Kalumenin

Kalumenin je protein koji je kod ljudi kodiran genom CALU.

Kalumenin
Identifikatori
Aliasi	CALU
Vanjski ID-jevi	OMIM: 603420 MGI: 1097158 HomoloGene: 936 GeneCards: CALU
Lokacija gena (čovjek) Hrom. Hromosom 7 (čovjek) Bend 7q32.1 Početak 128,739,292 bp Kraj 128,773,400 bp
Lokacija gena (miš) Hrom. Hromosom 6 (miš) Bend 6|6 A3.3 Početak 29,348,068 bp Kraj 29,377,109 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • calcium ion binding • vezivanje iona metala • GO:0001948, GO:0016582 vezivanje za proteine Ćelijska komponenta • Golđijev aparat • endoplasmic reticulum membrane • membrana • Melanosom • Sarkoplazmatski retikulum • extracellular region • Endoplazmatski retikulum • sarcoplasmic reticulum lumen • endoplasmic reticulum lumen Biološki proces • Posttranslacione modifikacije • GO:0022610 biološki proces Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	813	12321
Ensembl	ENSG00000128595	ENSMUSG00000029767
UniProt	O43852	O35887
RefSeq (mRNK)	NM_001130674 NM_001199671 NM_001199672 NM_001199673 NM_001199674 NM_001219	NM_001285412 NM_007594 NM_184053
RefSeq (bjelančevina)	NP_001124146 NP_001186600 NP_001186601 NP_001186602 NP_001210	NP_001272341 NP_031620 NP_908942
Lokacija (UCSC)	Chr 7: 128.74 – 128.77 Mb	Chr 6: 29.35 – 29.38 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 315 aminokiselina, а molekulska težina 37.107 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MDLRQFLMCL		SLCTAFALSK		PTEKKDRVHH		EPQLSDKVHN		DAQSFDYDHD
AFLGAEEAKT		FDQLTPEESK		ERLGKIVSKI		DGDKDGFVTV		DELKDWIKFA
QKRWIYEDVE		RQWKGHDLNE		DGLVSWEEYK		NATYGYVLDD		PDPDDGFNYK
QMMVRDERRF		KMADKDGDLI		ATKEEFTAFL		HPEEYDYMKD		IVVQETMEDI
DKNADGFIDL		EEYIGDMYSH		DGNTDEPEWV		KTEREQFVEF		RDKNRDGKMD
KEETKDWILP		SDYDHAEAEA		RHLVYESDQN		KDGKLTKEEI		VDKYDLFVGS
QATDFGEALV		RHDEF

Funkcija

Kalumenin (CALU) je protein koji veže kalcij lokaliziran u endoplazmatskom retikulumu (ER) i uključen je u takve funkcije ER, kao što su savijanje proteina i sortiranje. Kalumenin je član natporodice EF-šaka u ER i Golgijevom aparatu pod imenom CERC. CERC je akronim za članove svoje porodice Cab-45, retikulokalbin, Erc-55 (RCN2) i kalumenin. Gen CALU kodira izvedeni protein od 315 aminokiselina, koji sadrži šesr motiva EF-šake, jedno potencijalno mjesto N-glikozilacije i C-terminalni ER signal zadržavanja. CALU proteini čovjeka i miša 98% su identični. CALU iRNK se sveprisutno eksprimira u ljudskim tkivima i mapira nasekvenci 7q32.

Dopunska literatura

• Yabe D, Nakamura T, Kanazawa N, et al. (1997). "Calumenin, a Ca2+-binding protein retained in the endoplasmic reticulum with a novel carboxyl-terminal sequence, HDEF". J. Biol. Chem. 272 (29): 18232–9. doi:10.1074/jbc.272.29.18232. PMID 9218460.
• Vorum H, Liu X, Madsen P, et al. (1998). "Molecular cloning of a cDNA encoding human calumenin, expression in Escherichia coli and analysis of its Ca2+-binding activity". Biochim. Biophys. Acta. 1386 (1): 121–31. doi:10.1016/s0167-4838(98)00089-2. PMID 9675259.
• Hseu MJ, Yen CH, Tzeng MC (1999). "Crocalbin: a new calcium-binding protein that is also a binding protein for crotoxin, a neurotoxic phospholipase A2". FEBS Lett. 445 (2–3): 440–4. doi:10.1016/S0014-5793(99)00177-5. PMID 10094503. S2CID 40129100.
• Vorum H, Hager H, Christensen BM, et al. (1999). "Human calumenin localizes to the secretory pathway and is secreted to the medium". Exp. Cell Res. 248 (2): 473–81. doi:10.1006/excr.1999.4431. PMID 10222138.
• Vorum H, Jacobsen C, Honoré B (2000). "Calumenin interacts with serum amyloid P component". FEBS Lett. 465 (2–3): 129–34. doi:10.1016/S0014-5793(99)01734-2. PMID 10631319. S2CID 1943508.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Basrur V, Yang F, Kushimoto T, et al. (2003). "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins". J. Proteome Res. 2 (1): 69–79. doi:10.1021/pr025562r. PMID 12643545.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.

Vanjski linkovi

• Lokacija ljudskog genoma CALU i stranica sa detaljima o genu CALU u UCSC Genome Browseru.