SRPRB
Podjedinica signalnog prepoznavanja receptorske čestice jest protein koji je kod ljudi kodiran genom SRPRB sa hromosoma 3.[5][6][7]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 271 aminokiselina, a molekulska težina 29.702 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MASADSRRVA | DGGGAGGTFQ | PYLDTLRQEL | QQTDPTLLSV | VVAVLAVLLT | ||||
| LVFWKLIRSR | RSSQRAVLLV | GLCDSGKTLL | FVRLLTGLYR | DTQTSITDSC | ||||
| AVYRVNNNRG | NSLTLIDLPG | HESLRLQFLE | RFKSSARAIV | FVVDSAAFQR | ||||
| EVKDVAEFLY | QVLIDSMGLK | NTPSFLIACN | KQDIAMAKSA | KLIQQQLEKE | ||||
| LNTLRVTRSA | APSTLDSSST | APAQLGKKGK | EFEFSQLPLK | VEFLECSAKG | ||||
| GRGDVGSADI | QDLEKWLAKI | A |
Funkcija
urediProtein kodiran ovim genom sličan je mišjem proteinu koji je podjedinica receptora čestica za prepoznavanje signala (SR). Ova podjedinica je transmembranska GTPaza koja pripada natpotodici GTPaza. Ona sidri alfa podjedinicu, GTPazu periferne membrane, za ER membranu (ER). SR je potreban za kotranslacijsko ciljanje i sekretornih i membranskih proteina na ER membranu.[7]
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000144867 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032553 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Miller JD, Tajima S, Lauffer L, Walter P (Mar 1995). "The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane". J Cell Biol. 128 (3): 273–82. doi:10.1083/jcb.128.3.273. PMC 2120348. PMID 7844142.
- ^ Legate KR, Falcone D, Andrews DW (Oct 2000). "Nucleotide-dependent binding of the GTPase domain of the signal recognition particle receptor beta-subunit to the alpha-subunit". J Biol Chem. 275 (35): 27439–46. doi:10.1074/jbc.M003215200. PMID 10859309.
- ^ a b c "Entrez Gene: SRPRB signal recognition particle receptor, B subunit".
Dopunska literatura
uredi- Bacher G, Pool M, Dobberstein B (1999). "The Ribosome Regulates the Gtpase of the β-Subunit of the Signal Recognition Particle Receptor". J. Cell Biol. 146 (4): 723–30. doi:10.1083/jcb.146.4.723. PMC 2156146. PMID 10459008.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Yan W, Wang WL, Zhu F, et al. (2003). "Isolation of a novel member of small G protein superfamily and its expression in colon cancer". World J. Gastroenterol. 9 (8): 1719–24. doi:10.3748/wjg.v9.i8.1719. PMC 4611530. PMID 12918107.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
- Li Q, Yan W, Cheng S, et al. (2007). "Introduction of G1 phase arrest in Human Hepatocellular carcinoma cells (HHCC) by APMCF1 gene transfection through the down-regulation of TIMP3 and up-regulation of the CDK inhibitors p21". Mol. Biol. Rep. 33 (4): 257–63. doi:10.1007/s11033-006-9007-9. PMID 17080297. S2CID 1871553.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.