EDEM2

EDEM2
Identifikatori
Aliasi	EDEM2
Vanjski ID-jevi	OMIM: 610302 MGI: 1915540 HomoloGene: 10075 GeneCards: EDEM2
Lokacija gena (čovjek)
Hrom.	Hromosom 20 (čovjek)
Kraj	35,147,336 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	155,571,395 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• calcium ion binding; • mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; • catalytic activity;
Ćelijska komponenta	• endoplasmic reticulum lumen; • Endoplazmatski retikulum; • membrana; • endoplasmic reticulum quality control compartment;
Biološki proces	• endoplasmic reticulum unfolded protein response; • mannose trimming involved in glycoprotein ERAD pathway; • N-glycan processing; • positive regulation of retrograde protein transport, ER to cytosol; • response to unfolded protein; • ubiquitin-dependent glycoprotein ERAD pathway; • trimming of terminal mannose on B branch; • trimming of terminal mannose on C branch; • trimming of first mannose on A branch; • trimming of second mannose on A branch;
	Izvori:Amigo / QuickGO
Ortolozi
	55741
	108687
	ENSG00000088298
	ENSMUSG00000038312
	Q9BV94
	Q8BJT9
	NM_001145025; NM_018217
	NM_145537
	NP_001138497; NP_060687
	NP_663512
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

ER-degradacijskopojačavajući alfa-manozidazoliki protein jest enzim koji je kod ljudi kodiran genom EDEM2 sa hromosoma 20.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 578 aminokiselina, a molekulska težina 64.753 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MPFRLLIPLG	LLCALLPQHH	GAPGPDGSAP	DPAHYRERVK	AMFYHAYDSY
LENAFPFDEL	RPLTCDGHDT	WGSFSLTLID	ALDTLLILGN	VSEFQRVVEV
LQDSVDFDID	VNASVFETNI	RVVGGLLSAH	LLSKKAGVEV	EAGWPCSGPL
LRMAEEAARK	LLPAFQTPTG	MPYGTVNLLH	GVNPGETPVT	CTAGIGTFIV
EFATLSSLTG	DPVFEDVARV	ALMRLWESRS	DIGLVGNHID	VLTGKWVAQD
AGIGAGVDSY	FEYLVKGAIL	LQDKKLMAMF	LEYNKAIRNY	TRFDDWYLWV
QMYKGTVSMP	VFQSLEAYWP	GLQSLIGDID	NAMRTFLNYY	TVWKQFGGLP
EFYNIPQGYT	VEKREGYPLR	PELIESAMYL	YRATGDPTLL	ELGRDAVESI
EKISKVECGF	ATIKDLRDHK	LDNRMESFFL	AETVKYLYLL	FDPTNFIHNN
GSTFDAVITP	YGECILGAGG	YIFNTEAHPI	DPAALHCCQR	LKEEQWEVED
LMREFYSLKR	SRSKFQKNTV	SSGPWEPPAR	PGTLFSPENH	DQARERKPAK
QKVPLLSCPS	QPFTSKLALL	GQVFLDSS

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000088298 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038312 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mast SW, Diekman K, Karaveg K, Davis A, Sifers RN, Moremen KW (Mar 2005). "Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins". Glycobiology. 15 (4): 421–36. doi:10.1093/glycob/cwi014. PMID 15537790.
^ Olivari S, Galli C, Alanen H, Ruddock L, Molinari M (Jan 2005). "A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation". J Biol Chem. 280 (4): 2424–8. doi:10.1074/jbc.C400534200. PMID 15579471.
^ ^a ^b "Entrez Gene: EDEM2 ER degradation enhancer, mannosidase alpha-like 2".

Dopunska literatura

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000088298 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038312 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15537790-5] Mast SW, Diekman K, Karaveg K, Davis A, Sifers RN, Moremen KW (Mar 2005). "Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins". Glycobiology. 15 (4): 421–36. doi:10.1093/glycob/cwi014. PMID 15537790.

[pmid15579471-6] Olivari S, Galli C, Alanen H, Ruddock L, Molinari M (Jan 2005). "A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation". J Biol Chem. 280 (4): 2424–8. doi:10.1074/jbc.C400534200. PMID 15579471.

[entrez-7] "Entrez Gene: EDEM2 ER degradation enhancer, mannosidase alpha-like 2".

[5]

[6]

[7]

[1]

[2]

[3]

[4]