B-ćelijski limfom/leukemijski protein 10 jest protein koji je kod ljudi kodiran genom BCL10 sa hromosoma 1.[5][6] Poput BCL2, BCL3, BCL5, BCL6, BCL7A – i BCL9, ima klinički značaj kod limfoma.

BCL10
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

2MB9

Identifikatori
AliasiBCL10
Vanjski ID-jeviOMIM: 603517 MGI: 1337994 HomoloGene: 2912 GeneCards: BCL10
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za BCL10
Genomska lokacija za BCL10
Bend1p22.3Početak85,265,776 bp[1]
Kraj85,276,632 bp[1]
Lokacija gena (miš)
Hromosom 3 (miš)
Hrom.Hromosom 3 (miš)[2]
Hromosom 3 (miš)
Genomska lokacija za BCL10
Genomska lokacija za BCL10
Bend3|3 H2Početak145,628,559 bp[2]
Kraj145,640,111 bp[2]
Ontologija gena
Molekularna funkcija GO:0001105 transcription coactivator activity
transcription factor binding
protein kinase B binding
NF-kappaB binding
protease binding
protein self-association
kinase binding
protein C-terminus binding
GO:0001948, GO:0016582 vezivanje za proteine
kinase activator activity
vezivanje enzima
protein kinase binding
ubiquitin protein ligase binding
vezivanje identičnih proteina
CARD domain binding
Ćelijska komponenta citoplazma
citosol
membrana
T cell receptor complex
lipopolysaccharide receptor complex
immunological synapse
perinuklearno područje citoplazme
Lipidni splav
cytoplasmic microtubule
Lizozom
jedro
CBM complex
GO:0009327 makromolekulani kompleks
Biološki proces GO:0097285 apoptoza
T cell apoptotic process
regulation of apoptotic process
adaptive immune response
B cell apoptotic process
regulation of T cell receptor signaling pathway
immune system process
Ćelijska smrt
stimulatory C-type lectin receptor signaling pathway
negative regulation of mature B cell apoptotic process
toll-like receptor signaling pathway
GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
Fc-epsilon receptor signaling pathway
cellular defense response
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
cellular response to mechanical stimulus
neural tube closure
response to fungus
positive regulation of T cell activation
positive regulation of NF-kappaB transcription factor activity
immunoglobulin mediated immune response
protein complex oligomerization
positive regulation of mast cell cytokine production
response to food
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of extrinsic apoptotic signaling pathway
positive regulation of phosphorylation
response to molecule of bacterial origin
I-kappaB kinase/NF-kappaB signaling
positive regulation of protein ubiquitination
T cell receptor signaling pathway
protein homooligomerization
Urođeni imunski sistem
protein ubiquitination
positive regulation of apoptotic process
protein heterooligomerization
lipopolysaccharide-mediated signaling pathway
positive regulation of kinase activity
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_003921
NM_001320715

NM_009740

RefSeq (bjelančevina)

NP_001307644
NP_003912
NP_001307644.1

NP_033870

Lokacija (UCSC)Chr 1: 85.27 – 85.28 MbChr 3: 145.63 – 145.64 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Amiokiselininska sekvenca

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Dužina polipeptidnog lanca je 233 aminokiseline, a molekulska težina 26.252 Da.[7]

1020304050
MEPTAPSLTEEDLTEVKKDALENLRVYLCEKIIAERHFDHLRAKKILSRE
DTEEISCRTSSRKRAGKLLDYLQENPKGLDTLVESIRREKTQNFLIQKIT
DEVLKLRNIKLEHLKGLKCSSCEPFPDGATNNLSRSNSDESNFSEKLRAS
TVMYHPEGESSTTPFFSTNSSLNLPVLEVGRTENTIFSSTTLPRPGDPGA
PPLPPDLQLEEEGTCANSSEMFLPLRSRTVSRQ

Funkcija

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Bcl10 je identifikovan po njegovoj translokaciji u slučaju limfoma limfoidnog tkiva povezanog sa sluznicom (MALT). Protein kodiran ovim genom sadrži domen regrutacije kaspaze (CARD), i pokazalo se da indukuje apoptozu i aktivira NF-κB. Izvještava se da ovaj protein stupa u interakciju s drugim domenom CARD-a i upredene zavojnice, koji sadrži proteine za koje se smatra da funkcionišu kao uzvodni regulatori u NF-κB signalizaciji, uključujući CARD9, C-10, C-11 i C-14. Utvrđeno je da ovaj protein formira kompleks sa parakaspazom MALT1, proteinom koji je kodiran drugim genom za koji se zna da je translociran u MALT limfom. Smatra se da MALT1 i Bcl10 sinergiraju u aktivaciji NF-κB, a deregulacija bilo kojeg od njih može doprinijeti istom patogenetskom procesu koji dovodi do maligniteta.[6] Bcl10 je evolucijski konzerviran od Cnidaria i pokazalo se da je funkcionalno konzerviran sve do zebrica.[8][9] Primjetno, baš kao uzvodno CARD-CC familija, Bcl10 je odsutan u insektima i nematodama, a korelirana filogenetska distribucija Bcl10 i CARD-CC proteina ukazuje na konzervirani kompleks.

Interakcije

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Pokazalo se da je BCL10 u interakciji sa:

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000142867 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028191 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Willis TG, Jadayel DM, Du MQ, Peng H, Perry AR, Abdul-Rauf M, Price H, Karran L, Majekodunmi O, Wlodarska I, Pan L, Crook T, Hamoudi R, Isaacson PG, Dyer MJ (mart 1999). "Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types". Cell. 96 (1): 35–45. doi:10.1016/S0092-8674(00)80957-5. PMID 9989495. S2CID 1613152.
  6. ^ a b "Entrez Gene: BCL10 B-cell CLL/lymphoma 10".
  7. ^ "UniProt, O95999" (jezik: engleski). Pristupljeno 21. 11. 2021.
  8. ^ Mazzone P, Scudiero I, Ferravante A, Paolucci M, D'Andrea LE, Varricchio E, Telesio G, De Maio C, Pizzulo M, Zotti T, Reale C, Vito P, Stilo R (april 2015). "Functional characterization of zebrafish. (Danio rerio) Bcl10". PLOS ONE. 10 (4): e0122365. Bibcode:2015PLoSO..1022365M. doi:10.1371/journal.pone.0122365. PMC 4388727. PMID 25849213.
  9. ^ Staal J, Driege Y, Haegman M, Borghi A, Hulpiau P, Lievens L, et al. (2018). "Ancient Origin of the CARD-Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions". Frontiers in Immunology. 9: 1136. doi:10.3389/fimmu.2018.01136. PMC 5978004. PMID 29881386.
  10. ^ Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J (juni 2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. 276 (24): 21405–9. doi:10.1074/jbc.M102488200. PMID 11259443.
  11. ^ a b Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES (april 2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B". J. Biol. Chem. 276 (15): 11877–82. doi:10.1074/jbc.M010512200. PMID 11278692. S2CID 35815019.
  12. ^ Bertin J, Guo Y, Wang L, Srinivasula SM, Jacobson MD, Poyet JL, Merriam S, Du MQ, Dyer MJ, Robison KE, DiStefano PS, Alnemri ES (Dec 2000). "CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B". J. Biol. Chem. 275 (52): 41082–6. doi:10.1074/jbc.C000726200. PMID 11053425.
  13. ^ Lin Q, Liu Y, Moore DJ, Elizer SK, Veach RA, Hawiger J, Ruley HE (2012). "Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes". J. Immunol. 188 (6): 2493–7. doi:10.4049/jimmunol.1101502. PMC 3294148. PMID 22323537.
  14. ^ Wu CJ, Ashwell JD (februar 2008). "NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation". Proc. Natl. Acad. Sci. U.S.A. 105 (8): 3023–8. Bibcode:2008PNAS..105.3023W. doi:10.1073/pnas.0712313105. PMC 2268578. PMID 18287044.
  15. ^ Uren AG, O'Rourke K, Aravind LA, Pisabarro MT, Seshagiri S, Koonin EV, Dixit VM (oktobar 2000). "Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma". Mol. Cell. 6 (4): 961–7. doi:10.1016/S1097-2765(05)00086-9. PMID 11090634.
  16. ^ Yoneda T, Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M (april 2000). "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein". J. Biol. Chem. 275 (15): 11114–20. doi:10.1074/jbc.275.15.11114. PMID 10753917.

Dopunska literatura

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Vanjski linkovi

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