SMARCA1

(Preusmjereno sa SWI/SNF)

Vjerovatni globalni transcripcijski aktivator SNF2L1 jest protein koji je kod ljudi kodiran genom SMARCA1.[5][6][7]

SMARCA1
Identifikatori
AliasiSMARCA1
Vanjski ID-jeviOMIM: 300012 MGI: 1935127 HomoloGene: 55711 GeneCards: SMARCA1
Lokacija gena (čovjek)
Hromosom X
Hrom.Hromosom X[1]
Hromosom X
Genomska lokacija za SMARCA1
Genomska lokacija za SMARCA1
BendXq25-q26.1Početak129,446,501 bp[1]
Kraj129,523,500 bp[1]
Lokacija gena (miš)
Hromosom X (miš)
Hrom.Hromosom X (miš)[2]
Hromosom X (miš)
Genomska lokacija za SMARCA1
Genomska lokacija za SMARCA1
BendX|X A4Početak46,898,245 bp[2]
Kraj46,981,851 bp[2]
Obrazac RNK ekspresije




Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija ATP-dependent DNA/DNA annealing activity
DNA binding
nucleotide binding
ATP-dependent activity, acting on DNA
GO:0008026 helicase activity
GO:0102490, GO:0102491, GO:0102489, GO:0102488, GO:0102487, GO:0102486, GO:0102485 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0001948, GO:0016582 protein binding
nucleic acid binding
nucleosome binding
hydrolase activity
ATP binding
transcription factor binding
ATPase activity
GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
Ćelijska komponenta CERF complex
Jedro
Nukleoplazma
intracellular membrane-bounded organelle
NURF complex
Biološki proces chromatin remodeling
GO:0009373 regulation of transcription, DNA-templated
transcription, DNA-templated
GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
brain development
neuron differentiation
GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization
GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)
NM_001282874
NM_001282875
NM_003069
NM_139035
NM_001378261

NM_001378262
NM_001378263
NM_001378264

NM_001290708
NM_053123
NM_001358618
NM_001358619

RefSeq (bjelančevina)
NP_001269803
NP_001269804
NP_003060
NP_001365190
NP_001365191

NP_001365192
NP_001365193

NP_001277637
NP_444353
NP_001345547
NP_001345548

Lokacija (UCSC)Chr X: 129.45 – 129.52 MbChr X: 46.9 – 46.98 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Protein koji je kodiran ovim genom član je porodice proteina SWI/SNF. Članovi ove porodice imaju helikazne i ATPaznu aktivnost i smatra se da reguliraju transkripciju određenih gena mijenjajući strukturu hromatina oko njih. Za ovaj gen pronađene su dvije varijante transkripta koje kodiraju različite izoforme.[7]

Reference uredi

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102038 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031099 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Okabe I, Bailey LC, Attree O, Srinivasan S, Perkel JM, Laurent BC, Carlson M, Nelson DL, Nussbaum RL (Oct 1992). "Cloning of human and bovine homologs of SNF2/SWI2: a global activator of transcription in yeast S. cerevisiae". Nucleic Acids Res. 20 (17): 4649–55. doi:10.1093/nar/20.17.4649. PMC 334196. PMID 1408766.
  6. ^ Barak O, Lazzaro MA, Lane WS, Speicher DW, Picketts DJ, Shiekhattar R (Nov 2003). "Isolation of human NURF: a regulator of Engrailed gene expression". EMBO J. 22 (22): 6089–100. doi:10.1093/emboj/cdg582. PMC 275440. PMID 14609955.
  7. ^ a b "Entrez Gene: SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1".

Dopunska literatura uredi