OXTR

OXTR
Identifikatori
Aliasi	OXTR
Vanjski ID-jevi	OMIM: 167055 MGI: 109147 HomoloGene: 20255 GeneCards: OXTR
Lokacija gena (miš)
Hrom.	Hromosom 6 (miš)
Kraj	112,466,904 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• G protein-coupled receptor activity; • peptide binding; • signal transducer activity; • peptide hormone binding; • vasopressin receptor activity; • oxytocin receptor activity;
Ćelijska komponenta	• integral component of membrane; • membrana; • ćelijska membrana; • integral component of plasma membrane; • intracellular anatomical structure; • microvillus; • apical plasma membrane;
Biološki proces	• response to cocaine; • positive regulation of synapse assembly; • positive regulation of norepinephrine secretion; • response to cytokine; • maternal process involved in parturition; • response to estradiol; • Mišićna kontrakcija; • response to anoxia; • GO:1904578 response to organic cyclic compound; • eating behavior; • ejakulacija; • estrous cycle; • positive regulation of cytosolic calcium ion concentration; • response to progesterone; • response to amphetamine; • ERK1 and ERK2 cascade; • regulation of systemic arterial blood pressure by vasopressin; • response to steroid hormone; • response to peptide hormone; • negative regulation of gastric acid secretion; • Memorija; • positive regulation of synaptic transmission, GABAergic; • response to peptide; • heart development; • cell surface receptor signaling pathway; • telencephalon development; • Spavanje; • cellular response to hormone stimulus; • positive regulation of blood pressure; • positive regulation of synaptic transmission, glutamatergic; • maternal behavior; • positive regulation of vasoconstriction; • socijalno ponašanje; • positive regulation of penile erection; • lactation; • digestive tract development; • regulation of digestive system process; • GO:0072468 Transdukcija signala; • positive regulation of uterine smooth muscle contraction; • suckling behavior; • female pregnancy; • G protein-coupled receptor signaling pathway; • positive regulation of cold-induced thermogenesis;
	Izvori:Amigo / QuickGO
Ortolozi
	5021
	18430
	ENSG00000180914
	ENSMUSG00000049112
	P30559
	P97926
	NM_000916
	NM_001081147
	NP_000907; NP_001341582; NP_001341583; NP_001341584; NP_001341585
	NP_001074616
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Oksitocinski receptor, znan i kao OXTR, jest protein koji je kod ljudi kodiran genom OXTR sa hromosoma 3. Funkcionira kao receptor za hormone i neurotransmiter oksitocin.^[4]^[5]^[6]^[7]^[8]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 389 aminokiselina, а molekulska težina 42.772 Da.^[10]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MEGALAANWS	AEAANASAAP	PGAEGNRTAG	PPRRNEALAR	VEVAVLCLIL
LLALSGNACV	LLALRTTRQK	HSRLFFFMKH	LSIADLVVAV	FQVLPQLLWD
ITFRFYGPDL	LCRLVKYLQV	VGMFASTYLL	LLMSLDRCLA	ICQPLRSLRR
RTDRLAVLAT	WLGCLVASAP	QVHIFSLREV	ADGVFDCWAV	FIQPWGPKAY
ITWITLAVYI	VPVIVLAACY	GLISFKIWQN	LRLKTAAAAA	AEAPEGAAAG
DGGRVALARV	SSVKLISKAK	IRTVKMTFII	VLAFIVCWTP	FFFVQMWSVW
DANAPKEASA	FIIVMLLASL	NSCCNPWIYM	LFTGHLFHEL	VQRFLCCSAS
YLKGRRLGET	SASKKSNSSS	FVLSHRSSSQ	RSCSQPSTA

Funkcija i lokacija

OXTR protein pripada porodici G-protein spregnutih receptora, konkretno G_q,^[4] i djeluje kao receptor za oksitocin. Njegovu aktivnost posreduje G-protein koji aktivira nekoliko različitih sistema drugog glasnika.^[11]^[12]

Oksitocinski receptori se eksprimiraju u mioepitelnim ćelijama mliječnim žlijezdama, i u miometriju i endometriju maternice na kraju trudnoća. Sistem receptora oksitocin-oksitocin ima važnu ulogu kao induktor kontrakcija maternice tokom porođaja i izbacivanja mlijeka.

OXTR je također povezan sa centralnim nervnim sistemom. Vjeruje se da gen ima glavnu ulogu u društvenom, kognitivnom i emocijskom ponašanju.^[13] Vjeruje se da je povećanje ekspresije ovog gena povezano s neemocijskim osobinama, grubim razmišljanjem i problemima s prepoznavanjem lica i emocija. Također se vjeruje i da smanjenje ekspresije ovog gena dovodi do prenatalnog stresa, postnatalne depresije i socijalne anksioznosti.^[13] Moraju se obaviti dalja istraživanja prije zaključivanja ovih nalaza,ali jaki dokazi upućuju u tom smjeru . OXTR je također u snažnoj korelaciji s amigdalom i odgovorima povezanim sa strahom. Studije sugeriraju da metilacija OXTR-a, koja smanjuje regulaciju oksitocinskih mehanizama, rezultira povećanjem sive tvari u amigdali, što se dalje povezuje sa smanjenjem parasimpatičkog tonusa.^[14]

Kod nekih sisara, oksitocinski receptori se također nalaze u bubrezima i srcu.

Reference

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049112 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Gimpl G, Fahrenholz F (april 2001). "The oxytocin receptor system: structure, function, and regulation". Physiological Reviews. 81 (2): 629–83. doi:10.1152/physrev.2001.81.2.629. PMID 11274341. S2CID 13265083.
^ Zingg HH, Laporte SA (juli 2003). "The oxytocin receptor". Trends in Endocrinology and Metabolism. 14 (5): 222–7. doi:10.1016/S1043-2760(03)00080-8. PMID 12826328. S2CID 21540056.
^ EntrezGene 5021
^ Kimura T, Tanizawa O, Mori K, Brownstein MJ, Okayama H (april 1992). "Structure and expression of a human oxytocin receptor" (PDF). Nature. 356 (6369): 526–9. Bibcode:1992Natur.356..526K. doi:10.1038/356526a0. PMID 1313946. S2CID 4273722. Arhivirano s originala (PDF), 21. 9. 2017. Pristupljeno 4. 11. 2021.
^ Simmons CF, Clancy TE, Quan R, Knoll JH (april 1995). "The oxytocin receptor gene (OXTR) localizes to human chromosome 3p25 by fluorescence in situ hybridization and PCR analysis of somatic cell hybrids". Genomics. 26 (3): 623–5. doi:10.1016/0888-7543(95)80188-R. PMID 7607693.
^ Koehbach J, Stockner T, Bergmayr C, Muttenthaler M, Gruber CW (februar 2013). "Insights into the molecular evolution of oxytocin receptor ligand binding". Biochemical Society Transactions. 41 (1): 197–204. doi:10.1042/BST20120256. PMC 3634130. PMID 23356283.
^ "UniProt, P30559" (jezik: engleski). Pristupljeno 4. 11. 2021.
^ Devost D, Wrzal P, Zingg HH (2008). "Oxytocin receptor signalling". Advances in Vasopressin and Oxytocin — from Genes to Behaviour to Disease. Progress in Brain Research. 170. str. 167–76. doi:10.1016/S0079-6123(08)00415-9. ISBN 978-0-444-53201-5. PMID 18655881.
^ Gimpl G, Reitz J, Brauer S, Trossen C (2008). "Oxytocin receptors: ligand binding, signalling and cholesterol dependence". Advances in Vasopressin and Oxytocin — from Genes to Behaviour to Disease. Progress in Brain Research. 170. str. 193–204. doi:10.1016/S0079-6123(08)00417-2. ISBN 978-0-444-53201-5. PMID 18655883.
^ ^a ^b Maud C, Ryan J, McIntosh JE, Olsson CA (maj 2018). "The role of oxytocin receptor gene (OXTR) DNA methylation (DNAm) in human social and emotional functioning: a systematic narrative review". BMC Psychiatry. 18 (1): 154. doi:10.1186/s12888-018-1740-9. PMC 5975530. PMID 29843655.
^ Lancaster K, Goldbeck L, Puglia MH, Morris JP, Connelly JJ (novembar 2018). "DNA methylation of OXTR is associated with parasympathetic nervous system activity and amygdala morphology". Social Cognitive and Affective Neuroscience. 13 (11): 1155–1162. doi:10.1093/scan/nsy086. PMC 6234329. PMID 30257007.

Vanjski linkovi

Commons logo

Commons ima datoteke na temu: OXTR

Oxytocin receptor na US National Library of Medicine Medical Subject Headings (MeSH)
"Symbol Report: OXTR". HUGO Gene Nomenclature Committee.
"Vasopressin and Oxytocin Receptors: OT". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano s originala, 3. 3. 2016. Pristupljeno 4. 11. 2021.

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

Šablon:Neuropeptidni receptori Šablon:Modulatori oksitocinskih i vazopresinskih receptora

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000049112 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11274341-4] Gimpl G, Fahrenholz F (april 2001). "The oxytocin receptor system: structure, function, and regulation". Physiological Reviews. 81 (2): 629–83. doi:10.1152/physrev.2001.81.2.629. PMID 11274341. S2CID 13265083.

[pmid12826328-5] Zingg HH, Laporte SA (juli 2003). "The oxytocin receptor". Trends in Endocrinology and Metabolism. 14 (5): 222–7. doi:10.1016/S1043-2760(03)00080-8. PMID 12826328. S2CID 21540056.

[NCBI_Gene-6] EntrezGene 5021

[pmid1313946-7] Kimura T, Tanizawa O, Mori K, Brownstein MJ, Okayama H (april 1992). "Structure and expression of a human oxytocin receptor" (PDF). Nature. 356 (6369): 526–9. Bibcode:1992Natur.356..526K. doi:10.1038/356526a0. PMID 1313946. S2CID 4273722. Arhivirano s originala (PDF), 21. 9. 2017. Pristupljeno 4. 11. 2021.

[pmid7607693-8] Simmons CF, Clancy TE, Quan R, Knoll JH (april 1995). "The oxytocin receptor gene (OXTR) localizes to human chromosome 3p25 by fluorescence in situ hybridization and PCR analysis of somatic cell hybrids". Genomics. 26 (3): 623–5. doi:10.1016/0888-7543(95)80188-R. PMID 7607693.

[koechbach2013-9] Koehbach J, Stockner T, Bergmayr C, Muttenthaler M, Gruber CW (februar 2013). "Insights into the molecular evolution of oxytocin receptor ligand binding". Biochemical Society Transactions. 41 (1): 197–204. doi:10.1042/BST20120256. PMC 3634130. PMID 23356283.

[UniProt-10] "UniProt, P30559" (jezik: engleski). Pristupljeno 4. 11. 2021.

[11] Devost D, Wrzal P, Zingg HH (2008). "Oxytocin receptor signalling". Advances in Vasopressin and Oxytocin — from Genes to Behaviour to Disease. Progress in Brain Research. 170. str. 167–76. doi:10.1016/S0079-6123(08)00415-9. ISBN 978-0-444-53201-5. PMID 18655881.

[12] Gimpl G, Reitz J, Brauer S, Trossen C (2008). "Oxytocin receptors: ligand binding, signalling and cholesterol dependence". Advances in Vasopressin and Oxytocin — from Genes to Behaviour to Disease. Progress in Brain Research. 170. str. 193–204. doi:10.1016/S0079-6123(08)00417-2. ISBN 978-0-444-53201-5. PMID 18655883.

[Maud_et_al_2018-13] Maud C, Ryan J, McIntosh JE, Olsson CA (maj 2018). "The role of oxytocin receptor gene (OXTR) DNA methylation (DNAm) in human social and emotional functioning: a systematic narrative review". BMC Psychiatry. 18 (1): 154. doi:10.1186/s12888-018-1740-9. PMC 5975530. PMID 29843655.

[14] Lancaster K, Goldbeck L, Puglia MH, Morris JP, Connelly JJ (novembar 2018). "DNA methylation of OXTR is associated with parasympathetic nervous system activity and amygdala morphology". Social Cognitive and Affective Neuroscience. 13 (11): 1155–1162. doi:10.1093/scan/nsy086. PMC 6234329. PMID 30257007.

[4]

[5]

[6]

[7]

[8]

[1]

[2]

[3]

[9]

[10]

[11]

[12]

[13]

[14]