MAPK12
(Preusmjereno sa Mitogen-aktivirana protein kinaza)
Mitogen-aktivirana protein-kinaza 12 (MAP-kinaza 12), znana i kao vanćeliskim signalom regulirana kinaza 6 (ERK6) ili stresno aktivirana protein kinaza 3 (SAPK3), jest enzim koji je kod ljudi kodiran genom MAPK12 sa hromosoma 22.[5]
Aminokiselinska sekvenca uredi
Dužina polipeptidnog lanca je 367 aminokiselina, a molekulska težina 41.940 Da.[5]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MSSPPPARSG | FYRQEVTKTA | WEVRAVYRDL | QPVGSGAYGA | VCSAVDGRTG | ||||
| AKVAIKKLYR | PFQSELFAKR | AYRELRLLKH | MRHENVIGLL | DVFTPDETLD | ||||
| DFTDFYLVMP | FMGTDLGKLM | KHEKLGEDRI | QFLVYQMLKG | LRYIHAAGII | ||||
| HRDLKPGNLA | VNEDCELKIL | DFGLARQADS | EMTGYVVTRW | YRAPEVILNW | ||||
| MRYTQTVDIW | SVGCIMAEMI | TGKTLFKGSD | HLDQLKEIMK | VTGTPPAEFV | ||||
| QRLQSDEAKN | YMKGLPELEK | KDFASILTNA | SPLAVNLLEK | MLVLDAEQRV | ||||
| TAGEALAHPY | FESLHDTEDE | PQVQKYDDSF | DDVDRTLDEW | KRVTYKEVLS | ||||
| FKPPRQLGAR | VSKETPL |
Funkcija uredi
Aktivacija članova porodice mitogen-aktiviranih protein kinaza je glavni mehanizam za transdukciju vanćelijskih signala. Proteinske kinaze aktivirane stresom su jedna potklasa MAP-kinaza. Protein kodiran ovim genom funkcionira kao pretvarač signala tokom diferencijacije mioblasta u miotube.[5]
Reference uredi
- ^ a b c GRCh38: Ensembl release 89: ENSG00000188130 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022610 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c "Entrez Gene: mitogen-activated protein kinase 12".
Dopunska literatura uredi
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- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Tosti E, Waldbaum L, Warshaw G, et al. (2004). "The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway". J. Biol. Chem. 279 (46): 47652–60. doi:10.1074/jbc.M409961200. PMID 15342622.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Qi X, Pohl NM, Loesch M, et al. (2007). "p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response". J. Biol. Chem. 282 (43): 31398–408. doi:10.1074/jbc.M703857200. PMID 17724032.
- Collins JE, Wright CL, Edwards CA, et al. (2004). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
- Kukkonen-Macchi A, Sicora O, Kaczynska K, et al. (2011). "Loss of p38gamma MAPK induces pleiotropic mitotic defects and massive cell death". J. Cell Sci. 124 (Pt 2): 216–27. doi:10.1242/jcs.068254. PMID 21172807.
- Sofroniew MV, Howe CL, Mobley WC (2001). "Nerve growth factor signaling, neuroprotection, and neural repair". Annu. Rev. Neurosci. 24: 1217–81. doi:10.1146/annurev.neuro.24.1.1217. PMID 11520933.
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Vanjski linkovi uredi
Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.