HACD2

HACD2
Identifikatori
Aliasi	HACD2
Vanjski ID-jevi	OMIM: 615939 MGI: 1918007 HomoloGene: 23409 GeneCards: HACD2
Lokacija gena (čovjek)
Hrom.	Hromosom 3 (čovjek)
Kraj	123,585,053 bp
Lokacija gena (miš)
Hrom.	Hromosom 16 (miš)
Kraj	34,929,547 bp
Ontologija gena
Molekularna funkcija	• protein tyrosine phosphatase activity; • vezivanje enzima; • 3-hydroxyacyl-CoA dehydratase activity; • GO:0001948, GO:0016582 vezivanje za proteine; • lyase activity; • 3R-hydroxyacyl-CoA dehydratase activity; • 3-hydroxy-behenoyl-CoA dehydratase activity; • 3-hydroxy-lignoceroyl-CoA dehydratase activity; • 3-hydroxy-arachidoyl-CoA dehydratase activity; • very-long-chain 3-hydroxyacyl-CoA dehydratase activity;
Ćelijska komponenta	• integral component of membrane; • endoplasmic reticulum membrane; • Endoplazmatski retikulum; • membrana; • integral component of endoplasmic reticulum membrane;
Biološki proces	• fatty acid elongation; • fatty acid biosynthetic process; • sphingolipid biosynthetic process; • long-chain fatty-acyl-CoA biosynthetic process; • very long-chain fatty acid biosynthetic process; • fatty acid metabolic process; • lipid metabolism; • peptidyl-tyrosine dephosphorylation;
	Izvori:Amigo / QuickGO
Ortolozi
	201562
	70757
	ENSG00000206527
	ENSMUSG00000035376
	Q6Y1H2
	Q9D3B1
	NM_001329783; NM_001329784; NM_001329786; NM_001329787; NM_198402
	NM_023587
	NP_001316712; NP_001316713; NP_001316715; NP_001316716; NP_940684
	NP_076076
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

3-Hidroksiacil-CoA dehidrataza 2 jest protein/enzim koji je kod ljudi kodiran genom HACD2 sa hromosoma 3.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 254 aminokiseline, а molekulska težina 28.368 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAAVAATAAA	KGNGGGGGRA	GAGDASGTRK	KKGPGPLATA	YLVIYNVVMT
AGWLVIAVGL	VRAYLAKGSY	HSLYYSIEKP	LKFFQTGALL	EILHCAIGIV
PSSVVLTSFQ	VMSRVFLIWA	VTHSVKEVQS	EDSVLLFVIA	WTITEIIRYS
FYTFSLLNHL	PYLIKWARYT	LFIVLYPMGV	SGELLTIYAA	LPFVRQAGLY
SISLPNKYNF	SFDYYAFLIL	IMISYIPIFP	QLYFHMIHQR	RKILSHTEEH
KKFE

Funkcija

Protein kodiran ovim genom može katalizirati treći korak (dehidracija) u konverziji dugolančanih masnih kiselina u vrlo dugolančane masne kiseline. Kodirani protein nalazi se na membrani endoplazmatskog retikuluma.

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000206527 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035376 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: 3-hydroxyacyl-CoA dehydratase 2". Pristupljeno 22. 9. 2017.
^ "UniProt, Q6Y1H2" (jezik: engleski). Pristupljeno 8. 11. 2021.

Dopunska literatura

Wang B, Pelletier J, Massaad MJ, Herscovics A, Shore GC (2004). "The yeast split-ubiquitin membrane protein two-hybrid screen identifies BAP31 as a regulator of the turnover of endoplasmic reticulum-associated protein tyrosine phosphatase-like B". Mol. Cell. Biol. 24 (7): 2767–78. doi:10.1128/mcb.24.7.2767-2778.2004. PMC 371098. PMID 15024066.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.

Vanjski linkovi

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000206527 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035376 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: 3-hydroxyacyl-CoA dehydratase 2". Pristupljeno 22. 9. 2017.

[UniProt-6] "UniProt, Q6Y1H2" (jezik: engleski). Pristupljeno 8. 11. 2021.

[5]

[1]

[2]

[3]

[4]

[6]