RIOX2

RIOX2
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2XDV, 4BU2, 4BXF
Identifikatori
Aliasi	RIOX2
Vanjski ID-jevi	OMIM: 612049 MGI: 1914264 HomoloGene: 12071 GeneCards: RIOX2
Lokacija gena (čovjek)
Hrom.	Hromosom 3 (čovjek)
Kraj	97,972,457 bp
Lokacija gena (miš)
Hrom.	Hromosom 16 (miš)
Kraj	59,312,824 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• oxidoreductase activity; • dioxygenase activity; • vezivanje iona metala; • histone demethylase activity; • vezivanje identičnih proteina; • histone H3-methyl-lysine-4 demethylase activity; • histone H3-methyl-lysine-36 demethylase activity; • GO:0001106 transcription corepressor activity;
Ćelijska komponenta	• Jedarce; • transcription regulator complex; • jedro; • nukleoplazma; • citosol;
Biološki proces	• GO:0009373 regulation of transcription, DNA-templated; • GO:1901227 negative regulation of transcription by RNA polymerase II; • transcription, DNA-templated; • GO:0045996 negative regulation of transcription, DNA-templated; • histone demethylation; • chromatin remodeling; • peptidyl-arginine hydroxylation; • histone H3-K4 demethylation; • ribosome biogenesis; • histone H3-K36 demethylation; • negative regulation of nucleic acid-templated transcription;
	Izvori:Amigo / QuickGO
Ortolozi
	84864
	67014
	ENSG00000170854
	ENSMUSG00000022724
	Q8IUF8
	Q8CD15
	NM_001042533; NM_001261829; NM_032778; NM_153182
	NM_025910
	NP_001035998; NP_001248758; NP_116167; NP_694822
	NP_080186
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Ribosomska oksigenaza 2 jest enzim koji je kod ljudi kodiran genom RIOX2 sa hromosoma 3.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 465 aminokiselina, а molekulska težina 52.800 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MPKKAKPTGS	GKEEGPAPCK	QMKLEAAGGP	SALNFDSPSS	LFESLISPIK
TETFFKEFWE	QKPLLIQRDD	PALATYYGSL	FKLTDLKSLC	SRGMYYGRDV
NVCRCVNGKK	KVLNKDGKAH	FLQLRKDFDQ	KRATIQFHQP	QRFKDELWRI
QEKLECYFGS	LVGSNVYITP	AGSQGLPPHY	DDVEVFILQL	EGEKHWRLYH
PTVPLAREYS	VEAEERIGRP	VHEFMLKPGD	LLYFPRGTIH	QADTPAGLAH
STHVTISTYQ	NNSWGDFLLD	TISGLVFDTA	KEDVELRTGI	PRQLLLQVES
TTVATRRLSG	FLRTLADRLE	GTKELLSSDM	KKDFIMHRLP	PYSAGDGAEL
STPGGKLPRL	DSVVRLQFKD	HIVLTVLPDQ	DQSDEAQEKM	VYIYHSLKNS
RETHMMGNEE	ETEFHGLRFP	LSHLDALKQI	WNSPAISVKD	LKLTTDEEKE
SLVLSLWTEC	LIQVV

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170854 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022724 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tsuneoka M, Koda Y, Soejima M, Teye K, Kimura H (Sep 2002). "A novel myc target gene, mina53, that is involved in cell proliferation". J Biol Chem. 277 (38): 35450–9. doi:10.1074/jbc.M204458200. PMID 12091391.
^ "Entrez Gene: MINA MYC induced nuclear antigen".
^ "UniProt, Q8IUF8" (jezik: engleski). Pristupljeno 9. 11. 2021.

Dopunska literatura

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Teye K, Tsuneoka M, Arima N, et al. (2004). "Increased Expression of a Myc Target Gene Mina53 in Human Colon Cancer". Am. J. Pathol. 164 (1): 205–16. doi:10.1016/S0002-9440(10)63111-2. PMC 1602225. PMID 14695334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Eilbracht J, Reichenzeller M, Hergt M, et al. (2004). "NO66, a Highly Conserved Dual Location Protein in the Nucleolus and in a Special Type of Synchronously Replicating Chromatin". Mol. Biol. Cell. 15 (4): 1816–32. doi:10.1091/mbc.E03-08-0623. PMC 379278. PMID 14742713.
Tsuneoka M, Fujita H, Arima N, et al. (2005). "Mina53 as a potential prognostic factor for esophageal squamous cell carcinoma". Clin. Cancer Res. 10 (21): 7347–56. doi:10.1158/1078-0432.CCR-03-0543. PMID 15534111.
Eilbracht J, Kneissel S, Hofmann A, Schmidt-Zachmann MS (2005). "Protein NO52--a constitutive nucleolar component sharing high sequence homologies to protein NO66". Eur. J. Cell Biol. 84 (2–3): 279–94. doi:10.1016/j.ejcb.2004.12.022. PMID 15819408.
Zhang Y, Lu Y, Yuan BZ, et al. (2005). "The Human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer". Oncogene. 24 (31): 4873–82. doi:10.1038/sj.onc.1208668. PMID 15897898.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Teye K, Arima N, Nakamura Y, et al. (2007). "Expression of Myc target gene mina53 in subtypes of human lymphoma". Oncol. Rep. 18 (4): 841–8. doi:10.3892/or.18.4.841. PMID 17786344.
Ishizaki H, Yano H, Tsuneoka M, et al. (2007). "Overexpression of the myc target gene Mina53 in advanced renal cell carcinoma". Pathol. Int. 57 (10): 672–80. doi:10.1111/j.1440-1827.2007.02156.x. PMID 17803656. S2CID 20991987.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170854 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022724 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12091391-5] Tsuneoka M, Koda Y, Soejima M, Teye K, Kimura H (Sep 2002). "A novel myc target gene, mina53, that is involved in cell proliferation". J Biol Chem. 277 (38): 35450–9. doi:10.1074/jbc.M204458200. PMID 12091391.

[entrez-6] "Entrez Gene: MINA MYC induced nuclear antigen".

[UniProt-7] "UniProt, Q8IUF8" (jezik: engleski). Pristupljeno 9. 11. 2021.

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