MAPK12
(Preusmjereno sa ERK6)
Mitogen-aktivirana protein-kinaza 12 (MAP-kinaza 12), znana i kao vanćeliskim signalom regulirana kinaza 6 (ERK6) ili stresno aktivirana protein kinaza 3 (SAPK3), jest enzim koji je kod ljudi kodiran genom MAPK12 sa hromosoma 22.[5]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 367 aminokiselina, a molekulska težina 41.940 Da.[5]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MSSPPPARSG | FYRQEVTKTA | WEVRAVYRDL | QPVGSGAYGA | VCSAVDGRTG | ||||
| AKVAIKKLYR | PFQSELFAKR | AYRELRLLKH | MRHENVIGLL | DVFTPDETLD | ||||
| DFTDFYLVMP | FMGTDLGKLM | KHEKLGEDRI | QFLVYQMLKG | LRYIHAAGII | ||||
| HRDLKPGNLA | VNEDCELKIL | DFGLARQADS | EMTGYVVTRW | YRAPEVILNW | ||||
| MRYTQTVDIW | SVGCIMAEMI | TGKTLFKGSD | HLDQLKEIMK | VTGTPPAEFV | ||||
| QRLQSDEAKN | YMKGLPELEK | KDFASILTNA | SPLAVNLLEK | MLVLDAEQRV | ||||
| TAGEALAHPY | FESLHDTEDE | PQVQKYDDSF | DDVDRTLDEW | KRVTYKEVLS | ||||
| FKPPRQLGAR | VSKETPL |
Funkcija
urediAktivacija članova porodice mitogen-aktiviranih protein kinaza je glavni mehanizam za transdukciju vanćelijskih signala. Proteinske kinaze aktivirane stresom su jedna potklasa MAP-kinaza. Protein kodiran ovim genom funkcionira kao pretvarač signala tokom diferencijacije mioblasta u miotube.[5]
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000188130 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022610 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c "Entrez Gene: mitogen-activated protein kinase 12".
Dopunska literatura
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Vanjski linkovi
uredi
Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.