CARD10
Protein 10 sa domenom aktivatora kaspaza jest protein porodice CARD-CC koji je kod ljudi kodiran genom CARD10 sa hromosoma 22.[5][6][7]
Aminokiselinska sekvenca uredi
Dužina polipeptidnog lanca je 1.032 aminokiseline, a molekulska težina 115.931 Da.
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MPGRAEAGEA | EEEAGAGSGS | EAEEDALWER | IEGVRHRLAR | ALNPAKLTPY | ||||
| LRQCRVIDEQ | DEEEVLSTYR | FPCRVNRTGR | LMDILRCRGK | RGYEAFLEAL | ||||
| EFYYPEHFTL | LTGQEPAQRC | SMILDEEGPE | GLTQFLMTEV | RRLREARKSQ | ||||
| LQREQQLQAR | GRVLEEERAG | LEQRLRDQQQ | AQERCQRLRE | DWEAGSLELL | ||||
| RLKDENYMIA | MRLAQLSEEK | NSAVLRSRDL | QLAVDQLKLK | VSRLEEECAL | ||||
| LRRARGPPPG | AEEKEKEKEK | EKEPDNVDLV | SELRAENQRL | TASLRELQEG | ||||
| LQQEASRPGA | PGSERILLDI | LEHDWREAQD | SRQELCQKLH | AVQGELQWAE | ||||
| ELRDQYLQEM | EDLRLKHRTL | QKDCDLYKHR | MATVLAQLEE | IEKERDQAIQ | ||||
| SRDRIQLQYS | QSLIEKDQYR | KQVRGLEAER | DELLTTLTSL | EGTKALLEVQ | ||||
| LQRAQGGTCL | KACASSHSLC | SNLSSTWSLS | EFPSPLGGPE | ATGEAAVMGG | ||||
| PEPHNSEEAT | DSEKEINRLS | ILPFPPSAGS | ILRRQREEDP | APPKRSFSSM | ||||
| SDITGSVTLK | PWSPGLSSSS | SSDSVWPLGK | PEGLLARGCG | LDFLNRSLAI | ||||
| RVSGRSPPGG | PEPQDKGPDG | LSFYGDRWSG | AVVRRVLSGP | GSARMEPREQ | ||||
| RVEAAGLEGA | CLEAEAQQRT | LLWNQGSTLP | SLMDSKACQS | FHEALEAWAK | ||||
| GPGAEPFYIR | ANLTLPERAD | PHALCVKAQE | ILRLVDSAYK | RRQEWFCTRV | ||||
| DPLTLRDLDR | GTVPNYQRAQ | QLLEVQEKCL | PSSRHRGPRS | NLKKRALDQL | ||||
| RLVRPKPVGA | PAGDSPDQLL | LEPCAEPERS | LRPYSLVRPL | LVSALRPVVL | ||||
| LPECLAPRLI | RNLLDLPSSR | LDFQVCPAES | LSGEELCPSS | APGAPKAQPA | ||||
| TPGLGSRIRA | IQESVGKKHC | LLELGARGVR | ELVQNEIYPI | VIHVEVTEKN | ||||
| VREVRGLLGR | PGWRDSELLR | QCRGSEQVLW | GLPCSWVQVP | AHEWGHAEEL | ||||
| AKVVRGRILQ | EQARLVWVEC | GSSRGCPSSS | EA |
Funkcija uredi
Domen regrutacije kaspaze (CARD) je proteinski modul koji se sastoji od šest ili sedam antiparalelnih alfa-heliksa. Učestvuje u signaliziranju apoptoze putem visoko specifične homofilne interakcije protein-protein. CARD induciraju aktivnost jedarnog faktora kapa-B (NF-κB; MIM 164011) preko kompleksa IKK (npr. IKBKB; MIM 603258). CARD9 (MIM 607212), CARD10, CARD11 (MIM 607210) i CARD14 (MIM 607211) komuniciraju sa BCL10 (MIM 603517) i uključeni su u signalne komplekse NF-κB. Osim CARD9, ovi CARD proteini su članovi porodice guanilat-kinaza (MAGUK) povezane s membranom (prema OMIM-u).[7]
Interakcije uredi
Reference uredi
- ^ a b c GRCh38: Ensembl release 89: ENSG00000100065 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033170 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J (June 2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. 276 (24): 21405–9. doi:10.1074/jbc.M102488200. PMID 11259443.
- ^ Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J (May 2001). "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation". FEBS Lett. 496 (2–3): 121–7. doi:10.1016/S0014-5793(01)02414-0. PMID 11356195.
- ^ a b "Entrez Gene: CARD10 caspase recruitment domain family, member 10".
- ^ Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J (June 2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. 276 (24): 21405–9. doi:10.1074/jbc.M102488200. PMID 11259443.
Dopunska literatura uredi
- Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
- McAllister-Lucas LM, Inohara N, Lucas PC, Ruland J, Benito A, Li Q, Chen S, Chen FF, Yamaoka S, Verma IM, Mak TW, Núñez G (2001). "Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappaB induction". J. Biol. Chem. 276 (33): 30589–97. doi:10.1074/jbc.M103824200. PMID 11387339.
- Sun L, Deng L, Ea CK, Xia ZP, Chen ZJ (2004). "The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes". Mol. Cell. 14 (3): 289–301. doi:10.1016/S1097-2765(04)00236-9. PMID 15125833.
- Stilo R, Liguoro D, Di Jeso B, Formisano S, Consiglio E, Leonardi A, Vito P (2004). "Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator". J. Biol. Chem. 279 (33): 34323–31. doi:10.1074/jbc.M402244200. PMID 15184390.
- McAllister-Lucas LM, Ruland J, Siu K, Jin X, Gu S, Kim DS, Kuffa P, Kohrt D, Mak TW, Nuñez G, Lucas PC (2007). "CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells". Proc. Natl. Acad. Sci. U.S.A. 104 (1): 139–44. doi:10.1073/pnas.0601947103. PMC 1766317. PMID 17101977.
Vanjski linkovi uredi
- Lokacija ljudskog genoma CARD10 i stranica sa detaljima o genu CARD10 u UCSC Genome Browseru.