SENP7
Sentrin-specifična proteaza 7 jest enzim koji je kod ljudi kodiran genom SENP7 sa hromosoma 3.[5][6][7]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 1.050 aminokiselina, а molekulska težina 119.658 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MDKRKLGRRP | SSSEIITEGK | RKKSSSDLSE | IRKMLNAKPE | DVHVQSPLSK | ||||
| FRSSERWTLP | LQWERSLRNK | VISLDHKNKK | HIRGCPVTSK | SSPERQLKVM | ||||
| LTNVLWTDLG | RKFRKTLPRN | DANLCDANKV | QSDSLPSTSV | DSLETCQKLE | ||||
| PLRQSLNLSE | RIPRVILTNV | LGTELGRKYI | RTPPVTEGSL | SDTDNLQSEQ | ||||
| LSSSSDGSLE | SYQNLNPHKS | CYLSERGSQR | SKTVDDNSAK | QTAHNKEKRR | ||||
| KDDGISLLIS | DTQPEDLNSG | SRGCDHLEQE | SRNKDVKYSD | SKVELTLISR | ||||
| KTKRRLRNNL | PDSQYCTSLD | KSTEQTKKQE | DDSTISTEFE | KPSENYHQDP | ||||
| KLPEEITTKP | TKSDFTKLSS | LNSQELTLSN | ATKSASAGST | TETVENSNSI | ||||
| DIVGISSLVE | KDENELNTIE | KPILRGHNEG | NQSLISAEPI | VVSSDEEGPV | ||||
| EHKSSEILKL | QSKQDRETTN | ENESTSESAL | LELPLITCES | VQMSSELCPY | ||||
| NPVMENISSI | MPSNEMDLQL | DFIFTSVYIG | KIKGASKGCV | TITKKYIKIP | ||||
| FQVSLNEISL | LVDTTHLKRF | GLWKSKDDNH | SKRSHAILFF | WVSSDYLQEI | ||||
| QTQLEHSVLS | QQSKSSEFIF | LELHNPVSQR | EELKLKDIMT | EISIISGELE | ||||
| LSYPLSWVQA | FPLFQNLSSK | ESSFIHYYCV | STCSFPAGVA | VAEEMKLKSV | ||||
| SQPSNTDAAK | PTYTFLQKQS | SGCYSLSITS | NPDEEWREVR | HTGLVQKLIV | ||||
| YPPPPTKGGL | GVTNEDLECL | EEGEFLNDVI | IDFYLKYLIL | EKASDELVER | ||||
| SHIFSSFFYK | CLTRKENNLT | EDNPNLSMAQ | RRHKRVRTWT | RHINIFNKDY | ||||
| IFVPVNESSH | WYLAVICFPW | LEEAVYEDFP | QTVSQQSQAQ | QSQNDNKTID | ||||
| NDLRTTSTLS | LSAEDSQSTE | SNMSVPKKMC | KRPCILILDS | LKAASVQNTV | ||||
| QNLREYLEVE | WEVKLKTHRQ | FSKTNMVDLC | PKVPKQDNSS | DCGVYLLQYV | ||||
| ESFFKDPIVN | FELPIHLEKW | FPRHVIKTKR | EDIRELILKL | HLQQQKGSSS | ||||
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000138468 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052917 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
- ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- ^ "Entrez Gene: SENP7 SUMO1/sentrin specific peptidase 7".
- ^ "UniProt, Q9BQF6" (jezik: engleski). Pristupljeno 9. 11. 2021.
Dopunska literatura
uredi- Mikolajczyk J, Drag M, Békés M, Cao JT, Ronai Z, Salvesen GS (2007). "Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs". J. Biol. Chem. 282 (36): 26217–24. doi:10.1074/jbc.M702444200. PMID 17591783.
- Drag M, Mikolajczyk J, Krishnakumar IM, Huang Z, Salvesen GS (2008). "Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family". Biochem. J. 409 (2): 461–9. doi:10.1042/BJ20070940. PMID 17916063. S2CID 12234952.
- Gong L, Millas S, Maul GG, Yeh ET (2000). "Differential regulation of sentrinized proteins by a novel sentrin-specific protease". J. Biol. Chem. 275 (5): 3355–9. doi:10.1074/jbc.275.5.3355. PMID 10652325.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.