RPL37A

RPL37A
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4UG0, 4V6X, 5AJ0, 3J92, 4UJE, 4UJD, 4D67, 4V5Z, 4UJC, 4D5Y
Identifikatori
Aliasi	RPL37A
Vanjski ID-jevi	OMIM: 613314 MGI: 98068 HomoloGene: 47964 GeneCards: RPL37A
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	216,579,180 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	72,752,972 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• structural constituent of ribosome; • vezivanje iona metala; • GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje sa RNK;
Ćelijska komponenta	• citosol; • ribozom; • focal adhesion; • intracellular anatomical structure; • cytosolic large ribosomal subunit; • Egzosom; • jedro;
Biološki proces	• viral transcription; • SRP-dependent cotranslational protein targeting to membrane; • translational initiation; • Nonsens-posredovano propadanje iRNK; • Biosinteza bjelančevina; • rRNA processing;
	Izvori:Amigo / QuickGO
Ortolozi
	6168
	19981
	ENSG00000197756
	ENSMUSG00000046330
	P61513
	P61514
	NM_000998
	NM_009084
	NP_000989
	NP_033110
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

60S ribosomki protein L37a jest protein koji je kod ljudi kodiran genom sa hromosoma 2.

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je aminokiselina, a molekulska težina Da.

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

Ovo je protein koji je kod ljudi kodiran genom RPL37A'.^[5]^[6]

Eunkcija

Ribozomi, organele koje katalizuju sintezu proteina, sastoje se od male 40S podjedinice i velike 60S podjedinice. Ove podjedinice zajedno se sastoje od čerirein tio SadržWE četirim tipa RNK i otprilike 80 strukturno različitih proteina. Ovaj gen kodira ribosomski protein koji je komponenta 60S podjedinice. Protein pripada porodici ribosomskih proteina L37AE. Nalazi se u citoplazmi. Protein sadrži domen nalik na cinkov prst tipa C4. Kao što je tipSLo za gene koji kodiraju ribosomske proteine, postoji više obrađenih pseudogena ovog gena dispergiranih kroz genom.^[6]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197756 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000046330 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hoof T, Fislage R, Tummler B (Dec 1992). "Primary sequence of the human ribosomal protein L37a". Nucleic Acids Res. 20 (20): 5475. doi:10.1093/nar/20.20.5475. PMC 334360. PMID 1437567.
^ ^a ^b "Entrez Gene: RPL37A ribosomal protein L37a".

Dopumska literatura

Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
Saha DP, Tirumalai PS, Scala LA, Howells RD (1993). "Human ribosomal protein L37a: cloning of the cDNA and analysis of differential gene expression in tissues and cell lines". Gene. 132 (2): 285–9. doi:10.1016/0378-1119(93)90209-L. PMID 8224875.
Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Odintsova TI, Müller EC, Ivanov AV, et al. (2004). "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing". J. Protein Chem. 22 (3): 249–58. doi:10.1023/A:1025068419698. PMID 12962325. S2CID 10710245.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.