1
Genomska lokacija za ESR1
Bend6q25.1-q25.2Početak151,656,691 bp[1]
Kraj152,129,619 bp[1]
Lokacija gena (miš)
Hromosom 10 (miš)
Hrom.Hromosom 10 (miš)[2]
Hromosom 10 (miš)
Genomska lokacija za ESR1
Genomska lokacija za ESR1
Bend10 A1|10 2.03 cMPočetak4,561,593 bp[2]
Kraj4,955,614 bp[2]
Ontologija gena
Molekularna funkcija• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
• GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific
• nitric-oxide synthase regulator activity
• GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity
• estrogen response element binding
• transcription factor binding
• vezivanje iona metala
• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• steroid hormone receptor activity
• steroid binding
• beta-catenin binding
• vezivanje iona cinka
• chromatin binding
• GO:0001948, GO:0016582 vezivanje za proteine
• vezivanje sa DNK
• sequence-specific DNA binding
• ATPase binding
• vezivanje identičnih proteina
• lipid binding
• core promoter sequence-specific DNA binding
• vezivanje enzima
• protein kinase binding
• TFIIB-class transcription factor binding
• TBP-class protein binding
• estrogen receptor activity
• estrogen receptor binding
• transcription coactivator binding
• phosphatidylinositol-4,5-bisphosphate 3-kinase activity
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
Ćelijska komponenta• citoplazma
• membrana
• jedro
• integral component of membrane
• Golđijev aparat
• ćelijska membrana
• nukleoplazma
• transcription preinitiation complex
• citosol
• GO:0009327 makromolekulani kompleks
Biološki proces• epithelial cell development
• positive regulation of phospholipase C activity
• mammary gland alveolus development
• transcription by RNA polymerase II
• phospholipase C-activating G protein-coupled receptor signaling pathway
• epithelial cell proliferation involved in mammary gland duct elongation
• prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
• protein localization to chromatin
• steroid hormone mediated signaling pathway
• regulation of apoptotic process
• chromatin remodeling
• GO:0009373 regulation of transcription, DNA-templated
• androgen metabolic process
• positive regulation of fibroblast proliferation
• mammary gland branching involved in pregnancy
• negative regulation of gene expression
• transcription, DNA-templated
• negative regulation of DNA-binding transcription factor activity
• cellular response to estrogen stimulus
• GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
• positive regulation of nitric-oxide synthase activity
• transcription initiation from RNA polymerase II promoter
• regulation of branching involved in prostate gland morphogenesis
• male gonad development
• positive regulation of DNA-binding transcription factor activity
• GO:1901227 negative regulation of transcription by RNA polymerase II
• negative regulation of I-kappaB kinase/NF-kappaB signaling
• negative regulation of production of miRNAs involved in gene silencing by miRNA
• response to estrogen
• uterus development
• prostate epithelial cord elongation
• antral ovarian follicle growth
• vagina development
• positive regulation of cytosolic calcium ion concentration
• positive regulation of nitric oxide biosynthetic process
• GO:0072468 Transdukcija signala
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
• intracellular steroid hormone receptor signaling pathway
• regulation of inflammatory response
• response to estradiol
• regulation of toll-like receptor signaling pathway
• GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
• protein deubiquitination
• cellular response to estradiol stimulus
• intracellular estrogen receptor signaling pathway
• positive regulation of RNA polymerase II transcription preinitiation complex assembly
• stem cell differentiation
• regulation of Wnt signaling pathway
• regulation of intracellular estrogen receptor signaling pathway
• phosphatidylinositol phosphate biosynthetic process
• positive regulation of protein kinase B signaling
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

2099

13982

Ensembl

ENSG00000091831

ENSMUSG00000019768

UniProt

P03372

P19785

RefSeq (mRNK)
NM_000125
NM_001122740
NM_001122741
NM_001122742
NM_001291230

NM_001291241
NM_001328100
NM_001385568
NM_001385569
NM_001385570
NM_001385571
NM_001385572

NM_007956
NM_001302531
NM_001302532
NM_001302533

RefSeq (bjelančevina)
NP_000116
NP_001116212
NP_001116213
NP_001116214
NP_001278159

NP_001278170
NP_001315029

NP_001289460
NP_001289461
NP_001289462
NP_031982

Lokacija (UCSC)Chr 6: 151.66 – 152.13 MbChr 10: 4.56 – 4.96 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 595 aminokiselina, а molekulska težina 66.216 Da.[8]

1020304050
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPA
VYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPL
NSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFY
RPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVW
SCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGM
MKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLA
DRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPG
KLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKS
IILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQ
HQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLH
APTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV

Struktura

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Receptor estrogena (ER) je ligand-aktivirani transkripcijski faktor sastavljen od nekoliko domena važnih za vezivanje hormona, vezanjem i aktivacijom transkripcije.[9] Alternativna prerada rezultira u nekoliko transkripata ESR1 iRNK, koji se prvenstveno razlikuju po pet primarnih neprevedenih regija (UTR5'). Translatirani receptori pokazuju manju varijabilnost.[10][11]

Ligandi

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Agonisti

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Neselektivni

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Selektivni

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Selektivni agonisti ERα u odnosu na ERβ uključuju:

Mješoviti

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Antagonisti

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Neselektivni

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Selektivni

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Selektivni antagonisti ERα u odnosu na ERβ uključuju:

Afiniteti

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Šablon:Afiniteti liganda estrogenog receptora ERα i ERβ

Tkivna distribucija i funkcija

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ERα ima ulogu u fiziološkom razvoju i funkciji različitih organskih sistema u različitom stepenu, uključujući reproduktivni, centralni nervni, skeletni i kardiovaskularni sistem.[12] U skladu s tim, ERα je široko eksprimiran u cijelom tijelu, uključujući tkiva organa kao što su maternica i jajnici, muški reproduktivni organi, mliječne žlijezde, kosti, srce, hipotalamus, hipofiza, jetra, pluća, bubrezi, slezena i masno tkivo .[12][13][14] Razvoj i funkcija ovih tkiva poremećen je u životinjskim modelima bez aktivnih ERα gena, poput ERα nokaut-miša (ERKO), pružajući prethodno razumijevanje funkcije ERα u specifičnim ciljanim organima.[12][15]

Klinički značaj

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Sindrom neosjetljivosti na estrogene je vrlo rijetko stanje koje karakterizira neispravan Erα, neosjetljiv na estrogene.[16][17][18][19] Uočeno je da klinička slika žena uključuje odsustvo razvoja dojke i drugih ženskih sekundarsnih spolnih obilježja u pubertetu, hipoplaziji maternice, primarnoj amenoreji, pri uvećanim policistastim jajnicima i pridruženom bolu u donjem dijelu trbuha, blagi hiperandrogenizam (ispoljava se kao cistaste akne) i odgođeno sazrijevanje kosti kao i povećana stopa koštanog promedta. Klinička slika kod mužjaka je uključivala nedostatak zatvaranja epifize, visok rast, osteoporozu i lošu održivost spermatozoida. Obje posmstrane osobe bile su potpuno neosetljive na egzogeni tretman estrogenom, čak i pri visokim dozama.

Genetički polimorfizmi u genu koji kodira ERα povezani su sa rakom dojke i dismenorejom kod žena, a ginekomastijom kod muškaraca.[20][21][22]

Koaktivatori

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Koaktivatori ER-α uključuju:

Interakcije

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Pokazano je da receptor estrogena alfa stupa u interakcije sa:

Reference

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