CARD10

CARD10
Identifikatori
Aliasi	CARD10
Vanjski ID-jevi	OMIM: 607209 MGI: 2146012 HomoloGene: 8728 GeneCards: CARD10
Lokacija gena (čovjek)
Hrom.	Hromosom 22 (čovjek)
Kraj	37,519,542 bp
Lokacija gena (miš)
Hrom.	Hromosom 15 (miš)
Kraj	78,687,242 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• signaling receptor complex adaptor activity; • GO:0001948, GO:0016582 vezivanje za proteine; • CARD domain binding;
Ćelijska komponenta	• citoplazma; • CBM complex;
Biološki proces	• regulation of apoptotic process; • activation of NF-kappaB-inducing kinase activity; • negative regulation of cell migration involved in sprouting angiogenesis; • positive regulation of protein localization to nucleus; • GO:0034622 protein-containing complex assembly;
	Izvori:Amigo / QuickGO
Ortolozi
	29775
	105844
	ENSG00000100065
	ENSMUSG00000033170
	Q9BWT7
	P58660
	NM_014550
	NM_130859
	NP_055365
	NP_570929
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 10 sa domenom aktivatora kaspaza jest protein porodice CARD-CC koji je kod ljudi kodiran genom CARD10 sa hromosoma 22.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.032 aminokiseline, a molekulska težina 115.931 Da.

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MPGRAEAGEA	EEEAGAGSGS	EAEEDALWER	IEGVRHRLAR	ALNPAKLTPY
LRQCRVIDEQ	DEEEVLSTYR	FPCRVNRTGR	LMDILRCRGK	RGYEAFLEAL
EFYYPEHFTL	LTGQEPAQRC	SMILDEEGPE	GLTQFLMTEV	RRLREARKSQ
LQREQQLQAR	GRVLEEERAG	LEQRLRDQQQ	AQERCQRLRE	DWEAGSLELL
RLKDENYMIA	MRLAQLSEEK	NSAVLRSRDL	QLAVDQLKLK	VSRLEEECAL
LRRARGPPPG	AEEKEKEKEK	EKEPDNVDLV	SELRAENQRL	TASLRELQEG
LQQEASRPGA	PGSERILLDI	LEHDWREAQD	SRQELCQKLH	AVQGELQWAE
ELRDQYLQEM	EDLRLKHRTL	QKDCDLYKHR	MATVLAQLEE	IEKERDQAIQ
SRDRIQLQYS	QSLIEKDQYR	KQVRGLEAER	DELLTTLTSL	EGTKALLEVQ
LQRAQGGTCL	KACASSHSLC	SNLSSTWSLS	EFPSPLGGPE	ATGEAAVMGG
PEPHNSEEAT	DSEKEINRLS	ILPFPPSAGS	ILRRQREEDP	APPKRSFSSM
SDITGSVTLK	PWSPGLSSSS	SSDSVWPLGK	PEGLLARGCG	LDFLNRSLAI
RVSGRSPPGG	PEPQDKGPDG	LSFYGDRWSG	AVVRRVLSGP	GSARMEPREQ
RVEAAGLEGA	CLEAEAQQRT	LLWNQGSTLP	SLMDSKACQS	FHEALEAWAK
GPGAEPFYIR	ANLTLPERAD	PHALCVKAQE	ILRLVDSAYK	RRQEWFCTRV
DPLTLRDLDR	GTVPNYQRAQ	QLLEVQEKCL	PSSRHRGPRS	NLKKRALDQL
RLVRPKPVGA	PAGDSPDQLL	LEPCAEPERS	LRPYSLVRPL	LVSALRPVVL
LPECLAPRLI	RNLLDLPSSR	LDFQVCPAES	LSGEELCPSS	APGAPKAQPA
TPGLGSRIRA	IQESVGKKHC	LLELGARGVR	ELVQNEIYPI	VIHVEVTEKN
VREVRGLLGR	PGWRDSELLR	QCRGSEQVLW	GLPCSWVQVP	AHEWGHAEEL
AKVVRGRILQ	EQARLVWVEC	GSSRGCPSSS	EA

Funkcija

Domen regrutacije kaspaze (CARD) je proteinski modul koji se sastoji od šest ili sedam antiparalelnih alfa-heliksa. Učestvuje u signaliziranju apoptoze putem visoko specifične homofilne interakcije protein-protein. CARD induciraju aktivnost jedarnog faktora kapa-B (NF-κB; MIM 164011) preko kompleksa IKK (npr. IKBKB; MIM 603258). CARD9 (MIM 607212), CARD10, CARD11 (MIM 607210) i CARD14 (MIM 607211) komuniciraju sa BCL10 (MIM 603517) i uključeni su u signalne komplekse NF-κB. Osim CARD9, ovi CARD proteini su članovi porodice guanilat-kinaza (MAGUK) povezane s membranom (prema OMIM-u).^[7]

Interakcije

Pokazalo se da CARD10 reaguje sa BCL10.^[8]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100065 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033170 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J (June 2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. 276 (24): 21405–9. doi:10.1074/jbc.M102488200. PMID 11259443.
^ Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J (May 2001). "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation". FEBS Lett. 496 (2–3): 121–7. doi:10.1016/S0014-5793(01)02414-0. PMID 11356195.
^ ^a ^b "Entrez Gene: CARD10 caspase recruitment domain family, member 10".
^ Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J (June 2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. 276 (24): 21405–9. doi:10.1074/jbc.M102488200. PMID 11259443.

Dopunska literatura

Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
McAllister-Lucas LM, Inohara N, Lucas PC, Ruland J, Benito A, Li Q, Chen S, Chen FF, Yamaoka S, Verma IM, Mak TW, Núñez G (2001). "Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappaB induction". J. Biol. Chem. 276 (33): 30589–97. doi:10.1074/jbc.M103824200. PMID 11387339.
Sun L, Deng L, Ea CK, Xia ZP, Chen ZJ (2004). "The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes". Mol. Cell. 14 (3): 289–301. doi:10.1016/S1097-2765(04)00236-9. PMID 15125833.
Stilo R, Liguoro D, Di Jeso B, Formisano S, Consiglio E, Leonardi A, Vito P (2004). "Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator". J. Biol. Chem. 279 (33): 34323–31. doi:10.1074/jbc.M402244200. PMID 15184390.
McAllister-Lucas LM, Ruland J, Siu K, Jin X, Gu S, Kim DS, Kuffa P, Kohrt D, Mak TW, Nuñez G, Lucas PC (2007). "CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells". Proc. Natl. Acad. Sci. U.S.A. 104 (1): 139–44. doi:10.1073/pnas.0601947103. PMC 1766317. PMID 17101977.

Vanjski linkovi

Lokacija ljudskog genoma CARD10 i stranica sa detaljima o genu CARD10 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100065 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033170 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11259443-5] Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J (June 2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. 276 (24): 21405–9. doi:10.1074/jbc.M102488200. PMID 11259443.

[pmid11356195-6] Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J (May 2001). "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation". FEBS Lett. 496 (2–3): 121–7. doi:10.1016/S0014-5793(01)02414-0. PMID 11356195.

[entrez-7] "Entrez Gene: CARD10 caspase recruitment domain family, member 10".

[autogenerated1-8] Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J (June 2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. 276 (24): 21405–9. doi:10.1074/jbc.M102488200. PMID 11259443.

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