KDM8

Lizin-demetilaza 8 je protein – enzim koji je kod ljudi kodiran genom KDM8.

KDM8
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 3UYJ, 4AAP, 4GAZ, 4GJY, 4GJZ, 4QU1
Identifikatori
Aliasi	KDM8
Vanjski ID-jevi	OMIM: 611917 MGI: 1924285 HomoloGene: 49791 GeneCards: KDM8
Lokacija gena (čovjek) Hrom. Hromosom 16 (čovjek) Bend 16p12.1 Početak 27,203,508 bp Kraj 27,221,768 bp
Lokacija gena (miš) Hrom. Hromosom 7 (miš) Bend 7|7 F3 Početak 125,043,848 bp Kraj 125,061,441 bp
Ontologija gena Molekularna funkcija • dioxygenase activity • chromatin binding • oxidoreductase activity • vezivanje iona metala • histone H3-methyl-lysine-36 demethylase activity • histone demethylase activity • GO:0001948, GO:0016582 vezivanje za proteine • GO:0070122 peptidase activity • hydrolase activity • aminopeptidase activity • endopeptidase activity • 2-oxoglutarate-dependent dioxygenase activity • methylated histone binding Ćelijska komponenta • jedro • nukleoplazma • citosol • hromosom Biološki proces • GO:0009373 regulation of transcription, DNA-templated • ćelijski ciklus • G2/M transition of mitotic cell cycle • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • histone H3-K36 demethylation • transcription, DNA-templated • Proteoliza • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • protein destabilization • circadian regulation of gene expression • GO:0045996 negative regulation of transcription, DNA-templated • rhythmic process Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	79831	77035
Ensembl	ENSG00000155666	ENSMUSG00000030752
UniProt	Q8N371	Q9CXT6
RefSeq (mRNK)	NM_001145348 NM_024773	NM_029842
RefSeq (bjelančevina)	NP_001138820 NP_079049	NP_084118
Lokacija (UCSC)	Chr 16: 27.2 – 27.22 Mb	Chr 7: 125.04 – 125.06 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Patricia Hartz (2008) mapirala je gen JMJD5 na hromosom 16p12.1, na osnovu poravnanja sekvence JMJD5 (GenBank AK225066) sa genomskom sekvencom (gradnja 36.1).

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 416 aminokiselina, a molekulska težina 47.270 Da.

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MAGDTHCPAE		PLAREGTLWE		ALRALLPHSK		EDLKLDLGEK		VERSVVTLLQ
RATELFYEGR		RDECLQSSEV		ILDYSWEKLN		TGTWQDVDKD		WRRVYAIGCL
LKALCLCQAP		EDANTVAAAL		RVCDMGLLMG		AAILGDILLK		VAAILQTHLP
GKRPARGSLP		EQPCTKKARA		DHGLIPDVKL		EKTVPRLHRP		SLQHFREQFL
VPGRPVILKG		VADHWPCMQK		WSLEYIQEIA		GCRTVPVEVG		SRYTDEEWSQ
TLMTVNEFIS		KYIVNEPRDV		GYLAQHQLFD		QIPELKQDIS		IPDYCSLGDG
EEEEITINAW		FGPQGTISPL		HQDPQQNFLV		QVMGRKYIRL		YSPQESGALY
PHDTHLLHNT		SQVDVENPDL		EKFPKFAKAP		FLSCILSPGE		ILFIPVKYWH
YVRALDLSFS		VSFWWS

Funkcija

Ovaj gen vjerovatno kodira histonsku lizin-demetilazu. Studije sličnih proteina na miševima ukazuju na potencijalnu ulogu ovog proteina kao supresora tumora. Opisane su i alternativno prerađene varijante transkripta.

Dopunska literatura

• Suzuki T, Minehata K, Akagi K, Jenkins NA, Copeland NG (2006). "Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice". EMBO J. 25 (14): 3422–31. doi:10.1038/sj.emboj.7601215. PMC 1523184. PMID 16858412.