PKD2
Policistin-2 jest protein koji je kod ljudi kodiran genom PKD2 sa hromosoma 4.[5][6]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 968 aminokiselina, а molekulska težina 109 691 Da.[7]
10 | 20 | 30 | 40 | 50 | ||||
---|---|---|---|---|---|---|---|---|
MVNSSRVQPQ | QPGDAKRPPA | PRAPDPGRLM | AGCAAVGASL | AAPGGLCEQR | ||||
GLEIEMQRIR | QAAARDPPAG | AAASPSPPLS | SCSRQAWSRD | NPGFEAEEEE | ||||
EEVEGEEGGM | VVEMDVEWRP | GSRRSAASSA | VSSVGARSRG | LGGYHGAGHP | ||||
SGRRRRREDQ | GPPCPSPVGG | GDPLHRHLPL | EGQPPRVAWA | ERLVRGLRGL | ||||
WGTRLMEESS | TNREKYLKSV | LRELVTYLLF | LIVLCILTYG | MMSSNVYYYT | ||||
RMMSQLFLDT | PVSKTEKTNF | KTLSSMEDFW | KFTEGSLLDG | LYWKMQPSNQ | ||||
TEADNRSFIF | YENLLLGVPR | IRQLRVRNGS | CSIPQDLRDE | IKECYDVYSV | ||||
SSEDRAPFGP | RNGTAWIYTS | EKDLNGSSHW | GIIATYSGAG | YYLDLSRTRE | ||||
ETAAQVASLK | KNVWLDRGTR | ATFIDFSVYN | ANINLFCVVR | LLVEFPATGG | ||||
VIPSWQFQPL | KLIRYVTTFD | FFLAACEIIF | CFFIFYYVVE | EILEIRIHKL | ||||
HYFRSFWNCL | DVVIVVLSVV | AIGINIYRTS | NVEVLLQFLE | DQNTFPNFEH | ||||
LAYWQIQFNN | IAAVTVFFVW | IKLFKFINFN | RTMSQLSTTM | SRCAKDLFGF | ||||
AIMFFIIFLA | YAQLAYLVFG | TQVDDFSTFQ | ECIFTQFRII | LGDINFAEIE | ||||
EANRVLGPIY | FTTFVFFMFF | ILLNMFLAII | NDTYSEVKSD | LAQQKAEMEL | ||||
SDLIRKGYHK | ALVKLKLKKN | TVDDISESLR | QGGGKLNFDE | LRQDLKGKGH | ||||
TDAEIEAIFT | KYDQDGDQEL | TEHEHQQMRD | DLEKEREDLD | LDHSSLPRPM | ||||
SSRSFPRSLD | DSEEDDDEDS | GHSSRRRGSI | SSGVSYEEFQ | VLVRRVDRME | ||||
HSIGSIVSKI | DAVIVKLEIM | ERAKLKRREV | LGRLLDGVAE | DERLGRDSEI | ||||
HREQMERLVR | EELERWESDD | AASQISHGLG | TPVGLNGQPR | PRSSRPSSSQ | ||||
STEGMEGAGG | NGSSNVHV |
Funkcija
urediOvaj gen kodira člana porodice proteina policistina, zvanog TRPP2, ranije poznatog kao policistin-2, PC2 ili APKD2. TRPP2 sadrži višestruke transmembranske domene i citoplazmatske – i C-krajeve. Protein može biti integralni membranski protein uključen u interakcije ćelija–ćelija/matriks. TRPP2 može funkcionirati u razvoju morfologiji i funkciji bubrežne cijevi i može modulirati međućelijsku homeostazu kalcija i druge puteve transdukcije signala. Ovaj protein stupa u interakciju sa policistinom 1 (TRPP1), kako bi proizveo kation-permeabilne struje. Otkrioga je Stefan Somlo na Yale University.
Klinički značaj
urediMutacije ovog gena su povezane sa autosomno dominantnom bolešću policistastih bubrega.[6]
Interakcije
urediPokazalo se da policistin 2 ima interakcije sa proteinima:
TRPC1,[8]
PKD1[8][9] i
TNNI3.[10]
Također pogledajte
urediReference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000118762 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034462 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Peters DJ, Spruit L, Saris JJ, Ravine D, Sandkuijl LA, Fossdal R, Boersma J, van Eijk R, Norby S, Constantinou-Deltas CD, et al. (mart 1994). "Chromosome 4 localization of a second gene for autosomal dominant polycystic kidney disease". Nat Genet. 5 (4): 359–62. doi:10.1038/ng1293-359. PMID 8298643. S2CID 5634589.
- ^ a b "Entrez Gene: PKD2 polycystic kidney disease 2 (autosomal dominant)".
- ^ "UniProt, Q13563" (jezik: engleski). Pristupljeno 30. 10. 2021.
- ^ a b Tsiokas, L; Arnould T; Zhu C; Kim E; Walz G; Sukhatme V P (mart 1999). "Specific association of the gene product of PKD2 with the TRPC1 channel". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 96 (7): 3934–9. Bibcode:1999PNAS...96.3934T. doi:10.1073/pnas.96.7.3934. ISSN 0027-8424. PMC 22398. PMID 10097141.
- ^ Tsiokas, L; Kim E; Arnould T; Sukhatme V P; Walz G (juni 1997). "Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 94 (13): 6965–70. Bibcode:1997PNAS...94.6965T. doi:10.1073/pnas.94.13.6965. ISSN 0027-8424. PMC 21268. PMID 9192675.
- ^ Li, Qiang; Shen Patrick Y; Wu Guanqing; Chen Xing-Zhen (Jan 2003). "Polycystin-2 interacts with troponin I, an angiogenesis inhibitor". Biochemistry. United States. 42 (2): 450–7. doi:10.1021/bi0267792. ISSN 0006-2960. PMID 12525172.
Dopundska literatura
uredi- Islam, Md. Shahidul (januar 2011). Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology. 704. Berlin: Springer. str. 700. ISBN 978-94-007-0264-6.
- Torres VE (1998). "New insights into polycystic kidney disease and its treatment". Curr. Opin. Nephrol. Hypertens. 7 (2): 159–69. doi:10.1097/00041552-199803000-00004. PMID 9529618. S2CID 9719193.
- Deltas CC (2001). "Mutations of the human polycystic kidney disease 2 (PKD2) gene". Hum. Mutat. 18 (1): 13–24. doi:10.1002/humu.1145. PMID 11438989. S2CID 11511861.
- Boletta A, Germino GG (2004). "Role of polycystins in renal tubulogenesis". Trends Cell Biol. 13 (9): 484–92. doi:10.1016/S0962-8924(03)00169-7. PMID 12946628.
- Cantiello HF (2004). "Regulation of calcium signaling by polycystin-2". Am. J. Physiol. Renal Physiol. 286 (6): F1012–29. doi:10.1152/ajprenal.00181.2003. PMID 15130895.
- Everson GT, Taylor MR, Doctor RB (2004). "Polycystic disease of the liver". Hepatology. 40 (4): 774–82. doi:10.1002/hep.20431. PMID 15382167.
- Witzgall R (2007). "TRPP2 channel regulation". Handb Exp Pharmacol. Handbook of Experimental Pharmacology. 179 (179): 363–75. doi:10.1007/978-3-540-34891-7_22. ISBN 978-3-540-34889-4. PMID 17217069.
- Köttgen M (2007). "TRPP2 and autosomal dominant polycystic kidney disease" (PDF). Biochim. Biophys. Acta. 1772 (8): 836–50. doi:10.1016/j.bbadis.2007.01.003. PMID 17292589.
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Mochizuki T, Wu G, Hayashi T, et al. (1996). "PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein". Science. 272 (5266): 1339–42. Bibcode:1996Sci...272.1339M. doi:10.1126/science.272.5266.1339. PMID 8650545. S2CID 28192819.
- Schneider MC, Rodriguez AM, Nomura H, et al. (1997). "A gene similar to PKD1 maps to chromosome 4q22: a candidate gene for PKD2". Genomics. 38 (1): 1–4. doi:10.1006/geno.1996.0584. PMID 8954772.
- Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Qian F, Germino FJ, Cai Y, et al. (1997). "PKD1 interacts with PKD2 through a probable coiled-coil domain". Nat. Genet. 16 (2): 179–83. doi:10.1038/ng0697-179. PMID 9171830. S2CID 32450405.
- Xenophontos S, Constantinides R, Hayashi T, et al. (1997). "A translation frameshift mutation induced by a cytosine insertion in the polycystic kidney disease 2 gene (PDK2)". Hum. Mol. Genet. 6 (6): 949–52. doi:10.1093/hmg/6.6.949. PMID 9175744.
- Tsiokas L, Kim E, Arnould T, et al. (1997). "Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6965–70. Bibcode:1997PNAS...94.6965T. doi:10.1073/pnas.94.13.6965. PMC 21268. PMID 9192675.
- Hayashi T, Mochizuki T, Reynolds DM, et al. (1997). "Characterization of the exon structure of the polycystic kidney disease 2 gene (PKD2)". Genomics. 44 (1): 131–6. doi:10.1006/geno.1997.4851. PMID 9286709.
- Veldhuisen B, Saris JJ, de Haij S, et al. (1997). "A spectrum of mutations in the second gene for autosomal dominant polycystic kidney disease (PKD2)". Am. J. Hum. Genet. 61 (3): 547–55. doi:10.1086/515497. PMC 1715954. PMID 9326320.
- Viribay M, Hayashi T, Tellería D, et al. (1998). "Novel stop and frameshifting mutations in the autosomal dominant polycystic kidney disease 2 (PKD2) gene". Hum. Genet. 101 (2): 229–34. doi:10.1007/s004390050621. PMID 9402976. S2CID 22047464.
- Pei Y, Wang K, Kasenda M, et al. (1998). "A novel frameshift mutation induced by an adenosine insertion in the polycystic kidney disease 2 (PKD2) gene". Kidney Int. 53 (5): 1127–32. doi:10.1046/j.1523-1755.1998.00890.x. PMID 9573526.
Vanjski linkovi
uredi- GeneReviews/NIH/NCBI/UW entry on Polycystic Kidney Disease, Autosomal Dominant
- "Transient Receptor Potential Channels: TRPP1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano s originala, 4. 11. 2021. Pristupljeno 30. 10. 2021.
Šablon:Trepljasti proteini Šablon:Modulatori tranzitnih receptora potencijalnih kanala