MGAT1

MGAT1
Identifikatori
Aliasi	MGAT1
Vanjski ID-jevi	OMIM: 160995 MGI: 96973 HomoloGene: 1804 GeneCards: MGAT1
Lokacija gena (čovjek)
Hrom.	Hromosom 5 (čovjek)
Kraj	180,815,652 bp
Lokacija gena (miš)
Hrom.	Hromosom 11 (miš)
Kraj	49,153,857 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• glycosyltransferase activity; • aktivnost sa transferazom; • acetylglucosaminyltransferase activity; • vezivanje iona metala; • alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity; • manganese ion binding;
Ćelijska komponenta	• integral component of membrane; • extracellular vesicle; • Golđijeva membrana; • Golđijev aparat; • Egzosom; • membrana;
Biološki proces	• GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation; • in utero embryonic development; • UDP-N-acetylglucosamine catabolic process; • carbohydrate metabolic process; • protein N-linked glycosylation; • protein N-linked glycosylation via asparagine;
	Izvori:Amigo / QuickGO
Ortolozi
	4245
	17308
	ENSG00000131446
	ENSMUSG00000020346
	P26572
	P27808
	NM_001114617; NM_001114618; NM_001114619; NM_001114620; NM_002406
	NM_001110148; NM_001110149; NM_001110150; NM_010794
NP_001108089; NP_001108090; NP_001108091; NP_001108092; NP_002397;
	NP_001351306; NP_001351308; NP_001351309; NP_001351310; NP_001351311; NP_001351312; NP_001351313; NP_001351314; NP_001351315; NP_001351316; NP_001351317; NP_001351318; NP_001351319; NP_001351320; NP_001351321; NP_001351322; NP_001351323; NP_001351324
	NP_001103618; NP_001103619; NP_001103620; NP_034924
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Alfa-1,3-manozil-glikoprotein 2-beta-N-acetilglukozaminiltransferaza jest enzim koji je kod ljudi kodiran genom MGAT1 sa hromosoma 5.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 445 aminokiselina, а molekulska težina 50.878 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MLKKQSAGLV	LWGAILFVAW	NALLLLFFWT	RPAPGRPPSV	SALDGDPASL
TREVIRLAQD	AEVELERQRG	LLQQIGDALS	SQRGRVPTAA	PPAQPRVPVT
PAPAVIPILV	IACDRSTVRR	CLDKLLHYRP	SAELFPIIVS	QDCGHEETAQ
AIASYGSAVT	HIRQPDLSSI	AVPPDHRKFQ	GYYKIARHYR	WALGQVFRQF
RFPAAVVVED	DLEVAPDFFE	YFRATYPLLK	ADPSLWCVSA	WNDNGKEQMV
DASRPELLYR	TDFFPGLGWL	LLAELWAELE	PKWPKAFWDD	WMRRPEQRQG
RACIRPEISR	TMTFGRKGVS	HGQFFDQHLK	FIKLNQQFVH	FTQLDLSYLQ
REAYDRDFLA	RVYGAPQLQV	EKVRTNDRKE	LGEVRVQYTG	RDSFKAFAKA
LGVMDDLKSG	VPRAGYRGIV	TFQFRGRRVH	LAPPLTWEGY	DPSWN

Funkcija

Postoji više od 100 različitih glikoziltransferaza uključenih u sintezu i vezanje proteina vezanih i za lipidne oligosaharide. UDP-N-acetilglukozamin: alfa-3-D-manozid beta-1,2-N-acetilglukozaminiltransferaza I je posredujući enzim Golgijevog aparata, bitan za sintezu hibridnih i složenih N-glikana. Protein, kodiran jednim egzonom, pokazuje tipska obilježja transmembranskog proteina tipa II. Vjeruje se da je protein bitan za normalnu embriogenezu.^[6]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000131446 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020346 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hull E, Sarkar M, Spruijt MP, Hoppener JW, Dunn R, Schachter H (Jun 1991). "Organization and localization to chromosome 5 of the human UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I gene". Biochem Biophys Res Commun. 176 (2): 608–15. doi:10.1016/S0006-291X(05)80227-X. PMID 1827260.
^ ^a ^b "Entrez Gene: MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase".
^ "UniProt, P26572" (jezik: engleski). Pristupljeno 17. 10. 2021.

Dopunska literatura

Kumar R, Yang J, Eddy RL, et al. (1992). "Cloning and expression of the murine gene and chromosomal location of the human gene encoding N-acetylglucosaminyltransferase I". Glycobiology. 2 (4): 383–93. doi:10.1093/glycob/2.4.383. PMID 1421759.
Kumar R, Yang J, Larsen RD, Stanley P (1991). "Cloning and expression of N-acetylglucosaminyltransferase I, the medial Golgi transferase that initiates complex N-linked carbohydrate formation". Proc. Natl. Acad. Sci. U.S.A. 87 (24): 9948–52. doi:10.1073/pnas.87.24.9948. PMC 55291. PMID 1702225.
Tan J, D'Agostaro AF, Bendiak B, et al. (1995). "The human UDP-N-acetylglucosamine: alpha-6-D-mannoside-beta-1,2- N-acetylglucosaminyltransferase II gene (MGAT2). Cloning of genomic DNA, localization to chromosome 14q21, expression in insect cells and purification of the recombinant protein". Eur. J. Biochem. 231 (2): 317–28. doi:10.1111/j.1432-1033.1995.tb20703.x. PMID 7635144.
Yip B, Chen SH, Mulder H, et al. (1997). "Organization of the human beta-1,2-N-acetylglucosaminyltransferase I gene (MGAT1), which controls complex and hybrid N-glycan synthesis". Biochem. J. 321 (2): 465–74. doi:10.1042/bj3210465. PMC 1218092. PMID 9020882.
Yen CL, Stone SJ, Cases S, et al. (2002). "Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase". Proc. Natl. Acad. Sci. U.S.A. 99 (13): 8512–7. Bibcode:2002PNAS...99.8512Y. doi:10.1073/pnas.132274899. PMC 124292. PMID 12077311.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Saribas AS, Johnson K, Liu L, et al. (2007). "Refolding of human beta-1-2 GlcNAc transferase (GnT1) and the role of its unpaired Cys 121". Biochem. Biophys. Res. Commun. 362 (2): 381–6. doi:10.1016/j.bbrc.2007.07.199. PMID 17716624.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000131446 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020346 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1827260-5] Hull E, Sarkar M, Spruijt MP, Hoppener JW, Dunn R, Schachter H (Jun 1991). "Organization and localization to chromosome 5 of the human UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I gene". Biochem Biophys Res Commun. 176 (2): 608–15. doi:10.1016/S0006-291X(05)80227-X. PMID 1827260.

[entrez-6] "Entrez Gene: MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase".

[UniProt-7] "UniProt, P26572" (jezik: engleski). Pristupljeno 17. 10. 2021.

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