MAN1A1
Manozil-oligosaharid 1,2-alfa-mannozidaza IA jest enzim koji je kod ljudi kodiran genom MAN1A1.[5][6]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 653 aminokiseline, а molekulska težina 72.969 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MPVGGLLPLF | SSPAGGVLGG | GLGGGGGRKG | SGPAALRLTE | KFVLLLVFSA | ||||
| FITLCFGAIF | FLPDSSKLLS | GVLFHSSPAL | QPAADHKPGP | GARAEDAAEG | ||||
| RARRREEGAP | GDPEAALEDN | LARIRENHER | ALREAKETLQ | KLPEEIQRDI | ||||
| LLEKKKVAQD | QLRDKAPFRG | LPPVDFVPPI | GVESREPADA | AIREKRAKIK | ||||
| EMMKHAWNNY | KGYAWGLNEL | KPISKGGHSS | SLFGNIKGAT | IVDALDTLFI | ||||
| MEMKHEFEEA | KSWVEENLDF | NVNAEISVFE | VNIRFVGGLL | SAYYLSGEEI | ||||
| FRKKAVELGV | KLLPAFHTPS | GIPWALLNMK | SGIGRNWPWA | SGGSSILAEF | ||||
| GTLHLEFMHL | SHLSGNPIFA | EKVMNIRTVL | NKLEKPQGLY | PNYLNPSSGQ | ||||
| WGQHHVSVGG | LGDSFYEYLL | KAWLMSDKTD | LEAKKMYFDA | VQAIETHLIR | ||||
| KSSSGLTYIA | EWKGGLLEHK | MGHLTCFAGG | MFALGADAAP | EGMAQHYLEL | ||||
| GAEIARTCHE | SYNRTFMKLG | PEAFRFDGGV | EAIATRQNEK | YYILRPEVME | ||||
| TYMYMWRLTH | DPKYRKWAWE | AVEALENHCR | VNGGYSGLRD | VYLLHESYDD | ||||
| VQQSFFLAET | LKYLYLIFSD | DDLLPLEHWI | FNSEAHLLPI | LPKDKKEVEI | ||||
| REE |
Funkcija
urediOvaj gen kodira sisarsku Golgijevu 1,2-manozidazu klase I, koja je transmembranski protein tipa II. Ovaj protein katalizira uklanjanje tri različita ostatka manoze iz peptid-vezanih Man (9) -GlcNAc (2) oligosaharida i pripada porodici 47 glikozil hidrolaza.[6]
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000111885 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003746 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Bause E, Bieberich E, Rolfs A, Volker C, Schmidt B (Dec 1993). "Molecular cloning and primary structure of Man9-mannosidase from human kidney". Eur J Biochem. 217 (2): 535–40. doi:10.1111/j.1432-1033.1993.tb18274.x. PMID 8223597.
- ^ a b "Entrez Gene: MAN1A1 mannosidase, alpha, class 1A, member 1".
- ^ "UniProt, P33908" (jezik: engleski). Pristupljeno 8. 10. 2021.
Dopunska literatura
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- Kalyanaraman VS, Rodriguez V, Veronese F, et al. (1990). "Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1". AIDS Res. Hum. Retroviruses. 6 (3): 371–80. doi:10.1089/aid.1990.6.371. PMID 2187500.
- Shimizu H, Tsuchie H, Honma H, et al. (1991). "Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins". Jpn. J. Med. Sci. Biol. 43 (3): 75–87. doi:10.7883/yoken1952.43.75. PMID 2283726.
- Leonard CK, Spellman MW, Riddle L, et al. (1990). "Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells". J. Biol. Chem. 265 (18): 10373–82. doi:10.1016/S0021-9258(18)86956-3. PMID 2355006.
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- Kozarsky K, Penman M, Basiripour L, et al. (1989). "Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein". J. Acquir. Immune Defic. Syndr. 2 (2): 163–9. PMID 2649653.
- Robinson WE, Montefiori DC, Mitchell WM (1988). "Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis". AIDS Res. Hum. Retroviruses. 3 (3): 265–82. doi:10.1089/aid.1987.3.265. PMID 2829950.
- Blough HA, Pauwels R, De Clercq E, et al. (1987). "Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins". Biochem. Biophys. Res. Commun. 141 (1): 33–8. doi:10.1016/S0006-291X(86)80330-8. PMID 3099781.
- Montefiori DC, Robinson WE, Mitchell WM (1988). "Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 85 (23): 9248–52. Bibcode:1988PNAS...85.9248M. doi:10.1073/pnas.85.23.9248. PMC 282716. PMID 3264072.
- Bieberich E, Bause E (1995). "Man9-mannosidase from human kidney is expressed in COS cells as a Golgi-resident type II transmembrane N-glycoprotein". Eur. J. Biochem. 233 (2): 644–9. doi:10.1111/j.1432-1033.1995.644_2.x. PMID 7588811.
- Fenouillet E, Jones I, Powell B, et al. (1993). "Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–60. doi:10.1128/JVI.67.1.150-160.1993. PMC 237347. PMID 8093218.
- Yeh JC, Seals JR, Murphy CI, et al. (1993). "Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system". Biochemistry. 32 (41): 11087–99. doi:10.1021/bi00092a019. PMID 8218172.
- Bolmstedt A, Sjölander S, Hansen JE, et al. (1996). "Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (3): 213–20. doi:10.1097/00042560-199607000-00001. PMID 8673525.
- Hu H, Shioda T, Moriya C, et al. (1996). "Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface". J. Virol. 70 (11): 7462–70. doi:10.1128/JVI.70.11.7462-7470.1996. PMC 190813. PMID 8892864.
- Papandreou MJ, Fenouillet E (1997). "Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation". FEBS Lett. 406 (1–2): 191–5. doi:10.1016/S0014-5793(97)00273-1. PMID 9109416. S2CID 17660.
- Bieberich E, Treml K, Völker C, et al. (1997). "Man9-mannosidase from pig liver is a type-II membrane protein that resides in the endoplasmic reticulum. cDNA cloning and expression of the enzyme in COS 1 cells". Eur. J. Biochem. 246 (3): 681–9. doi:10.1111/j.1432-1033.1997.t01-1-00681.x. PMID 9219526.