EZH2

EZH2
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4MI0, 4MI5, 5HYN, 5IJ8, 5IJ7
Identifikatori
Aliasi	EZH2
Vanjski ID-jevi	OMIM: 601573 MGI: 107940 HomoloGene: 37926 GeneCards: EZH2
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	148,884,321 bp
Lokacija gena (miš)
Hrom.	Hromosom 6 (miš)
Kraj	47,595,341 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0102674, GO:0102675 methyltransferase activity; • sequence-specific DNA binding; • aktivnost sa transferazom; • promoter-specific chromatin binding; • chromatin binding; • histone-lysine N-methyltransferase activity; • protein-lysine N-methyltransferase activity; • GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje sa RNK; • ribonucleoprotein complex binding; • chromatin DNA binding; • RNA polymerase II core promoter sequence-specific DNA binding; • primary miRNA binding; • vezivanje sa DNK; • histone methyltransferase activity; • histone methyltransferase activity (H3-K27 specific); • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0001106 transcription corepressor activity;
Ćelijska komponenta	• ESC/E(Z) complex; • pronucleus; • jedro; • nukleoplazma; • citoplazma; • Telomera;
Biološki proces	• regulation of protein phosphorylation; • regulation of gliogenesis; • response to estradiol; • GO:0009373 regulation of transcription, DNA-templated; • positive regulation of MAP kinase activity; • rhythmic process; • negative regulation of retinoic acid receptor signaling pathway; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • negative regulation of striated muscle cell differentiation; • G1 to G0 transition; • GO:1901227 negative regulation of transcription by RNA polymerase II; • positive regulation of dendrite development; • positive regulation of epithelial to mesenchymal transition; • negative regulation of transcription elongation from RNA polymerase II promoter; • transcription, DNA-templated; • negative regulation of DNA-binding transcription factor activity; • positive regulation of protein serine/threonine kinase activity; • negative regulation of gene expression; • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle; • histone H3-K27 methylation; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • Metilacija DNK; • negative regulation of epidermal cell differentiation; • Metilacija; • negative regulation of gene expression, epigenetic; • regulation of cell population proliferation; • regulation of circadian rhythm; • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration; • cerebellar cortex development; • Regulacija ekspresije gena; • GO:0045996 negative regulation of transcription, DNA-templated; • protein localization to chromatin; • hippocampus development; • regulation of neurogenesis; • cellular response to hydrogen peroxide; • response to tetrachloromethane; • cellular response to trichostatin A; • histone H3-K27 trimethylation; • cardiac muscle hypertrophy in response to stress; • hepatocyte homeostasis; • liver regeneration; • Metilacija histona; • negative regulation of G0 to G1 transition; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization; • positive regulation of cell population proliferation; • positive regulation of cell cycle G1/S phase transition;
	Izvori:Amigo / QuickGO
Ortolozi
	2146
	14056
	ENSG00000106462
	ENSMUSG00000029687
	Q15910
	Q61188
	NM_001203247; NM_001203248; NM_001203249; NM_004456; NM_152998
	NM_001146689; NM_007971
	NP_001190176; NP_001190177; NP_001190178; NP_004447; NP_694543
	NP_001140161; NP_031997
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

EGFR-antisens RNK 1 je protein koji je kod ljudi kodiran genom EGFR-AS1.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 746 aminokiselina, а molekulska težina 85.363 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MGQTGKKSEK	GPVCWRKRVK	SEYMRLRQLK	RFRRADEVKS	MFSSNRQKIL
ERTEILNQEW	KQRRIQPVHI	LTSVSSLRGT	RECSVTSDLD	FPTQVIPLKT
LNAVASVPIM	YSWSPLQQNF	MVEDETVLHN	IPYMGDEVLD	QDGTFIEELI
KNYDGKVHGD	RECGFINDEI	FVELVNALGQ	YNDDDDDDDG	DDPEEREEKQ
KDLEDHRDDK	ESRPPRKFPS	DKIFEAISSM	FPDKGTAEEL	KEKYKELTEQ
QLPGALPPEC	TPNIDGPNAK	SVQREQSLHS	FHTLFCRRCF	KYDCFLHPFH
ATPNTYKRKN	TETALDNKPC	GPQCYQHLEG	AKEFAAALTA	ERIKTPPKRP
GGRRRGRLPN	NSSRPSTPTI	NVLESKDTDS	DREAGTETGG	ENNDKEEEEK
KDETSSSSEA	NSRCQTPIKM	KPNIEPPENV	EWSGAEASMF	RVLIGTYYDN
FCAIARLIGT	KTCRQVYEFR	VKESSIIAPA	PAEDVDTPPR	KKKRKHRLWA
AHCRKIQLKK	DGSSNHVYNY	QPCDHPRQPC	DSSCPCVIAQ	NFCEKFCQCS
SECQNRFPGC	RCKAQCNTKQ	CPCYLAVREC	DPDLCLTCGA	ADHWDSKNVS
CKNCSIQRGS	KKHLLLAPSD	VAGWGIFIKD	PVQKNEFISE	YCGEIISQDE
ADRRGKVYDK	YMCSFLFNLN	NDFVVDATRK	GNKIRFANHS	VNPNCYAKVM
MVNGDHRIGI	FAKRAIQTGE	ELFFDYRYSQ	ADALKYVGIE	REMEIP

Funkcija

U jednoj od nedavnih studuja, konstatira se da dugolančane nekodirajuće RNK imaju bitnu ulogu u progresiji raka mokraćnog mjehura i ukazuje da je potrebno je dodatno proučiti ulogu duge nekodirajuće RNK EGFR-AS1 u karcinomu mjehura. Koristili su kliničke uzorke za analizu odnosa između EGFR-AS1 i karakteristika pacijenata s rakom mjehura. Funkcionalni eksperimenti i studije mehanizama izvedeni su pomoću qRT-PCR, transwell testa, analize preživljavanja i korelacijske analize. Otkrili su da je visoka ekspresija EGFR-AS1 gotovo povezana s agresivnim karcinomom mjehura i ukazuje na lošu prognozu za pacijente. Funkcionalni eksperimenti in vivo i in vitro sugerirali su da EGFR-AS1 podstiče proliferaciju i invaziju ćelija raka mjehura. Mehanički, EGFR-AS1 je promovirao ekspresiju EGFR-a inhibiranjem razgradnje EGFR-ove iRNK, čime se podstiče metastaziranje raka mjehura. Osim toga, EGFR-AS1/EGFR može biti uključen u imunološke puteve raka mjehura. Ove studije ukazuju da put EGFR-AS1/EGFR može biti potencijalni dijagnostički marker i terapeutska meta za rak mokraćnog mjehura.^[7]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106462 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029687 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: EGFR antisense RNA 1". Pristupljeno 6. 9. 2016.
^ "UniProt, Q15910" (jezik: engleski). Pristupljeno 23. 9. 2021.
^ Anbang Wang , Aimin Jiang , Xinxin Gan, Zheng Wang , Jinming Huang, Kai Dong, Bing Liu, Linhui Wang, Ming Chen (2020): Affiliations expand EGFR-AS1 Promotes Bladder Cancer Progression by Upregulating EGFR. Biomed Res Int 6665974; pmid: 33426060; pmcid: pmc7781701; doi: 10.1155/2020/6665974

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106462 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029687 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: EGFR antisense RNA 1". Pristupljeno 6. 9. 2016.

[UniProt-6] "UniProt, Q15910" (jezik: engleski). Pristupljeno 23. 9. 2021.

[7] Anbang Wang , Aimin Jiang , Xinxin Gan, Zheng Wang , Jinming Huang, Kai Dong, Bing Liu, Linhui Wang, Ming Chen (2020): Affiliations expand EGFR-AS1 Promotes Bladder Cancer Progression by Upregulating EGFR. Biomed Res Int 6665974; pmid: 33426060; pmcid: pmc7781701; doi: 10.1155/2020/6665974

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