SELT

SELT
Identifikatori
Aliasi	SELENOT
Vanjski ID-jevi	OMIM: 607912 MGI: 1916477 HomoloGene: 32304 GeneCards: SELENOT
Lokacija gena (čovjek)
Hrom.	Hromosom 3 (čovjek)
Kraj	150,630,436 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	58,500,554 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• selenium binding; • thioredoxin-disulfide reductase activity; • oxidoreductase activity;
Ćelijska komponenta	• Endoplazmatski retikulum; • endoplasmic reticulum membrane; • membrana; • integral component of membrane;
Biološki proces	• selenocysteine incorporation; • positive regulation of cytosolic calcium ion concentration; • positive regulation of growth hormone secretion; • cellular oxidant detoxification; • response to glucose; • pancreas development; • insulin secretion involved in cellular response to glucose stimulus; • glucose homeostasis; • cell redox homeostasis;
	Izvori:Amigo / QuickGO
Ortolozi
	51714
	69227
	ENSG00000198843
	ENSMUSG00000075700
	P62341
	P62342
	NM_016275
	NM_001040396; NM_026997
	NP_057359
	NP_001035486
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Selenoprotein T, znan i kao SELT, jest protein koji je kod ljudi kodiran genom SELT sa hromosoma 3.^[5]^[6]^[7]

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 195 aminokiselina, а molekulska težina 22.324 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MRLLLLLLVA	ASAMVRSEAS	ANLGGVPSKR	LKMQYATGPL	LKFQICVSG
YRRVFEEYMR	VISQRYPDIR	IEGENYLPQP	IYRHIASFLS	VFKLVLIGLI
IVGKDPFAFF	GMQAPSIWQW	GQENKVYACM	MVFFLSNMIE	NQCMSTGAFE
ITLNDVPVWS	KLESGHLPSM	QQLVQILDNE	MKLNVHMDSI	PHHRS

Gen uredi

Selenocistein je kodiran UGA kodonom koji normalno signalizira završetak translacije. 3' UTR gena selenoproteina ima zajedničku strukturu petlje i drškre, sekvencu insercije sek (SECIS), koja je neophodna za prepoznavanje UGA kao Sec kodona, a ne kao stop signala.^[7]

Struktura proteina uredi

Selenoprotein T ima selenocisteinske (Sec) ostatke na aktivnom mjestu.

Također pogledajte uredi

Selenoprotein

References uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198843 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000075700 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kryukov GV, Kryukov VM, Gladyshev VN (novembar 1999). "New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements". J. Biol. Chem. 274 (48): 33888–97. doi:10.1074/jbc.274.48.33888. PMID 10567350.
^ Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN (maj 2003). "Characterization of mammalian selenoproteomes". Science. 300 (5624): 1439–43. Bibcode:2003Sci...300.1439K. doi:10.1126/science.1083516. PMID 12775843. S2CID 10363908.
^ ^a ^b "Entrez Gene: SELT selenoprotein T".
^ "UniProt, P62341" (jezik: engleski). Pristupljeno 9. 11. 2021.

Dopunska literatura uredi

Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198843 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000075700 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10567350-5] Kryukov GV, Kryukov VM, Gladyshev VN (novembar 1999). "New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements". J. Biol. Chem. 274 (48): 33888–97. doi:10.1074/jbc.274.48.33888. PMID 10567350.

[pmid12775843-6] Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN (maj 2003). "Characterization of mammalian selenoproteomes". Science. 300 (5624): 1439–43. Bibcode:2003Sci...300.1439K. doi:10.1126/science.1083516. PMID 12775843. S2CID 10363908.

[entrez-7] "Entrez Gene: SELT selenoprotein T".

[UniProt-8] "UniProt, P62341" (jezik: engleski). Pristupljeno 9. 11. 2021.

[5]

[6]

[7]

[1]

[2]

[3]

[4]

[8]