ABL2

ABL2
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2ECD, 2KK1, 2XYN, 3GVU, 3HMI, 3ULR, 4EIH
Identifikatori
Aliasi	ABL2
Vanjski ID-jevi	OMIM: 164690 MGI: 87860 HomoloGene: 5278 GeneCards: ABL2
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	179,229,684 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	156,477,138 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• aktivnost sa transferazom; • protein kinase activity; • nucleotide binding; • actin monomer binding; • manganese ion binding; • non-membrane spanning protein tyrosine kinase activity; • vezivanje iona metala; • kinase activity; • actin filament binding; • GO:0001948, GO:0016582 vezivanje za proteine; • signaling receptor binding; • ATP binding; • magnesium ion binding; • protein tyrosine kinase activity; • phosphotyrosine residue binding;
Ćelijska komponenta	• citoplazma; • citosol; • extrinsic component of cytoplasmic side of plasma membrane; • actin cytoskeleton; • citoskelet;
Biološki proces	• cellular response to retinoic acid; • regulation of actin cytoskeleton reorganization; • Fosforilacija; • positive regulation of phospholipase C activity; • transmembrane receptor protein tyrosine kinase signaling pathway; • positive regulation of cytosolic calcium ion concentration; • GO:1900490 positive regulation of oxidoreductase activity; • regulation of cell motility; • protein phosphorylation; • Ćelijska adhezija; • regulation of cell population proliferation; • positive regulation of neuron projection development; • peptidyl-tyrosine autophosphorylation; • peptidyl-tyrosine phosphorylation; • Urođeni imunski sistem; • GO:0072468 Transdukcija signala; • regulation of autophagy; • regulation of endocytosis; • regulation of cell adhesion; • Ćelijska diferencijacija; • negative regulation of Rho protein signal transduction; • exploration behavior;
	Izvori:Amigo / QuickGO
Ortolozi
	27
	11352
	ENSG00000143322
	ENSMUSG00000026596
	P42684
	Q4JIM5
NM_001136000; NM_001136001; NM_001168236; NM_001168237; NM_001168238;
	NM_001168239; NM_005158; NM_007314
	NM_001136104; NM_009595
NP_001129472; NP_001129473; NP_001161708; NP_001161709; NP_001161710;
	NP_001161711; NP_005149; NP_009298
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Tirozin-protein kinaza ABL2, znana i kao Abelsonovom onkogenu-srodni gen (Arg) jest enzim koji je kod ljudi kodiran genom ABL2 sa hromosoma 1.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.182 aminokiseline, a molekulska težina 128.343 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MGQQVGRVGE	APGLQQPQPR	GIRGSSAARP	SGRRRDPAGR	TTETGFNIFT
QHDHFASCVE	DGFEGDKTGG	SSPEALHRPY	GCDVEPQALN	EAIRWSSKEN
LLGATESDPN	LFVALYDFVA	SGDNTLSITK	GEKLRVLGYN	QNGEWSEVRS
KNGQGWVPSN	YITPVNSLEK	HSWYHGPVSR	SAAEYLLSSL	INGSFLVRES
ESSPGQLSIS	LRYEGRVYHY	RINTTADGKV	YVTAESRFST	LAELVHHHST
VADGLVTTLH	YPAPKCNKPT	VYGVSPIHDK	WEMERTDITM	KHKLGGGQYG
EVYVGVWKKY	SLTVAVKTLK	EDTMEVEEFL	KEAAVMKEIK	HPNLVQLLGV
CTLEPPFYIV	TEYMPYGNLL	DYLRECNREE	VTAVVLLYMA	TQISSAMEYL
EKKNFIHRDL	AARNCLVGEN	HVVKVADFGL	SRLMTGDTYT	AHAGAKFPIK
WTAPESLAYN	TFSIKSDVWA	FGVLLWEIAT	YGMSPYPGID	LSQVYDLLEK
GYRMEQPEGC	PPKVYELMRA	CWKWSPADRP	SFAETHQAFE	TMFHDSSISE
EVAEELGRAA	SSSSVVPYLP	RLPILPSKTR	TLKKQVENKE	NIEGAQDATE
NSASSLAPGF	IRGAQASSGS	PALPRKQRDK	SPSSLLEDAK	ETCFTRDRKG
GFFSSFMKKR	NAPTPPKRSS	SFREMENQPH	KKYELTGNFS	SVASLQHADG
FSFTPAQQEA	NLVPPKCYGG	SFAQRNLCND	DGGGGGGSGT	AGGGWSGITG
FFTPRLIKKT	LGLRAGKPTA	SDDTSKPFPR	SNSTSSMSSG	LPEQDRMAMT
LPRNCQRSKL	QLERTVSTSS	QPEENVDRAN	DMLPKKSEES	AAPSRERPKA
KLLPRGATAL	PLRTPSGDLA	ITEKDPPGVG	VAGVAAAPKG	KEKNGGARLG
MAGVPEDGEQ	PGWPSPAKAA	PVLPTTHNHK	VPVLISPTLK	HTPADVQLIG
TDSQGNKFKL	LSEHQVTSSG	DKDRPRRVKP	KCAPPPPPVM	RLLQHPSICS
DPTEEPTALT	AGQSTSETQE	GGKKAALGAV	PISGKAGRPV	MPPPQVPLPT
SSISPAKMAN	GTAGTKVALR	KTKQAAEKIS	ADKISKEALL	ECADLLSSAL
TEPVPNSQLV	DTGHQLLDYC	SGYVDCIPQT	RNKFAFREAV	SKLELSLQEL
QVSSAAAGVP	GTNPVLNNLL	SCVQEISDVV	QR

Funkcija

ABL2 je citoplazmatska tirozin-kinaza koja je blisko povezana, ali se razlikuje od ABL1. Sličnost proteina uključuje domene tirozin-kinaze i proširuje se na amino-terminal da uključi SH2 i SH3 domene. ABL2 se eksprimira u normalnim i tumorskim ćelijama. Ekspresija ABL2 gena je veća kod KRAS mutantnog karcinoma pluća nemalih ćelija.^[8] ABL2 genski proizvod izražen je kao dvije varijante koje nose različite amino terminale, oba duga približno po 12-kb.^[6]

Interakcije

Pokazalo se da ABL2 ima interakcije sa tri proteina: Abl gen,^[9] Kagtalazom,^[10] i SORBS2.^[11] Protein Abl gena je također poznat kao homolog 1 virusnog onkogena Abelsonove mišje leukemije i protein je koji je kodiran ljudskim ABL1 genom.^[12] Katalaza je uobičajen enzim koji katalizira razgradnju vodik-peroksida do vode i kisik a.^[13] SORBS2 je također poznat kao sorbin i protein 2 koji sadrži domen SH3 i protein je kod ljudi kodiran genom SORBS2.^[6]^[11]^[14]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143322 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026596 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kruh GD, King CR, Kraus MH, Popescu NC, Amsbaugh SC, McBride WO, Aaronson SA (Jan 1987). "A novel human gene closely related to the abl proto-oncogene". Science. 234 (4783): 1545–8. doi:10.1126/science.3787260. PMID 3787260.
^ ^a ^b ^c "Entrez Gene: ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)".
^ "UniProt, P42684" (jezik: en.). Pristupljeno 6. 12. 2021.CS1 održavanje: nepoznati jezik (link)
^ Nagy, Ádám; Pongor, Lőrinc Sándor; Szabó, András; Santarpia, Mariacarmela; Győrffy, Balázs (15. 2. 2017). "KRAS driven expression signature has prognostic power superior to mutation status in non-small cell lung cancer". International Journal of Cancer. 140 (4): 930–937. doi:10.1002/ijc.30509. ISSN 1097-0215. PMC 5299512. PMID 27859136.
^ Cao C, Leng Y, Li C, Kufe D (april 2003). "Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response". J. Biol. Chem. 278 (15): 12961–7. doi:10.1074/jbc.M300058200. PMID 12569093.
^ Cao C, Leng Y, Kufe D (august 2003). "Catalase activity is regulated by c-Abl and Arg in the oxidative stress response". J. Biol. Chem. 278 (32): 29667–75. doi:10.1074/jbc.M301292200. PMID 12777400.
^ ^a ^b Wang B, Golemis EA, Kruh GD (juli 1997). "ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks". J. Biol. Chem. 272 (28): 17542–50. doi:10.1074/jbc.272.28.17542. PMID 9211900.
^ Szczylik C, Skorski T, Nicolaides NC, Manzella L, Malaguarnera L, Venturelli D, Gewirtz AM, Calabretta B (august 1991). "Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides". Science. 253 (5019): 562–5. Bibcode:1991Sci...253..562S. doi:10.1126/science.1857987. PMID 1857987.
^ Chelikani P, Fita I, Loewen PC (januar 2004). "Diversity of structures and properties among catalases". Cell. Mol. Life Sci. 61 (2): 192–208. doi:10.1007/s00018-003-3206-5. hdl:10261/111097. PMID 14745498. S2CID 4411482.
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.

Dopunska literatura

Bradley WD, Koleske AJ (2009). "Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contexts". J Cell Sci. 122 (19): 3441–54. doi:10.1242/jcs.039859. PMC 2746129. PMID 19759284.
Pendergast AM (2003). "The Abl family kinases: mechanisms of regulation and signaling". Adv. Cancer Res. Advances in Cancer Research. 85: 51–100. doi:10.1016/S0065-230X(02)85003-5. ISBN 0120066858. PMID 12374288.
Muller AJ, Pendergast AM, Havlik MH, et al. (1992). "A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction". Mol. Cell. Biol. 12 (11): 5087–93. doi:10.1128/mcb.12.11.5087. PMC 360442. PMID 1383690.
Kruh GD, Perego R, Miki T, Aaronson SA (1990). "The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases". Proc. Natl. Acad. Sci. U.S.A. 87 (15): 5802–6. Bibcode:1990PNAS...87.5802K. doi:10.1073/pnas.87.15.5802. PMC 54416. PMID 2198571.
Kruh GD, King CR, Kraus MH, et al. (1987). "A novel human gene closely related to the abl proto-oncogene". Science. 234 (4783): 1545–8. doi:10.1126/science.3787260. PMID 3787260.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Wang B, Kruh GD (1996). "Subcellular localization of the Arg protein tyrosine kinase". Oncogene. 13 (1): 193–7. PMID 8700546.
Wang B, Mysliwiec T, Feller SM, et al. (1996). "Proline-rich sequences mediate the interaction of the Arg protein tyrosine kinase with Crk". Oncogene. 13 (7): 1379–85. PMID 8875975.
Wang B, Golemis EA, Kruh GD (1997). "ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks". J. Biol. Chem. 272 (28): 17542–50. doi:10.1074/jbc.272.28.17542. PMID 9211900.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Koval AP, Blakesley VA, Roberts CT, et al. (1998). "Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor". Biochem. J. 330 (2): 923–32. doi:10.1042/bj3300923. PMC 1219226. PMID 9480911.
Hashimoto Y, Katayama H, Kiyokawa E, et al. (1998). "Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor". J. Biol. Chem. 273 (27): 17186–91. doi:10.1074/jbc.273.27.17186. PMID 9642287.
Danial NN, Losman JA, Lu T, et al. (1998). "Direct interaction of Jak1 and v-Abl is required for v-Abl-induced activation of STATs and proliferation". Mol. Cell. Biol. 18 (11): 6795–804. doi:10.1128/mcb.18.11.6795. PMC 109263. PMID 9774693.
Cao C, Ren X, Kharbanda S, et al. (2001). "The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress". J. Biol. Chem. 276 (15): 11465–8. doi:10.1074/jbc.C100050200. PMID 11278261.
Yu HH, Zisch AH, Dodelet VC, Pasquale EB (2001). "Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor". Oncogene. 20 (30): 3995–4006. doi:10.1038/sj.onc.1204524. PMID 11494128.
Endo A, Nagashima K, Kurose H, et al. (2002). "Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII". J. Biol. Chem. 277 (26): 23747–54. doi:10.1074/jbc.M111794200. PMID 11956190.
Abassi YA, Vuori K (2002). "Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling". EMBO J. 21 (17): 4571–82. doi:10.1093/emboj/cdf446. PMC 126186. PMID 12198159.
Bianchi C, Muradore I, Corizzato M, et al. (2002). "The expression of the non-receptor tyrosine kinases Arg and c-abl is differently modulated in B lymphoid cells at different stages of differentiation". FEBS Lett. 527 (1–3): 216–222. doi:10.1016/S0014-5793(02)03233-7. PMID 12220663.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Salomon AR, Ficarro SB, Brill LM, et al. (2003). "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 443–8. Bibcode:2003PNAS..100..443S. doi:10.1073/pnas.2436191100. PMC 141014. PMID 12522270.

Vanjski linkovi

Genes, abl na US National Library of Medicine Medical Subject Headings (MeSH)
Abelson Leukemia Virus na US National Library of Medicine Medical Subject Headings (MeSH)
ABL2 Info with links in the Cell Migration Gateway
Lokacija ljudskog genoma ABL2 i stranica sa detaljima o genu ABL2 u UCSC Genome Browseru.

Portal Biologija

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143322 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026596 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3787260-5] Kruh GD, King CR, Kraus MH, Popescu NC, Amsbaugh SC, McBride WO, Aaronson SA (Jan 1987). "A novel human gene closely related to the abl proto-oncogene". Science. 234 (4783): 1545–8. doi:10.1126/science.3787260. PMID 3787260.

[entrez-6] "Entrez Gene: ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)".

[UniProt-7] "UniProt, P42684" (jezik: en.). Pristupljeno 6. 12. 2021.CS1 održavanje: nepoznati jezik (link)

[8] Nagy, Ádám; Pongor, Lőrinc Sándor; Szabó, András; Santarpia, Mariacarmela; Győrffy, Balázs (15. 2. 2017). "KRAS driven expression signature has prognostic power superior to mutation status in non-small cell lung cancer". International Journal of Cancer. 140 (4): 930–937. doi:10.1002/ijc.30509. ISSN 1097-0215. PMC 5299512. PMID 27859136.

[pmid12569093-9] Cao C, Leng Y, Li C, Kufe D (april 2003). "Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response". J. Biol. Chem. 278 (15): 12961–7. doi:10.1074/jbc.M300058200. PMID 12569093.

[pmid12777400-10] Cao C, Leng Y, Kufe D (august 2003). "Catalase activity is regulated by c-Abl and Arg in the oxidative stress response". J. Biol. Chem. 278 (32): 29667–75. doi:10.1074/jbc.M301292200. PMID 12777400.

[pmid9211900-11] Wang B, Golemis EA, Kruh GD (juli 1997). "ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks". J. Biol. Chem. 272 (28): 17542–50. doi:10.1074/jbc.272.28.17542. PMID 9211900.

[pmid1857987-12] Szczylik C, Skorski T, Nicolaides NC, Manzella L, Malaguarnera L, Venturelli D, Gewirtz AM, Calabretta B (august 1991). "Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides". Science. 253 (5019): 562–5. Bibcode:1991Sci...253..562S. doi:10.1126/science.1857987. PMID 1857987.

[pmid14745498-13] Chelikani P, Fita I, Loewen PC (januar 2004). "Diversity of structures and properties among catalases". Cell. Mol. Life Sci. 61 (2): 192–208. doi:10.1007/s00018-003-3206-5. hdl:10261/111097. PMID 14745498. S2CID 4411482.

[pmid9872452-14] Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.

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