Wikipedia

NLRC3

NLRC3, skraćeno od NOD-liki receptor porodice CARD domena sa proteinom 3, je unurarćelijski protein koji ima ulogu u imunskom sistemu. To jest protein koji je kod ljudi kodiran genom sa p kraka hromosoma 16.[5] Ranije je bio poznat kao nukleotidnovezujući domen oligomerizacije, ponavljanje bogato leucinom i CARD domen koji sadrži 3 (NOD3) i CLR16.2. NLRC3 inhibira aktivnost T-ćelija.[6] NLRC3 takođe inhibira mTOR signalni put kako bi blokirao ćelijsku proliferaciju.[7]

NLRC3
Identifikatori
AliasiNLRC3
Vanjski ID-jeviOMIM: 615648 MGI: 2444070 HomoloGene: 18720 GeneCards: NLRC3
Lokacija gena (čovjek)
Hromosom 16 (čovjek)
Hrom.Hromosom 16 (čovjek)[1]
Hromosom 16 (čovjek)
Genomska lokacija za NLRC3
Genomska lokacija za NLRC3
Bend16p13.3Početak3,539,033 bp[1]
Kraj3,577,403 bp[1]
Lokacija gena (miš)
Hromosom 16 (miš)
Hrom.Hromosom 16 (miš)[2]
Hromosom 16 (miš)
Genomska lokacija za NLRC3
Genomska lokacija za NLRC3
Bend16|16 A1Početak3,762,871 bp[2]
Kraj3,794,496 bp[2]
Ontologija gena
Molekularna funkcija• nucleotide binding
• ATP binding
• GO:0001948, GO:0016582 vezivanje za proteine
• phosphatidylinositol 3-kinase regulatory subunit binding
• molekularna funkcija
Ćelijska komponenta• citoplazma
• centar organizacije mikrotubula
• citosol
• perinuklearno područje citoplazme
Biološki proces• negative regulation of interleukin-6 production
• negative regulation of tumor necrosis factor production
• I-kappaB kinase/NF-kappaB signaling
• negative regulation of NF-kappaB transcription factor activity
• T cell activation
• negative regulation of I-kappaB kinase/NF-kappaB signaling
• negative regulation of phosphatidylinositol 3-kinase signaling
• negative regulation of interferon-alpha production
• negative regulation of interferon-beta production
• negative regulation of innate immune response
• negative regulation of fibroblast proliferation
• negative regulation of epithelial cell proliferation
• negative regulation of inflammatory response
• negative regulation of cytokine production involved in inflammatory response
• negative regulation of NLRP3 inflammasome complex assembly
• negative regulation of NIK/NF-kappaB signaling
• GO:0007243 intracellular signal transduction
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

197358

268857

Ensembl

ENSG00000167984

ENSMUSG00000049871

UniProt

Q7RTR2

Q5DU56

RefSeq (mRNK)

NM_178844

NM_001081280
NM_175547

RefSeq (bjelančevina)

NP_849172

NP_001074749
NP_780756

Lokacija (UCSC)Chr 16: 3.54 – 3.58 MbChr 16: 3.76 – 3.79 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

uredi

Dužina polipeptidnog lanca je 1 065 aminokiselina, a molekulska težina 114.658 Da[6]

1020304050
MRKQEVRTGREAGQGHGTGSPAEQVKALMDLLAGKGSQGSQAPQALDRTP
DAPLGPCSNDSRIQRHRKALLSKVGGGPELGGPWHRLASLLLVEGLTDLQ
LREHDFTQVEATRGGGHPARTVALDRLFLPLSRVSVPPRVSITIGVAGMG
KTTLVRHFVRLWAHGQVGKDFSLVLPLTFRDLNTHEKLCADRLICSVFPH
VGEPSLAVAVPARALLILDGLDECRTPLDFSNTVACTDPKKEIPVDHLIT
NIIRGNLFPEVSIWITSRPSASGQIPGGLVDRMTEIRGFNEEEIKVCLEQ
MFPEDQALLGWMLSQVQADRALYLMCTVPAFCRLTGMALGHLWRSRTGPQ
DAELWPPRTLCELYSWYFRMALSGEGQEKGKASPRIEQVAHGGRKMVGTL
GRLAFHGLLKKKYVFYEQDMKAFGVDLALLQGAPCSCFLQREETLASSVA
YCFTHLSLQEFVAAAYYYGASRRAIFDLFTESGVSWPRLGFLTHFRSAAQ
RAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSLLAQGEHQAYRTQVAELL
QGCLRPDAAVCARAINVLHCLHELQHTELARSVEEAMESGALARLTGPAH
RAALAYLLQVSDACAQEANLSLSLSQGVLQSLLPQLLYCRKLRLDTNQFQ
DPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLD
LRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNR
TLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAE
ALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEG
AQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWN
FIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALTA
LYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKV
NSSLRRLNLQENSLGMDGAICIATALSGNHRLQHINLQGNHIGDSGARMI
SEAIKTNAPTCTVEM

Reference

uredi
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167984 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049871 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ting JP, Lovering RC, Alnemri ES, et al. (mart 2008). "The NLR gene family: a standard nomenclature". Immunity. 28 (3): 285–7. doi:10.1016/j.immuni.2008.02.005. PMC 2630772. PMID 18341998.
  6. ^ a b Conti BJ, Davis BK, Zhang J, O'connor W, Williams KL, Ting JP (maj 2005). "CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function". J. Biol. Chem. 280 (18): 18375–85. doi:10.1074/jbc.M413169200. PMID 15705585.
  7. ^ Karki, Rajendra; Man, Si Ming; Malireddi, R. K. Subbarao; Kesavardhana, Sannula; Zhu, Qifan; Burton, Amanda R.; Sharma, Bhesh Raj; Qi, Xiaopeng; Pelletier, Stephane; Vogel, Peter; Rosenstiel, Philip (decembar 2016). "NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer". Nature. 540 (7634): 583–587. doi:10.1038/nature20597. ISSN 1476-4687. PMC 5468516. PMID 27951586.

Vanjski linkovi

uredi

Šablon:NOD receptori

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