Wikipedia

HDAC1

Histon-deacetilaza 1 (HDAC1) jest enzim koji je kod ljudi kodiran genom HDAC1 sa hromosoma 1.[5]

HDAC1
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

4BKX, 5ICN

Identifikatori
AliasiHDAC1
Vanjski ID-jeviOMIM: 601241 MGI: 108086 HomoloGene: 68426 GeneCards: HDAC1
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za HDAC1
Genomska lokacija za HDAC1
Bend1p35.2-p35.1Početak32,292,083 bp[1]
Kraj32,333,635 bp[1]
Lokacija gena (miš)
Hromosom 4 (miš)
Hrom.Hromosom 4 (miš)[2]
Hromosom 4 (miš)
Genomska lokacija za HDAC1
Genomska lokacija za HDAC1
Bend4 D2.2|4 63.26 cMPočetak129,409,897 bp[2]
Kraj129,436,506 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• NAD-dependent histone deacetylase activity (H3-K14 specific)
• GO:0001106 transcription corepressor activity
• histone deacetylase activity
• protein N-terminus binding
• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
• protein deacetylase activity
• histone deacetylase binding
• GO:0000975 transcription cis-regulatory region binding
• NF-kappaB binding
• deacetylase activity
• GO:0001948, GO:0016582 vezivanje za proteine
• nucleosomal DNA binding
• vezivanje enzima
• hydrolase activity
• core promoter sequence-specific DNA binding
• p53 binding
• transcription factor binding
• RNA polymerase II core promoter sequence-specific DNA binding
• vezivanje sa DNK
• chromatin binding
• Krueppel-associated box domain binding
• E-box binding
• promoter-specific chromatin binding
Ćelijska komponenta• citoplazma
• NuRD complex
• citosol
• histone deacetylase complex
• Sin3 complex
• nukleoplazma
• jedro
• Hromatin
• GO:0035328 heterochromatin
• transcription regulator complex
• transcription repressor complex
• GO:0009327 makromolekulani kompleks
• neuronal cell body
• Sin3-type complex
Biološki proces• hair follicle placode formation
• epidermal cell differentiation
• chromatin remodeling
• GO:0009373 regulation of transcription, DNA-templated
• rhythmic process
• negative regulation of androgen receptor signaling pathway
• embryonic digit morphogenesis
• negative regulation of apoptotic process
• Koagulacija (krv)
• GO:1901227 negative regulation of transcription by RNA polymerase II
• eyelid development in camera-type eye
• circadian regulation of gene expression
• negative regulation of gene expression
• GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
• odontogenesis of dentin-containing tooth
• protein deacetylation
• histone H4 deacetylation
• fungiform papilla formation
• negative regulation of myotube differentiation
• GO:0022415 viral process
• histone deacetylation
• negative regulation of canonical Wnt signaling pathway
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
• transcription, DNA-templated
• regulation of signal transduction by p53 class mediator
• DNA methylation-dependent heterochromatin assembly
• beta-catenin-TCF complex assembly
• GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization
• positive regulation of cell population proliferation
• GO:0045996 negative regulation of transcription, DNA-templated
• histone H3 deacetylation
• regulation of megakaryocyte differentiation
• GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
• endoderm development
• Jednodnevni biološki ritam
• hippocampus development
• neuron differentiation
• negative regulation of I-kappaB kinase/NF-kappaB signaling
• positive regulation of oligodendrocyte differentiation
• regulation of endopeptidase activity
• regulation of amyloid-beta clearance
• negative regulation of intrinsic apoptotic signaling pathway
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

3065

433759

Ensembl

ENSG00000116478

ENSMUSG00000028800

UniProt

Q13547

O09106

RefSeq (mRNK)

NM_004964

NM_008228

RefSeq (bjelančevina)

NP_004955

NP_032254

Lokacija (UCSC)Chr 1: 32.29 – 32.33 MbChr 4: 129.41 – 129.44 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 482 aminokiseline, a molekulska težina Da. 55.103[6]

1020304050
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRK
MEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDC
PVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGF
CYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHK
YGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVME
MFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNM
TNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDD
PDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKE
KDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA

4

Funkcija uredi

Acetilacija i deacetilacija histona, katalizirana kompleksima više podjedinica, ima ključnu ulogu u regulaciji eukariotske ekspresije gena. Protein kodiran ovim genom pripada porodici histon deacetilaza/acuc/alfa i komponenta je kompleksa histon-deacetilaza. Također je u interakciji sa proteinom supresorom tumora retinoblastoma i ovaj kompleks je ključni element u kontroli proliferacije i diferencijacije ćelija. Zajedno s proteinom-2 MTA2 povezanim s metastazama, deacetilira p53 i modulira njegov učinak na rast i ćelijsku apoptozu.[7]

Modelni organizmi uredi

Fenotip Hdac1 nokaut-miševa
Svojstvo Fenotip
Vijabilnost homozigot Nenormalan
Studija recesivne letalnosti Nenormalan
Plodnost Normalan
Tjelesna težina Normalan
Anksioznost otvorenog polja Normalan
Neurološka procjena Normalan
Snaga stiska Normalan
Test vruće ploče Normalan
Dismorfologija Normalan
Indirektna kalorimetrija Normalan
Test tolerancije glukoze Normalan
Slušni odgovor moždanog stabla Normalan
DEXA Normalan
Radiografija Normalan
Tjelesna temperatura Normalan
Morfologija oka Normalan
Klinička hemija Normalan
Hematologija Normalan
Limfociti periferne krvi Normalan
Mikronukleus test Normalan
Težina srca Normalan
Histopatologija mozga Normalan
Histopatologija oka Normalan
Salmonella infekcija Normalan[8]
Citrobacter infekcija Normalan[9]
Svi testovi i analize prema[10][11]

U proučavanju funkcije HDAC1 korišteni su modelni organizmi. Uvjetna linija nokaut-miševa, zvana Hdac1tm1a(EUCOMM)Wtsi[12][13] gwnwrirana je kao dio programa Međunarodnog konzorcija za nokaut-miševe — visokoprolpusnog projekta mutageneze za generiranje i distribuciju modela životzinjskih bolesti zainteresiranim naučnicima — na Institutu Wellcome Trust Sanger.[14][15][16] Mužjaci i ženke podvrgnute su standardiziranom fenotipskom pregledu kako bi se utvrdili efekti delecija.[10][17] Obavljeno je 25 testova i prijavljena su dva nenormalna fenotipa. Tokom gestacije identifikovan je smanjen broj homozigotnih mutantnih embriona, a nijedan nije preživio do odbijanja. Preostali testovi su obavljeni na heterozigot nimmutantnim odraslim miševima i kod ovih životinja nisu uočene značajne abnormalnosti.[10]

Interakcije uredi

Pokazalo se da HDAC1 interraguje sa:

Također pogledajte uredi

Reference uredi

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