TMPRSS11D

TMPRSS11D
Identifikatori
Aliasi	TMPRSS11D
Vanjski ID-jevi	OMIM: 605369 MGI: 2385221 HomoloGene: 74519 GeneCards: TMPRSS11D
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	67,884,002 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	86,521,279 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0070122 peptidase activity; • serine-type peptidase activity; • hydrolase activity; • serine-type endopeptidase activity;
Ćelijska komponenta	• integral component of membrane; • extracellular region; • ćelijska membrana; • integral component of plasma membrane; • Egzosom; • membrana;
Biološki proces	• respiratory gaseous exchange by respiratory system; • Proteoliza;
	Izvori:Amigo / QuickGO
Ortolozi
	9407
	231382
	ENSG00000153802
	ENSMUSG00000061259
	O60235
	Q8VHK8
	NM_004262
	NM_145561
	NP_004253
	NP_663536
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Serin 11D transmembranska proteaza, jest enzim koji je kod ljudi kodiran genom TMPRSS11D sa hromosoma 4.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 418 aminokiselina, а molekulska težina 46.263 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MYRPARVTST	SRFLNPYVVC	FIVVAGVVIL	AVTIALLVYF	LAFDQKSYFY
RSSFQLLNVE	YNSQLNSPAT	QEYRTLSGRI	ESLITKTFKE	SNLRNQFIRA
HVAKLRQDGS	GVRADVVMKF	QFTRNNNGAS	MKSRIESVLR	QMLNNSGNLE
INPSTEITSL	TDQAAANWLI	NECGAGPDLI	TLSEQRILGG	TEAEEGSWPW
QVSLRLNNAH	HCGGSLINNM	WILTAAHCFR	SNSNPRDWIA	TSGISTTFPK
LRMRVRNILI	HNNYKSATHE	NDIALVRLEN	SVTFTKDIHS	VCLPAATQNI
PPGSTAYVTG	WGAQEYAGHT	VPELRQGQVR	IISNDVCNAP	HSYNGAILSG
MLCAGVPQGG	VDACQGDSGG	PLVQEDSRRL	WFIVGIVSWG	DQCGLPDKPG
VYTRVTAYLD	WIRQQTGI

Funkcija

Ovaj gen kodira tripsinu sličnu serin-proteazu koja se oslobađa iz submukozel serozne žlijezde na sluzničnu membranu. To je integralni membranski protein tipa II i ima 29-38% identiteta u sekvenci katalitske regije sa ljudskim hepsinom, enteropeptidazom, akrozinom, i mastocitnom triptazom. Nekatalitska regija ima malo sličnosti s drugim poznatim proteinima. Ovaj protein može imati određenu biološku ulogu u odbrambenom sistemu domaćina na sluzokožama, nezavisno ili u saradnji sa drugim supstancama u sluzokoži disajnih puteva ili bronhijskim sekretima.^[7]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000153802 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061259 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yamaoka K, Masuda K, Ogawa H, Takagi K, Umemoto N, Yasuoka S (Jun 1998). "Cloning and characterization of the cDNA for human airway trypsin-like protease". J Biol Chem. 273 (19): 11895–901. doi:10.1074/jbc.273.19.11895. PMID 9565616.
^ Yasuoka S, Ohnishi T, Kawano S, Tsuchihashi S, Ogawara M, Masuda K, Yamaoka K, Takahashi M, Sano T (Apr 1997). "Purification, characterization, and localization of a novel trypsin-like protease found in the human airway". Am J Respir Cell Mol Biol. 16 (3): 300–8. doi:10.1165/ajrcmb.16.3.9070615. PMID 9070615.
^ ^a ^b "Entrez Gene: TMPRSS11D transmembrane protease, serine 11D".
^ "UniProt, O60235" (jezik: engleski). Pristupljeno 29. 10. 2021.

Dopunska literatura

Takahashi M, Sano T, Yamaoka K, et al. (2001). "Localization of human airway trypsin-like protease in the airway: an immunohistochemical study". Histochem. Cell Biol. 115 (3): 181–7. doi:10.1007/s004180000243. PMID 11326745. S2CID 25025224.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Miki M, Nakamura Y, Takahashi A, et al. (2003). "Effect of human airway trypsin-like protease on intracellular free Ca2+ concentration in human bronchial epithelial cells". J. Med. Invest. 50 (1–2): 95–107. PMID 12630574.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Iwakiri K, Ghazizadeh M, Jin E, et al. (2004). "Human airway trypsin-like protease induces PAR-2-mediated IL-8 release in psoriasis vulgaris". J. Invest. Dermatol. 122 (4): 937–44. doi:10.1111/j.0022-202X.2004.22415.x. PMID 15102084.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Matsushima R, Takahashi A, Nakaya Y, et al. (2006). "Human airway trypsin-like protease stimulates human bronchial fibroblast proliferation in a protease-activated receptor-2-dependent pathway". Am. J. Physiol. Lung Cell Mol. Physiol. 290 (2): L385–95. doi:10.1152/ajplung.00098.2005. PMID 16199437.
Chokki M, Eguchi H, Hamamura I, et al. (2006). "Human airway trypsin-like protease induces amphiregulin release through a mechanism involving protease-activated receptor-2-mediated ERK activation and TNF alpha-converting enzyme activity in airway epithelial cells". FEBS J. 272 (24): 6387–99. doi:10.1111/j.1742-4658.2005.05035.x. PMID 16336275. S2CID 34294232.
Böttcher E, Matrosovich T, Beyerle M, et al. (2006). "Proteolytic Activation of Influenza Viruses by Serine Proteases TMPRSS2 and HAT from Human Airway Epithelium". J. Virol. 80 (19): 9896–8. doi:10.1128/JVI.01118-06. PMC 1617224. PMID 16973594.

Vanjski linkovi

Q8VHK8

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000153802 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000061259 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9565616-5] Yamaoka K, Masuda K, Ogawa H, Takagi K, Umemoto N, Yasuoka S (Jun 1998). "Cloning and characterization of the cDNA for human airway trypsin-like protease". J Biol Chem. 273 (19): 11895–901. doi:10.1074/jbc.273.19.11895. PMID 9565616.

[pmid9070615-6] Yasuoka S, Ohnishi T, Kawano S, Tsuchihashi S, Ogawara M, Masuda K, Yamaoka K, Takahashi M, Sano T (Apr 1997). "Purification, characterization, and localization of a novel trypsin-like protease found in the human airway". Am J Respir Cell Mol Biol. 16 (3): 300–8. doi:10.1165/ajrcmb.16.3.9070615. PMID 9070615.

[entrez-7] "Entrez Gene: TMPRSS11D transmembrane protease, serine 11D".

[UniProt-8] "UniProt, O60235" (jezik: engleski). Pristupljeno 29. 10. 2021.

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