SCN4B

SCN4B
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4MZ2, 4MZ3
Identifikatori
Aliasi	SCN4B
Vanjski ID-jevi	OMIM: 608256 MGI: 2687406 HomoloGene: 18384 GeneCards: SCN4B
Lokacija gena (čovjek)
Hrom.	Hromosom 11 (čovjek)
Kraj	118,152,888 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	45,065,450 bp
Ontologija gena
Molekularna funkcija	• sodium channel regulator activity; • transmembrane transporter binding; • sodium channel activity; • voltage-gated ion channel activity; • voltage-gated sodium channel activity involved in cardiac muscle cell action potential; • voltage-gated sodium channel activity;
Ćelijska komponenta	• voltage-gated sodium channel complex; • integral component of membrane; • membrana; • Interkalirani disk; • intrinsic component of plasma membrane; • ćelijska membrana;
Biološki proces	• cardiac muscle contraction; • sodium ion transmembrane transport; • sodium ion transport; • regulation of ion transmembrane transport; • cardiac muscle cell action potential involved in contraction; • ion transport; • regulation of sodium ion transmembrane transporter activity; • GO:0061423 positive regulation of sodium ion transport; • AV node cell action potential; • regulation of heart rate by cardiac conduction; • membrane depolarization during cardiac muscle cell action potential; • regulation of ventricular cardiac muscle cell membrane repolarization;
	Izvori:Amigo / QuickGO
Ortolozi
	6330
	399548
	ENSG00000177098
	ENSMUSG00000046480
	Q8IWT1
	Q7M729
	NM_001142348; NM_001142349; NM_174934
	NM_001013390
	NP_001135820; NP_001135821; NP_777594
	NP_001013408
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

β-podjedinica 4 natrijevog kanala, znana i kao SCN4B ili Naβ4, i pomoćna je podjedinica natrijskih kanala koja može promijeniti njihovu kinetiku. To jest protein koji je kod ljudi kodiran genom SCN4B sa hromosoma 11.^[5]^[6] Mutacije u SCN4B povezane su sa sindromom dugog QT intervala.^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 228 aminokiselina, a molekulska masa 24.969 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MPGAGDGGKA	PARWLGTGLL	GLFLLPVTLS	LEVSVGKATD	IYAVNGTEIL
LPCTFSSCFG	FEDLHFRWTY	NSSDAFKILI	EGTVKNEKSD	PKVTLKDDDR
ITLVGSTKEK	MNNISIVLRD	LEFSDTGKYT	CHVKNPKENN	LQHHATIFLQ
VVDRLEEVDN	TVTLIILAVV	GGVIGLLILI	LLIKKLIIFI	LKKTREKKKE
CLVSSSGNDN	TENGLPGSKA	EEKPPSKV

Funkcija

SCN4B might additionally function as a cell adhesion molecule.^[8]^[9]

Također pogledajte

Natrijski kanal

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000177098 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000046480 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lewis, Amanda H.; Raman, Indira M. (2014-11-15). "Resurgent current of voltage-gated Na+ channels". The Journal of Physiology (jezik: engleski). 592 (22): 4825–4838. doi:10.1113/jphysiol.2014.277582. ISSN 1469-7793. PMC 4259529. PMID 25172941.
^ ^a ^b "Entrez Gene: sodium channel".
^ Medeiros-Domingo A, Kaku T, Tester DJ, Iturralde-Torres P, Itty A, Ye B, Valdivia C, Ueda K, Canizales-Quinteros S, Tusié-Luna MT, Makielski JC, Ackerman MJ (July 2007). "SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome". Circulation. 116 (2): 134–42. doi:10.1161/CIRCULATIONAHA.106.659086. PMC 3332546. PMID 17592081.
^ Shimizu, Hideaki (2016). "Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits". Scientific Reports. 6: 26618. Bibcode:2016NatSR...626618S. doi:10.1038/srep26618. PMC 4877568. PMID 27216889.
^ Shimizu, Hideaki (2017). "Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell-cell adhesion". J Biol Chem. 27 (32): 13428–13440. doi:10.1074/jbc.M117.786509. PMC 5555201. PMID 28655765.

Dopunska literatura

Delgado P, GarcÃa-Zueco JC, Rubio-Félix D, Giralt M (1992). "[Idiopathic thrombocytopenic purpura: present knowledge and future expectations]". Sangre. 37 (6): 449–56. PMID 1293796.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Yu FH, Westenbroek RE, Silos-Santiago I, et al. (2003). "Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2". J. Neurosci. 23 (20): 7577–85. doi:10.1523/JNEUROSCI.23-20-07577.2003. PMC 6740763. PMID 12930796.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Webb J, Wu FF, Cannon SC (2009). "Slow inactivation of the NaV1.4 sodium channel in mammalian cells is impeded by co-expression of the beta1 subunit". Pflügers Arch. 457 (6): 1253–63. doi:10.1007/s00424-008-0600-8. PMC 6207185. PMID 18941776.
Shimizu, Hideaki (2016). "Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits". Scientific Reports. 6: 26618. Bibcode:2016NatSR...626618S. doi:10.1038/srep26618. PMC 4877568. PMID 27216889.

Vanjski linkovi

Q8IWT1

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000177098 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000046480 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Lewis, Amanda H.; Raman, Indira M. (2014-11-15). "Resurgent current of voltage-gated Na+ channels". The Journal of Physiology (jezik: engleski). 592 (22): 4825–4838. doi:10.1113/jphysiol.2014.277582. ISSN 1469-7793. PMC 4259529. PMID 25172941.

[entrez-6] "Entrez Gene: sodium channel".

[pmid17592081-7] Medeiros-Domingo A, Kaku T, Tester DJ, Iturralde-Torres P, Itty A, Ye B, Valdivia C, Ueda K, Canizales-Quinteros S, Tusié-Luna MT, Makielski JC, Ackerman MJ (July 2007). "SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome". Circulation. 116 (2): 134–42. doi:10.1161/CIRCULATIONAHA.106.659086. PMC 3332546. PMID 17592081.

[pmid27216889-8] Shimizu, Hideaki (2016). "Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits". Scientific Reports. 6: 26618. Bibcode:2016NatSR...626618S. doi:10.1038/srep26618. PMC 4877568. PMID 27216889.

[pmid28655765-9] Shimizu, Hideaki (2017). "Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell-cell adhesion". J Biol Chem. 27 (32): 13428–13440. doi:10.1074/jbc.M117.786509. PMC 5555201. PMID 28655765.

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