STT3B

STT3B
Identifikatori
Aliasi	STT3B
Vanjski ID-jevi	OMIM: 608605 MGI: 1915542 HomoloGene: 7387 GeneCards: STT3B
Lokacija gena (čovjek)
Hrom.	Hromosom 3 (čovjek)
Kraj	31,637,616 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	115,139,489 bp
Ontologija gena
Molekularna funkcija	• aktivnost sa transferazom; • oligosaccharyl transferase activity; • dolichyl-diphosphooligosaccharide-protein glycotransferase activity; • glycosyltransferase activity; • vezivanje iona metala; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• integral component of membrane; • oligosaccharyltransferase complex; • Endoplazmatski retikulum; • membrana; • endoplasmic reticulum membrane; • GO:0009327 makromolekulani kompleks; • oligosaccharyltransferase I complex;
Biološki proces	• Posttranslacione modifikacije; • GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation; • co-translational protein modification; • response to unfolded protein; • protein N-linked glycosylation via asparagine; • ubiquitin-dependent ERAD pathway; • glycoprotein catabolic process;
	Izvori:Amigo / QuickGO
Ortolozi
	201595
	68292
	ENSG00000163527
	ENSMUSG00000032437
	Q8TCJ2
	Q3TDQ1
	NM_178862
	NM_024222
	NP_849193
	NP_077184
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Podjedinica STT3B dolihil-difosfooligosaharid-protein glikoziltransferaze jest enzim koji je kod ljudi kodiran genom STT3B sa hromosoma 3.^[5]^[6]^[7]

Aminokiselinska sekvenca

STT3B protein sadrži visoko imunogeni epitop manjeg histokompatibilnog antigena od devet aminokiselina, B6(dom1). Poput ITM1 (MIM 601134), STT3B je homologan sa STT3 kvasca, oligosahariltransferaza neophodna za proliferaciju ćelija.^[7]^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163527 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032437 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kelleher DJ, Karaoglu D, Mandon EC, Gilmore R (juli 2003). "Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties". Molecular Cell. 12 (1): 101–11. doi:10.1016/S1097-2765(03)00243-0. PMID 12887896.
^ McBride K, Baron C, Picard S, Martin S, Boismenu D, Bell A, et al. (novembar 2002). "The model B6(dom1) minor histocompatibility antigen is encoded by a mouse homolog of the yeast STT3 gene". Immunogenetics. 54 (8): 562–9. doi:10.1007/s00251-002-0502-4. PMID 12439619. S2CID 25068432.
^ ^a ^b "Entrez Gene: STT3B STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)".
^ "UniProt, Q8TCJ2" (jezik: engleski). Pristupljeno 5. 11. 2021.
^ McBride K, Baron C, Picard S, Martin S, Boismenu D, Bell A, et al. (novembar 2002). "The model B6(dom1) minor histocompatibility antigen is encoded by a mouse homolog of the yeast STT3 gene". Immunogenetics. Springer Science and Business Media LLC. 54 (8): 562–9. doi:10.1007/s00251-002-0502-4. PMID 12439619. S2CID 25068432.

Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (novembar 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Shibatani T, David LL, McCormack AL, Frueh K, Skach WR (april 2005). "Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits". Biochemistry. 44 (16): 5982–92. doi:10.1021/bi047328f. PMID 15835887.