ADIPOR1

ADIPOR1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	3WXV
Identifikatori
Aliasi	ADIPOR1
Vanjski ID-jevi	OMIM: 607945 MGI: 1919924 HomoloGene: 69199 GeneCards: ADIPOR1
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	202,958,572 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	134,361,089 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• adipokinetic hormone receptor activity; • adiponectin binding; • vezivanje iona metala; • vezivanje identičnih proteina; • protein heterodimerization activity; • protein kinase binding; • signaling receptor activity;
Ćelijska komponenta	• integral component of membrane; • membrana; • intrinsic component of plasma membrane; • ćelijska membrana;
Biološki proces	• glucose homeostasis; • lipid metabolism; • leptin-mediated signaling pathway; • adiponectin-activated signaling pathway; • fatty acid metabolic process; • regulation of lipid metabolic process; • regulation of glucose metabolic process; • negative regulation of cell growth; • fatty acid oxidation; • hormone-mediated signaling pathway; • GO:1903106 positive regulation of insulin receptor signaling pathway; • positive regulation of receptor signaling pathway via JAK-STAT; • negative regulation of epithelial to mesenchymal transition; • negative regulation of receptor signaling pathway via JAK-STAT; • negative regulation of epithelial cell migration; • negative regulation of NIK/NF-kappaB signaling; • G protein-coupled receptor signaling pathway; • regulation of fatty acid biosynthetic process; • positive regulation of cold-induced thermogenesis;
	Izvori:Amigo / QuickGO
Ortolozi
	51094
	72674
	ENSG00000159346
	ENSMUSG00000026457
	Q96A54
	Q91VH1
	NM_001290553; NM_001290557; NM_001290629; NM_015999
	NM_028320; NM_001306069
	NP_001277482; NP_001277486; NP_001277558; NP_057083
	NP_001292998; NP_082596
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Adiponektinski receptor 1 (AdipoR1) jest protein koji je kod ljudi kodiran genom ADIPOR1 sa hromosoma 1.^[5] Član je porodice progestini i adipoQ receptori (PAQR), a poznat je i kao PAQR1.^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 375 aminokiselina, a molekulska težina 42.616 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSSHKGSVVA	QGNGAPASNR	EADTVELAEL	GPLLEEKGKR	VIANPPKAEE
EQTCPVPQEE	EEEVRVLTLP	LQAHHAMEKM	EEFVYKVWEG	RWRVIPYDVL
PDWLKDNDYL	LHGHRPPMPS	FRACFKSIFR	IHTETGNIWT	HLLGFVLFLF
LGILTMLRPN	MYFMAPLQEK	VVFGMFFLGA	VLCLSFSWLF	HTVYCHSEKV
SRTFSKLDYS	GIALLIMGSF	VPWLYYSFYC	SPQPRLIYLS	IVCVLGISAI
IVAQWDRFAT	PKHRQTRAGV	FLGLGLSGVV	PTMHFTIAEG	FVKATTVGQM
GWFFLMAVMY	ITGAGLYAAR	IPERFFPGKF	DIWFQSHQIF	HVLVVAAAFV
HFYGVSNLQE	FRYGLEGGCT	DDTLL

Struktura

Slično G-protein spregnutim receptorima (GPCR), AdipoR1 također ima sedam transmembranskih domena. Međutim, AdipoR1 je orijentiran suprotno od GPCR u membrani (tj., citoplazmatski N-terminal, vanćelijski C-terminal) i ne povezuje se sa G-proteinima.^[5]

Funkcija

Adiponektinski receptori, AdipoR1 i AdipoR2, služe kao receptori za globulasti i punodužinski adiponektin i posreduju u povećanju razine AMP-aktivirane protein-kinaze (AMPK) i PPAR-α aktivnosti liganda, kao i oksidaciji masnih kiselima i uzimanju glukoze za adiponektin.^[5]^[8] Univerzitet u Tokiju je 2016. objavio da pokreće istragu o anonimnim tvrdnjama o izmišljenim i falsifikovanim podacima o identifikaciji AdipoR1 i AdipoR2.^[9]

Ligandi

Agonisti

Peptidi

Nepeptidi

Antagonisti

Peptid

ADP-400^[10]

Također pogledajte

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000159346 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026457 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T (juni 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762–9. Bibcode:2003Natur.423..762Y. doi:10.1038/nature01705. PMID 12802337. S2CID 52860797.
^ Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD (septembar 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–80. Bibcode:2005JMolE..61..372T. doi:10.1007/s00239-004-0375-2. PMID 16044242. S2CID 31473802.
^ "UniProt, Q96A54" (jezik: en.). Pristupljeno 6. 12. 2021.CS1 održavanje: nepoznati jezik (link)
^ "Entrez Gene: ADIPOR1 adiponectin receptor 1".
^ University of Tokyo to investigate data manipulation charges against six prominent research groups ScienceInsider, Dennis Normile, Sep 20, 2016
^ ^a ^b ^c Otvos L, Knappe D, Hoffmann R, Kovalszky I, Olah J, Hewitson TD, Stawikowska R, Stawikowski M, Cudic P, Lin F, Wade JD, Surmacz E, Lovas S (2014). "Development of second generation peptides modulating cellular adiponectin receptor responses". Frontiers in Chemistry. 2: 93. Bibcode:2014FrCh....2...93O. doi:10.3389/fchem.2014.00093. PMC 4201147. PMID 25368867.
^ Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T (novembar 2013). "A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity". Nature. 503 (7477): 493–9. Bibcode:2013Natur.503..493O. doi:10.1038/nature12656. PMID 24172895. S2CID 4447039.
^ ^a ^b ^c ^d Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z (2013). "Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay". PLOS ONE. 8 (5): e63354. Bibcode:2013PLoSO...863354S. doi:10.1371/journal.pone.0063354. PMC 3653934. PMID 23691032.

Dopunska literatura

Crimmins NA, Martin LJ (septembar 2007). "Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance". Obesity Reviews. 8 (5): 419–23. doi:10.1111/j.1467-789X.2007.00348.x. PMID 17716299. S2CID 825474.
Maruyama K, Sugano S (januar 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (oktobar 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (maj 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T (juni 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762–9. Bibcode:2003Natur.423..762Y. doi:10.1038/nature01705. PMID 12802337. S2CID 52860797.
Kharroubi I, Rasschaert J, Eizirik DL, Cnop M (decembar 2003). "Expression of adiponectin receptors in pancreatic beta cells". Biochemical and Biophysical Research Communications. 312 (4): 1118–22. doi:10.1016/j.bbrc.2003.11.042. PMID 14651988.
Civitarese AE, Jenkinson CP, Richardson D, Bajaj M, Cusi K, Kashyap S, Berria R, Belfort R, DeFronzo RA, Mandarino LJ, Ravussin E (maj 2004). "Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes". Diabetologia. 47 (5): 816–20. doi:10.1007/s00125-004-1359-x. PMID 15105989.
Wang H, Zhang H, Jia Y, Zhang Z, Craig R, Wang X, Elbein SC (august 2004). "Adiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2 diabetes and insulin resistance". Diabetes. 53 (8): 2132–6. doi:10.2337/diabetes.53.8.2132. PMID 15277397.
Staiger H, Kaltenbach S, Staiger K, Stefan N, Fritsche A, Guirguis A, Péterfi C, Weisser M, Machicao F, Stumvoll M, Häring HU (septembar 2004). "Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism". Diabetes. 53 (9): 2195–201. doi:10.2337/diabetes.53.9.2195. PMID 15331527.
Berner HS, Lyngstadaas SP, Spahr A, Monjo M, Thommesen L, Drevon CA, Syversen U, Reseland JE (oktobar 2004). "Adiponectin and its receptors are expressed in bone-forming cells". Bone. 35 (4): 842–9. doi:10.1016/j.bone.2004.06.008. PMID 15454091.
Punyadeera C, Zorenc AH, Koopman R, McAinch AJ, Smit E, Manders R, Keizer HA, Cameron-Smith D, van Loon LJ (mart 2005). "The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle". European Journal of Endocrinology. 152 (3): 427–36. doi:10.1530/eje.1.01872. PMID 15757860.
Hara K, Horikoshi M, Kitazato H, Yamauchi T, Ito C, Noda M, Ohashi J, Froguel P, Tokunaga K, Nagai R, Kadowaki T (juli 2005). "Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes". Diabetologia. 48 (7): 1307–14. doi:10.1007/s00125-005-1806-3. PMID 15918014.
Damcott CM, Ott SH, Pollin TI, Reinhart LJ, Wang J, O'connell JR, Mitchell BD, Shuldiner AR (juli 2005). "Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish". Diabetes. 54 (7): 2245–50. doi:10.2337/diabetes.54.7.2245. PMID 15983228.
Neumeier M, Weigert J, Schäffler A, Weiss T, Kirchner S, Laberer S, Schölmerich J, Buechler C (septembar 2005). "Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors". Biochemical and Biophysical Research Communications. 334 (3): 924–9. doi:10.1016/j.bbrc.2005.06.187. PMID 16023994.
Zhang J, Holt H, Wang C, Hadid OH, Byrne CD (august 2005). "Expression of AdipoR1 in vivo in skeletal muscle is independently associated with measures of truncal obesity in middle-aged caucasian men". Diabetes Care. 28 (8): 2058–60. doi:10.2337/diacare.28.8.2058. PMID 16043761.
Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD (septembar 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–80. Bibcode:2005JMolE..61..372T. doi:10.1007/s00239-004-0375-2. PMID 16044242. S2CID 31473802.
Jonsson JR, Moschen AR, Hickman IJ, Richardson MM, Kaser S, Clouston AD, Powell EE, Tilg H (decembar 2005). "Adiponectin and its receptors in patients with chronic hepatitis C". Journal of Hepatology. 43 (6): 929–36. doi:10.1016/j.jhep.2005.05.030. PMID 16139921.

Vanjski linkovi

Lokacija ljudskog genoma ADIPOR1 i stranica sa detaljima o genu ADIPOR1 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000159346 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026457 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12802337-5] Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T (juni 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762–9. Bibcode:2003Natur.423..762Y. doi:10.1038/nature01705. PMID 12802337. S2CID 52860797.

[TangHu2005-6] Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD (septembar 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–80. Bibcode:2005JMolE..61..372T. doi:10.1007/s00239-004-0375-2. PMID 16044242. S2CID 31473802.

[UniProt-7] "UniProt, Q96A54" (jezik: en.). Pristupljeno 6. 12. 2021.CS1 održavanje: nepoznati jezik (link)

[entrez-8] "Entrez Gene: ADIPOR1 adiponectin receptor 1".

[Dennis-9] University of Tokyo to investigate data manipulation charges against six prominent research groups ScienceInsider, Dennis Normile, Sep 20, 2016

[pmid25368867-10] Otvos L, Knappe D, Hoffmann R, Kovalszky I, Olah J, Hewitson TD, Stawikowska R, Stawikowski M, Cudic P, Lin F, Wade JD, Surmacz E, Lovas S (2014). "Development of second generation peptides modulating cellular adiponectin receptor responses". Frontiers in Chemistry. 2: 93. Bibcode:2014FrCh....2...93O. doi:10.3389/fchem.2014.00093. PMC 4201147. PMID 25368867.

[pmid24172895-11] Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T (novembar 2013). "A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity". Nature. 503 (7477): 493–9. Bibcode:2013Natur.503..493O. doi:10.1038/nature12656. PMID 24172895. S2CID 4447039.

[pmid23691032-12] Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z (2013). "Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay". PLOS ONE. 8 (5): e63354. Bibcode:2013PLoSO...863354S. doi:10.1371/journal.pone.0063354. PMC 3653934. PMID 23691032.

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