ACOX3

ACOX3
Identifikatori
Aliasi	ACOX3
Vanjski ID-jevi	OMIM: 603402 MGI: 1933156 HomoloGene: 37792 GeneCards: ACOX3
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	8,440,723 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	35,772,696 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• oxidoreductase activity, acting on the CH-CH group of donors; • acyl-CoA oxidase activity; • oxidoreductase activity; • signaling receptor binding; • pristanoyl-CoA oxidase activity; • FAD binding; • acyl-CoA dehydrogenase activity; • flavin adenine dinucleotide binding; • fatty acid binding;
Ćelijska komponenta	• membrana; • Peroksisom; • peroxisomal matrix; • mitohondrija; • citosol;
Biološki proces	• lipid metabolism; • fatty acid metabolic process; • fatty acid beta-oxidation using acyl-CoA oxidase; • fatty acid beta-oxidation; • metabolizam; • fatty acid beta-oxidation using acyl-CoA dehydrogenase; • protein targeting to peroxisome; • lipid homeostasis;
	Izvori:Amigo / QuickGO
Ortolozi
	8310
	80911
	ENSG00000087008
	ENSMUSG00000029098
	O15254
	Q9EPL9
	NM_001101667; NM_003501
	NM_030721; NM_001357018; NM_001357019; NM_001357020
NP_001095137; NP_003492; NP_001362712; NP_001362713; NP_001362714;
	NP_001362715; NP_001362716; NP_001362717; NP_001362718; NP_001362719
	NP_109646; NP_001343947; NP_001343948; NP_001343949
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Peroksisomska acil-koenzmska A oksidaza 3 jest enzim koji je kod ljudi kodiran genom ACOX3 sa hromosoma 4.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 700 aminokiselina, а molekulska težina 77.629 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MASTVEGGDT	ALLPEFPRGP	LDAYRARASF	SWKELALFTE	GEGMLRFKKT
IFSALENDPL	FARSPGADLS	LEKYRELNFL	RCKRIFEYDF	LSVEDMFKSP
LKVPALIQCL	GMYDSSLAAK	YLLHSLVFGS	AVYSSGSERH	LTYIQKIFRM
EIFGCFALTE	LSHGSNTKAI	RTTAHYDPAT	EEFIIHSPDF	EAAKFWVGNM
GKTATHAVVF	AKLCVPGDQC	HGLHPFIVQI	RDPKTLLPMP	GVMVGDIGKK
LGQNGLDNGF	AMFHKVRVPR	QSLLNRMGDV	TPEGTYVSPF	KDVRQRFGAS
LGSLSSGRVS	IVSLAILNLK	LAVAIALRFS	ATRRQFGPTE	EEEIPVLEYP
MQQWRLLPYL	AAVYALDHFS	KSLFLDLVEL	QRGLASGDRS	ARQAELGREI
HALASASKPL	ASWTTQQGIQ	ECREACGGHG	YLAMNRLGVL	RDDNDPNCTY
EGDNNILLQQ	TSNYLLGLLA	HQVHDGACFR	SPLKSVDFLD	AYPGILDQKF
EVSSVADCLD	SAVALAAYKW	LVCYLLRETY	QKLNQEKRSG	SSDFEARNKC
QVSHGRPLAL	AFVELTVVQR	FHEHVHQPSV	PPSLRAVLGR	LSALYALWSL
SRHAALLYRG	GYFSGEQAGE	VLESAVLALC	SQLKDDAVAL	VDVIAPPDFV
LDSPIGRADG	ELYKNLWGAV	LQESKVLERA	SWWPEFSVNK	PVIGSLKSKL

Funkcija

Acil-koenzim A oksidaza 3, također poznata kao pristanoil-CoA oksidaza (ACOX3) je uključena u desaturaciju 2-metil razgranatih masnih kiselina u peroksisomima. Za razliku od pacovakog homologa, ljudski gen je eksprimiran u vrlo malim količinama u jetri tako da se njegova iRNK nije mogla otkriti rutinskom Northern blot analizom, imunoblotingom za svoj proizvod ili mjerenjem enzimske aktivnosti. Međutim, ljudska cDNK koje kodira protein od 700 aminokiselina sa peroksisomnim ciljanim C-terminalnim tripeptidom SKL izolirana je i smatra se da se eksprimira pod posebnim uvjetima kao što su specifični razvojne faze ili za tkivo specifičan način u tkivima koja još nisu ispitana.^[6]

Također pogledajte

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000087008 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029098 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vanhooren JC, Marynen P, Mannaerts GP, Van Veldhoven PP (Sep 1997). "Evidence for the existence of a pristanoyl-CoA oxidase gene in man". Biochem J. 325 (3): 593–9. doi:10.1042/bj3250593. PMC 1218600. PMID 9271077.
^ ^a ^b "Entrez Gene: ACOX3 acyl-Coenzyme A oxidase 3, pristanoyl".
^ "UniProt, O15254" (jezik: engleski). Pristupljeno 21. 10. 2021.

Dopunska literatura

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Vanhove GF, Van Veldhoven PP, Fransen M, et al. (1993). "The CoA esters of 2-methyl-branched chain fatty acids and of the bile acid intermediates di- and trihydroxycoprostanic acids are oxidized by one single peroxisomal branched chain acyl-CoA oxidase in human liver and kidney". J. Biol. Chem. 268 (14): 10335–44. doi:10.1016/S0021-9258(18)82206-2. PMID 8387517.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zha S, Ferdinandusse S, Hicks JL, et al. (2005). "Peroxisomal branched chain fatty acid beta-oxidation pathway is upregulated in prostate cancer". Prostate. 63 (4): 316–23. doi:10.1002/pros.20177. PMID 15599942. S2CID 44702394.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

Vanjski linkovi

Lokacija ljudskog genoma ACOX3 i stranica sa detaljima o genu ACOX3 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000087008 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029098 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9271077-5] Vanhooren JC, Marynen P, Mannaerts GP, Van Veldhoven PP (Sep 1997). "Evidence for the existence of a pristanoyl-CoA oxidase gene in man". Biochem J. 325 (3): 593–9. doi:10.1042/bj3250593. PMC 1218600. PMID 9271077.

[entrez-6] "Entrez Gene: ACOX3 acyl-Coenzyme A oxidase 3, pristanoyl".

[UniProt-7] "UniProt, O15254" (jezik: engleski). Pristupljeno 21. 10. 2021.

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