ARID1A

ARID1A
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1RYU
Identifikatori
Aliasi	ARID1A
Vanjski ID-jevi	OMIM: 603024 MGI: 1935147 HomoloGene: 21216 GeneCards: ARID1A
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	26,782,104 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	133,756,769 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • GO:0001105 transcription coactivator activity; • GO:0001948, GO:0016582 vezivanje za proteine; • nuclear receptor binding; • nucleosome binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• nBAF complex; • SWI/SNF complex; • nukleoplazma; • npBAF complex; • jedro; • SWI/SNF superfamily-type complex; • brahma complex;
Biološki proces	• androgen receptor signaling pathway; • chromatin remodeling; • GO:0009373 regulation of transcription, DNA-templated; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • cardiac muscle cell differentiation; • optic cup formation involved in camera-type eye development; • placenta blood vessel development; • GO:1901227 negative regulation of transcription by RNA polymerase II; • toxin transport; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization; • transcription, DNA-templated; • nervous system development; • cardiac chamber development; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • neural tube closure; • nucleosome disassembly; • forebrain development; • intracellular estrogen receptor signaling pathway; • glucocorticoid receptor signaling pathway; • formation of primary germ layer; • Gastrulacija; • embryo implantation; • stem cell population maintenance;
	Izvori:Amigo / QuickGO
Ortolozi
	8289
	93760
	ENSG00000117713
	ENSMUSG00000007880
	O14497
	A2BH40
	NM_139135; NM_006015; NM_018450
	NM_001080819; NM_001363070
	NP_006006; NP_624361
NP_001074288; NP_001349999; NP_001388200; NP_001388202; NP_001388204;
	NP_001388205
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

AT-bogati interaktivni protein 1A sa domenom jest protein koji je kod ljudi kodiran genom ARID1A sa hromosoma 1.^[5]^[6]^[7]

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 2.285 aminokiselina, a molekulska težina 242.045 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAAQVAPAAA	SSLGNPPPPP	PSELKKAEQQ	QREEAGGEAA	AAAAAERGEM
KAAAGQESEG	PAVGPPQPLG	KELQDGAESN	GGGGGGGAGS	GGGPGAEPDL
KNSNGNAGPR	PALNNNLTEP	PGGGGGGSSD	GVGAPPHSAA	AALPPPAYGF
GQPYGRSPSA	VAAAAAAVFH	QQHGGQQSPG	LAALQSGGGG	GLEPYAGPQQ
NSHDHGFPNH	QYNSYYPNRS	AYPPPAPAYA	LSSPRGGTPG	SGAAAAAGSK
PPPSSSASAS	SSSSSFAQQR	FGAMGGGGPS	AAGGGTPQPT	ATPTLNQLLT
SPSSARGYQG	YPGGDYSGGP	QDGGAGKGPA	DMASQCWGAA	AAAAAAAAAS
GGAQQRSHHA	PMSPGSSGGG	GQPLARTPQP	SSPMDQMGKM	RPQPYGGTNP
YSQQQGPPSG	PQQGHGYPGQ	PYGSQTPQRY	PMTMQGRAQS	AMGGLSYTQQ
IPPYGQQGPS	GYGQQGQTPY	YNQQSPHPQQ	QQPPYSQQPP	SQTPHAQPSY
QQQPQSQPPQ	LQSSQPPYSQ	QPSQPPHQQS	PAPYPSQQST	TQQHPQSQPP
YSQPQAQSPY	QQQQPQQPAP	STLSQQAAYP	QPQSQQSQQT	AYSQQRFPPP
QELSQDSFGS	QASSAPSMTS	SKGGQEDMNL	SLQSRPSSLP	DLSGSIDDLP
MGTEGALSPG	VSTSGISSSQ	GEQSNPAQSP	FSPHTSPHLP	GIRGPSPSPV
GSPASVAQSR	SGPLSPAAVP	GNQMPPRPPS	GQSDSIMHPS	MNQSSIAQDR
GYMQRNPQMP	QYSSPQPGSA	LSPRQPSGGQ	IHTGMGSYQQ	NSMGSYGPQG
GQYGPQGGYP	RQPNYNALPN	ANYPSAGMAG	GINPMGAGGQ	MHGQPGIPPY
GTLPPGRMSH	ASMGNRPYGP	NMANMPPQVG	SGMCPPPGGM	NRKTQETAVA
MHVAANSIQN	RPPGYPNMNQ	GGMMGTGPPY	GQGINSMAGM	INPQGPPYSM
GGTMANNSAG	MAASPEMMGL	GDVKLTPATK	MNNKADGTPK	TESKSKKSSS
STTTNEKITK	LYELGGEPER	KMWVDRYLAF	TEEKAMGMTN	LPAVGRKPLD
LYRLYVSVKE	IGGLTQVNKN	KKWRELATNL	NVGTSSSAAS	SLKKQYIQCL
YAFECKIERG	EDPPPDIFAA	ADSKKSQPKI	QPPSPAGSGS	MQGPQTPQST
SSSMAEGGDL	KPPTPASTPH	SQIPPLPGMS	RSNSVGIQDA	FNDGSDSTFQ
KRNSMTPNPG	YQPSMNTSDM	MGRMSYEPNK	DPYGSMRKAP	GSDPFMSSGQ
GPNGGMGDPY	SRAAGPGLGN	VAMGPRQHYP	YGGPYDRVRT	EPGIGPEGNM
STGAPQPNLM	PSNPDSGMYS	PSRYPPQQQQ	QQQQRHDSYG	NQFSTQGTPS
GSPFPSQQTT	MYQQQQQNYK	RPMDGTYGPP	AKRHEGEMYS	VPYSTGQGQP
QQQQLPPAQP	QPASQQQAAQ	PSPQQDVYNQ	YGNAYPATAT	AATERRPAGG
PQNQFPFQFG	RDRVSAPPGT	NAQQNMPPQM	MGGPIQASAE	VAQQGTMWQG
RNDMTYNYAN	RQSTGSAPQG	PAYHGVNRTD	EMLHTDQRAN	HEGSWPSHGT
RQPPYGPSAP	VPPMTRPPPS	NYQPPPSMQN	HIPQVSSPAP	LPRPMENRTS
PSKSPFLHSG	MKMQKAGPPV	PASHIAPAPV	QPPMIRRDIT	FPPGSVEATQ
PVLKQRRRLT	MKDIGTPEAW	RVMMSLKSGL	LAESTWALDT	INILLYDDNS
IMTFNLSQLP	GLLELLVEYF	RRCLIEIFGI	LKEYEVGDPG	QRTLLDPGRF
SKVSSPAPME	GGEEEEELLG	PKLEEEEEEE	VVENDEEIAF	SGKDKPASEN
SEEKLISKFD	KLPVKIVQKN	DPFVVDCSDK	LGRVQEFDSG	LLHWRIGGGD
TTEHIQTHFE	SKTELLPSRP	HAPCPPAPRK	HVTTAEGTPG	TTDQEGPPPD
GPPEKRITAT	MDDMLSTRSS	TLTEDGAKSS	EAIKESSKFP	FGISPAQSHR
NIKILEDEPH	SKDETPLCTL	LDWQDSLAKR	CVCVSNTIRS	LSFVPGNDFE
MSKHPGLLLI	LGKLILLHHK	HPERKQAPLT	YEKEEEQDQG	VSCNKVEWWW
DCLEMLRENT	LVTLANISGQ	LDLSPYPESI	CLPVLDGLLH	WAVCPSAEAQ
DPFSTLGPNA	VLSPQRLVLE	TLSKLSIQDN	NVDLILATPP	FSRLEKLYST
MVRFLSDRKN	PVCREMAVVL	LANLAQGDSL	AARAIAVQKG	SIGNLLGFLE
DSLAATQFQQ	SQASLLHMQN	PPFEPTSVDM	MRRAARALLA	LAKVDENHSE
FTLYESRLLD	ISVSPLMNSL	VSQVICDVLF	LIGQS

Funkcija

ARID1A je član porodice SWI/SNF, čiji članovi imaju aktivnosti helikaza i ATPaza i smatra se da regulišu transkripciju određenih gena mijenjajući hromatinsku strukturu oko tih gena. Kodirani protein je dio velikog ATP-ovisnog kompleksa za remodeliranje hromatina SWI/SNF, koji je potreban za transkripcijsku aktivaciju gena koji su normalno potisnuti hromatinom. Ima najmanje dva konzervirana domena koji bi mogli biti važne za njegovu funkciju. Prvo, ima ARID domen, koji je DNK-vezujući domen koji može specifično vezati AT-bogatu DNK sekvencu za koju se zna da je prepoznata putem SWI/SNF kompleksa na beta-globinskom lokusu. Drugo, C-terminal proteina može stimulirati glukokortikoidni receptorski zavisnu aktivaciju transkripcije. Smatra se da protein kodiran ovim genom daje specifičnost kompleksu SWI/SNF i može regrutirati kompleks do svojih ciljeva kroz interakcije protein-DNK ili protein-protein. Za ovaj gen su pronađene dvije varijante transkripta koje kodiraju različite izoforme.^[7]

Klinički značaj

Ovaj gen je obično mutiran u karcinomima želuca,^[9] ćelijama raka jajnika,^[10] i raka gušterače.^[11] U raku dojke udaljene metastaze dobijaju inaktivacijske mutacije u ARID1A koje se ne vide u primarnom tumoru, a smanjena ekspresija ARID1A daje rezistenciju na različite lijekove kao što su trastuzumab i mTOR-inhibitori. Ovi nalazi daju obrazloženje zašto tumori akumuliraju mutacije ARID1A-e.^[12]^[13]

Istraživanje

Čini se da nedostatak ovog gena/proteina štiti pacove od nekih vrsta oštećenja jetre.^[14]

Interakcije

Pokazalo se da ARID1A ima interakcije sa SMARCB1^[15]^[16] i SMARCA4.^[16]^[17]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117713 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000007880 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Takeuchi T, Furihata M, Heng HH, Sonobe H, Ohtsuki Y (juni 1998). "Chromosomal mapping and expression of the human B120 gene". Gene. 213 (1–2): 189–93. doi:10.1016/S0378-1119(98)00194-2. PMID 9630625.
^ Takeuchi T, Chen BK, Qiu Y, Sonobe H, Ohtsuki Y (decembar 1997). "Molecular cloning and expression of a novel human cDNA containing CAG repeats". Gene. 204 (1–2): 71–7. doi:10.1016/S0378-1119(97)00525-8. PMID 9434167.
^ ^a ^b "Entrez Gene: ARID1A AT rich interactive domain 1A (SWI-like)".
^ "UniProt, O14497" (jezik: engleski). Pristupljeno 21. 11. 2021.
^ Wang K, Kan J, Yuen ST, Shi ST, Chu KM, Law S, et al. (oktobar 2011). "Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer". Nature Genetics. 43 (12): 1219–23. doi:10.1038/ng.982. PMID 22037554. S2CID 8884065.
^ Wiegand KC, Shah SP, Al-Agha OM, Zhao Y, Tse K, Zeng T, et al. (oktobar 2010). "ARID1A mutations in endometriosis-associated ovarian carcinomas". The New England Journal of Medicine. 363 (16): 1532–43. doi:10.1056/NEJMoa1008433. PMC 2976679. PMID 20942669.
^ {{ci te journal | vauthors = Shain AH, Giacomini CP, Matsukuma K, Karikari CA, Bashyam MD, Hidalgo M, Maitra A, Pollack JR | display-authors = 6 | title = Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 109 | issue = 5 | pages = E252-9 | date = januar 2012 | pmid = 22233809 | pmc = 3277150 | doi = 10.1073/pnas.1114817109 | doi-access = free }}
^ Berns K, Sonnenblick A, Gennissen A, Brohée S, Hijmans EM, Evers B, et al. (novembar 2016). "Loss of ARID1A Activates ANXA1, which Serves as a Predictive Biomarker for Trastuzumab Resistance". Clinical Cancer Research. 22 (21): 5238–5248. doi:10.1158/1078-0432.CCR-15-2996. PMID 27172896.
^ Yates LR, Knappskog S, Wedge D, Farmery JH, Gonzalez S, Martincorena I, et al. (august 2017). "Genomic Evolution of Breast Cancer Metastasis and Relapse". Cancer Cell. 32 (2): 169–184.e7. doi:10.1016/j.ccell.2017.07.005. PMC 5559645. PMID 28810143.
^ "Tissue Regeneration Promoted through Gene Suppression". Genetic Engineering & Biotechnology News. mart 2016.
^ Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, et al. (februar 2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". The Journal of Biological Chemistry. 277 (7): 5498–505. doi:10.1074/jbc.M108702200. PMID 11734557.
^ ^a ^b Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, et al. (oktobar 1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". The EMBO Journal. 15 (19): 5370–82. doi:10.1002/j.1460-2075.1996.tb00921.x. PMC 452280. PMID 8895581.
^ Zhao K, Wang W, Rando OJ, Xue Y, Swiderek K, Kuo A, Crabtree GR (novembar 1998). "Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling". Cell. 95 (5): 625–36. doi:10.1016/S0092-8674(00)81633-5. PMID 9845365. S2CID 3184211.

Dopunska literatura

Martens JA, Winston F (april 2003). "Recent advances in understanding chromatin remodeling by Swi/Snf complexes". Current Opinion in Genetics & Development. 13 (2): 136–42. doi:10.1016/S0959-437X(03)00022-4. PMID 12672490.
Maruyama K, Sugano S (januar 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR (septembar 1996). "Diversity and specialization of mammalian SWI/SNF complexes". Genes & Development. 10 (17): 2117–30. doi:10.1101/gad.10.17.2117. PMID 8804307.
Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, et al. (oktobar 1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". The EMBO Journal. 15 (19): 5370–82. doi:10.1002/j.1460-2075.1996.tb00921.x. PMC 452280. PMID 8895581.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (oktobar 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Dallas PB, Cheney IW, Liao DW, Bowrin V, Byam W, Pacchione S, et al. (juni 1998). "p300/CREB binding protein-related protein p270 is a component of mammalian SWI/SNF complexes". Molecular and Cellular Biology. 18 (6): 3596–603. doi:10.1128/MCB.18.6.3596. PMC 108941. PMID 9584200.
Dallas PB, Pacchione S, Wilsker D, Bowrin V, Kobayashi R, Moran E (maj 2000). "The human SWI-SNF complex protein p270 is an ARID family member with non-sequence-specific DNA binding activity". Molecular and Cellular Biology. 20 (9): 3137–46. doi:10.1128/MCB.20.9.3137-3146.2000. PMC 85608. PMID 10757798.
Nie Z, Xue Y, Yang D, Zhou S, Deroo BJ, Archer TK, Wang W (decembar 2000). "A specificity and targeting subunit of a human SWI/SNF family-related chromatin-remodeling complex". Molecular and Cellular Biology. 20 (23): 8879–88. doi:10.1128/MCB.20.23.8879-8888.2000. PMC 86543. PMID 11073988.
Takeuchi T, Nicole S, Misaki A, Furihata M, Iwata J, Sonobe H, Ohtsuki Y (februar 2001). "Expression of SMARCF1, a truncated form of SWI1, in neuroblastoma". The American Journal of Pathology. 158 (2): 663–72. doi:10.1016/S0002-9440(10)64008-4. PMC 1850330. PMID 11159203.
Kozmik Z, Machon O, Králová J, Kreslová J, Paces J, Vlcek C (april 2001). "Characterization of mammalian orthologues of the Drosophila osa gene: cDNA cloning, expression, chromosomal localization, and direct physical interaction with Brahma chromatin-remodeling complex". Genomics. 73 (2): 140–8. doi:10.1006/geno.2001.6477. PMID 11318604.
Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, et al. (februar 2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". The Journal of Biological Chemistry. 277 (7): 5498–505. doi:10.1074/jbc.M108702200. PMID 11734557.
Lemon B, Inouye C, King DS, Tjian R (2002). "Selectivity of chromatin-remodelling cofactors for ligand-activated transcription". Nature. 414 (6866): 924–8. doi:10.1038/414924a. PMID 11780067. S2CID 4391100.
Hurlstone AF, Olave IA, Barker N, van Noort M, Clevers H (maj 2002). "Cloning and characterization of hELD/OSA1, a novel BRG1 interacting protein". The Biochemical Journal. 364 (Pt 1): 255–64. doi:10.1042/bj3640255. PMC 1222568. PMID 11988099.
Inoue H, Furukawa T, Giannakopoulos S, Zhou S, King DS, Tanese N (novembar 2002). "Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors". The Journal of Biological Chemistry. 277 (44): 41674–85. doi:10.1074/jbc.M205961200. PMID 12200431.
Nie Z, Yan Z, Chen EH, Sechi S, Ling C, Zhou S, et al. (april 2003). "Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner". Molecular and Cellular Biology. 23 (8): 2942–52. doi:10.1128/MCB.23.8.2942-2952.2003. PMC 152562. PMID 12665591.
Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, et al. (juni 2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell. 113 (7): 905–17. doi:10.1016/S0092-8674(03)00436-7. PMID 12837248.

Vanjski linkovi

ARID1A protein, human na US National Library of Medicine Medical Subject Headings (MeSH)
Lokacija ljudskog genoma ARID1A i stranica sa detaljima o genu ARID1A u UCSC Genome Browseru.
O14497

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117713 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000007880 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9630625-5] Takeuchi T, Furihata M, Heng HH, Sonobe H, Ohtsuki Y (juni 1998). "Chromosomal mapping and expression of the human B120 gene". Gene. 213 (1–2): 189–93. doi:10.1016/S0378-1119(98)00194-2. PMID 9630625.

[pmid9434167-6] Takeuchi T, Chen BK, Qiu Y, Sonobe H, Ohtsuki Y (decembar 1997). "Molecular cloning and expression of a novel human cDNA containing CAG repeats". Gene. 204 (1–2): 71–7. doi:10.1016/S0378-1119(97)00525-8. PMID 9434167.

[entrez-7] "Entrez Gene: ARID1A AT rich interactive domain 1A (SWI-like)".

[UniProt-8] "UniProt, O14497" (jezik: engleski). Pristupljeno 21. 11. 2021.

[pmid22037554-9] Wang K, Kan J, Yuen ST, Shi ST, Chu KM, Law S, et al. (oktobar 2011). "Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer". Nature Genetics. 43 (12): 1219–23. doi:10.1038/ng.982. PMID 22037554. S2CID 8884065.

[pmid20942669-10] Wiegand KC, Shah SP, Al-Agha OM, Zhao Y, Tse K, Zeng T, et al. (oktobar 2010). "ARID1A mutations in endometriosis-associated ovarian carcinomas". The New England Journal of Medicine. 363 (16): 1532–43. doi:10.1056/NEJMoa1008433. PMC 2976679. PMID 20942669.

[pmid22233809-11] {{ci te journal | vauthors = Shain AH, Giacomini CP, Matsukuma K, Karikari CA, Bashyam MD, Hidalgo M, Maitra A, Pollack JR | display-authors = 6 | title = Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 109 | issue = 5 | pages = E252-9 | date = januar 2012 | pmid = 22233809 | pmc = 3277150 | doi = 10.1073/pnas.1114817109 | doi-access = free }}

[pmid27172896-12] Berns K, Sonnenblick A, Gennissen A, Brohée S, Hijmans EM, Evers B, et al. (novembar 2016). "Loss of ARID1A Activates ANXA1, which Serves as a Predictive Biomarker for Trastuzumab Resistance". Clinical Cancer Research. 22 (21): 5238–5248. doi:10.1158/1078-0432.CCR-15-2996. PMID 27172896.

[13] Yates LR, Knappskog S, Wedge D, Farmery JH, Gonzalez S, Martincorena I, et al. (august 2017). "Genomic Evolution of Breast Cancer Metastasis and Relapse". Cancer Cell. 32 (2): 169–184.e7. doi:10.1016/j.ccell.2017.07.005. PMC 5559645. PMID 28810143.

[14] "Tissue Regeneration Promoted through Gene Suppression". Genetic Engineering & Biotechnology News. mart 2016.

[pmid11734557-15] Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, et al. (februar 2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". The Journal of Biological Chemistry. 277 (7): 5498–505. doi:10.1074/jbc.M108702200. PMID 11734557.

[pmid8895581-16] Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, et al. (oktobar 1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". The EMBO Journal. 15 (19): 5370–82. doi:10.1002/j.1460-2075.1996.tb00921.x. PMC 452280. PMID 8895581.

[pmid9845365-17] Zhao K, Wang W, Rando OJ, Xue Y, Swiderek K, Kuo A, Crabtree GR (novembar 1998). "Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling". Cell. 95 (5): 625–36. doi:10.1016/S0092-8674(00)81633-5. PMID 9845365. S2CID 3184211.

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