PMFBP1

PMFBP1
Identifikatori
Aliasi	PMFBP1
Vanjski ID-jevi	OMIM: 618085 MGI: 1930136 HomoloGene: 23182 GeneCards: PMFBP1
Lokacija gena (čovjek)
Hrom.	Hromosom 16 (čovjek)
Kraj	72,176,878 bp
Lokacija gena (miš)
Hrom.	Hromosom 8 (miš)
Kraj	110,269,272 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• molekularna funkcija;
Ćelijska komponenta	• citoplazma; • Treplja; • motile cilium; • projekcija ćelije; • sperm connecting piece;
Biološki proces	• GO:0022610 biološki proces; • Spermatogeneza;
	Izvori:Amigo / QuickGO
Ortolozi
	83449
	56523
	ENSG00000118557
	ENSMUSG00000031727
	Q8TBY8
	Q9WVQ0
	NM_001160213; NM_031293
	NM_019938
	NP_001153685; NP_112583
	NP_064322
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Poliaminski modulirani faktor 1-vezanja proteina 1 je protein koji je kod ljudi kodiran genom PMFBP1.^[5]^[6]

Gross (2018) mapirao je gen PMFBP1 na hromosomu 16, regija q22.2, na osnovu poravnanja sekvence PMFBP1 (GenBank BC028423) sa genomskom sekvencom (GRCh38).^[7] Ohuchi et al. (2001) izvijestili su da se mišji Pmfbp1 gen nalazi na hromosomu 8.^[8]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.022 aminokiseline, a molekulska težina 119.033 Da^[9].

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin

R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MKDEAGERDR	EVSSLNSKLL	SLQLDIKNLH	DVCKRQRKTL	QDNQLCMEEA
MNSSHDKKQA	QALAFEESEV	EFGSSKQCHL	RQLQQLKKKL	LVLQQELEFH
TEELQTSYYS	LRQYQSILEK	QTSDLVLLHH	HCKLKEDEVI	LYEEEMGNHN
ENTGEKLHLA	QEQLALAGDK	IASLERSLNL	YRDKYQSSLS	NIELLECQVK
MLQGELGGIM	GQEPENKGDH	SKVRIYTSPC	MIQEHQETQK	RLSEVWQKVS
QQDDLIQELR	NKLACSNALV	LEREKALIKL	QADFASCTAT	HRYPPSSSEE
CEDIKKILKH	LQEQKDSQCL	HVEEYQNLVK	DLRVELEAVS	EQKRNIMKDM
MKLELDLHGL	REETSAHIER	KDKDITILQC	RLQELQLEFT	ETQKLTLKKD
KFLQEKDEML	QELEKKLTQV	QNSLLKKEKE	LEKQQCMATE	LEMTVKEAKQ
DKSKEAECKA	LQAEVQKLKN	SLEEAKQQER	LAGEAPAAQQ	AAQCKEEAAL
AGCHLEDTQR	KLQKGLLLDK	QKADTIQELQ	RELQMLQKES	SMAEKEQTSN
RKRVEELSLE	LSEALRKLEN	SDKEKRQLQK	TVAEQDMKMN	DMLDRIKHQH
REQGSIKCKL	EEDLQEATKL	LEDKREQLKK	SKEHEKLMEG	ELEALRQEFK
KKDKTLKENS	RKLEEENENL	RAELQCCSTQ	LESSLNKYNT	SQQVIQDLNK
EIALQKESLM	SLQAQLDKAL	QKEKHYLQTT	ITKEAYDALS	RKSAACQDDL
TQALEKLNHV	TSETKSLQQS	LTQTQEKKAQ	LEEEIIAYEE	RMKKLNTELR
KLRGFHQESE	LEVHAFDKKL	EEMSCQVLQW	QKQHQNDLKM	LAAKEEQLRE
FQEEMAALKE	NLLEDDKEPC	CLPQWSVPKD	TCRLYRGNDQ	IMTNLEQWAK
QQKVANEKLG	NQLREQVKYI	AKLSGEKDHL	HSVMVHLQQE	NKKLKKEIEE
KKMKAENTRL	CTKALGPSRT	ESTQREKVCG	TLGWKGLPQD	MGQRMDLTKY
IGMPHCPGTS	AIGQKNKCDF	FL

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000118557 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031727 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ohuchi J, Arai T, Kon Y, Asano A, Yamauchi H, Watanabe T (Jul 2001). "Characterization of a novel gene, sperm-tail-associated protein (Stap), in mouse post-meiotic testicular germ cells". Mol Reprod Dev. 59 (4): 350–8. doi:10.1002/mrd.1041. PMID 11468771. S2CID 23623069.
^ "Entrez Gene: PMFBP1 polyamine modulated factor 1 binding protein 1".
^ Gross, M. B. Personal Communication. Baltimore, Md. 8/10/2018.
^ Ohuchi, J., Arai, T., Kon, Y., Asano, A., Yamauchi, H., Watanabe, T. Characterization of a novel gene, sperm-tail-associated protein (Stap), in mouse post-meiotic testicular germ cells. Molec. Reprod. Dev. 59: 350-358, 2001. PubMed: 11468771
^ "UniProt, Q8TBY8". Pristupljeno 8. 7. 2021.

Dopunska literatura

Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000118557 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031727 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11468771-5] Ohuchi J, Arai T, Kon Y, Asano A, Yamauchi H, Watanabe T (Jul 2001). "Characterization of a novel gene, sperm-tail-associated protein (Stap), in mouse post-meiotic testicular germ cells". Mol Reprod Dev. 59 (4): 350–8. doi:10.1002/mrd.1041. PMID 11468771. S2CID 23623069.

[entrez-6] "Entrez Gene: PMFBP1 polyamine modulated factor 1 binding protein 1".

[7] Gross, M. B. Personal Communication. Baltimore, Md. 8/10/2018.

[8] Ohuchi, J., Arai, T., Kon, Y., Asano, A., Yamauchi, H., Watanabe, T. Characterization of a novel gene, sperm-tail-associated protein (Stap), in mouse post-meiotic testicular germ cells. Molec. Reprod. Dev. 59: 350-358, 2001. PubMed: 11468771

[UniProt-9] "UniProt, Q8TBY8". Pristupljeno 8. 7. 2021.

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