IFT122

IFT122
Identifikatori
Aliasi	IFT122
Vanjski ID-jevi	OMIM: 606045 MGI: 1932386 HomoloGene: 12819 GeneCards: IFT122
Lokacija gena (čovjek)
Hrom.	Hromosom 3 (čovjek)
Kraj	129,520,510 bp
Lokacija gena (miš)
Hrom.	Hromosom 6 (miš)
Kraj	115,903,660 bp
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• citoplazma; • ciliary basal body; • projekcija ćelije; • membrana; • intraciliary transport particle A; • photoreceptor connecting cilium; • ciliary base; • ciliary tip; • citoskelet; • nukleoplazma; • citosol; • Treplja;
Biološki proces	• intraciliary anterograde transport; • negative regulation of smoothened signaling pathway; • embryonic body morphogenesis; • embryonic heart tube left/right pattern formation; • embryonic digit morphogenesis; • ciliary receptor clustering involved in smoothened signaling pathway; • negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning; • signal transduction downstream of smoothened; • embryonic heart tube development; • limb development; • multicellular organism development; • neural tube closure; • smoothened signaling pathway involved in dorsal/ventral neural tube patterning; • cell projection organization; • protein localization to cilium; • negative regulation of epithelial cell proliferation; • intraciliary retrograde transport; • establishment of protein localization to organelle; • dorsal/ventral pattern formation; • embryonic forelimb morphogenesis; • camera-type eye morphogenesis; • intraciliary transport involved in cilium assembly; • non-motile cilium assembly; • cilium assembly;
	Izvori:Amigo / QuickGO
Ortolozi
	55764
	81896
	ENSG00000163913
	ENSMUSG00000030323
	Q9HBG6
	Q6NWV3
NM_001280541; NM_001280545; NM_001280546; NM_018262; NM_052985;
	NM_052989; NM_052990
	NM_001167763; NM_031177
NP_001267470; NP_001267474; NP_001267475; NP_060732; NP_443711;
	NP_443715; NP_443716
	NP_001161235; NP_112454
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Međuflagelski transportni protein 122 jest protein koji je kod ljudi kodiran genom IFT122 sa hromosoma 3.^[5]^[6]

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 1.241 aminokiselina, a molekulska težina 141.825 Da.^[5]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MRAVLTWRDK	AEHCINDIAF	KPDGTQLILA	AGSRLLVYDT	SDGTLLQPLK
GHKDTVYCVA	YAKDGKRFAS	GSADKSVIIW	TSKLEGILKY	THNDAIQCVS
YNPITHQLAS	CSSSDFGLWS	PEQKSVSKHK	SSSKIICCSW	TNDGQYLALG
MFNGIISIRN	KNGEEKVKIE	RPGGSLSPIW	SICWNPSSRW	ESFWMNRENE
DAEDVIVNRY	IQEIPSTLKS	AVYSSQGSEA	EEEEPEEEDD	SPRDDNLEER
NDILAVADWG	QKVSFYQLSG	KQIGKDRALN	FDPCCISYFT	KGEYILLGGS
DKQVSLFTKD	GVRLGTVGEQ	NSWVWTCQAK	PDSNYVVVGC	QDGTISFYQL
IFSTVHGLYK	DRYAYRDSMT	DVIVQHLITE	QKVRIKCKEL	VKKIAIYRNR
LAIQLPEKIL	IYELYSEDLS	DMHYRVKEKI	IKKFECNLLV	VCANHIILCQ
EKRLQCLSFS	GVKEREWQME	SLIRYIKVIG	GPPGREGLLV	GLKNGQILKI
FVDNLFAIVL	LKQATAVRCL	DMSASRKKLA	VVDENDTCLV	YDIDTKELLF
QEPNANSVAW	NTQCEDMLCF	SGGGYLNIKA	STFPVHRQKL	QGFVVGYNGS
KIFCLHVFSI	SAVEVPQSAP	MYQYLDRKLF	KEAYQIACLG	VTDTDWRELA
MEALEGLDFE	TAKKAFIRVQ	DLRYLELISS	IEERKKRGET	NNDLFLADVF
SYQGKFHEAA	KLYKRSGHEN	LALEMYTDLC	MFEYAKDFLG	SGDPKETKML
ITKQADWARN	IKEPKAAVEM	YISAGEHVKA	IEICGDHGWV	DMLIDIARKL
DKAEREPLLL	CATYLKKLDS	PGYAAETYLK	MGDLKSLVQL	HVETQRWDEA
FALGEKHPEF	KDDIYMPYAQ	WLAENDRFEE	AQKAFHKAGR	QREAVQVLEQ
LTNNAVAESR	FNDAAYYYWM	LSMQCLDIAQ	DPAQKDTMLG	KFYHFQRLAE
LYHGYHAIHR	HTEDPFSVHR	PETLFNISRF	LLHSLPKDTP	SGISKVKILF
TLAKQSKALG	AYRLARHAYD	KLRGLYIPAR	FQKSIELGTL	TIRAKPFHDS
EELVPLCYRC	STNNPLLNNL	GNVCINCRQP	FIFSASSYDV	LHLVEFYLEE
GITDEEAISL	IDLEVLRPKR	DDRQLEIANN	SSQILRLVET	KDSIGDEDPF
TAKLSFEQGG	SEFVPVVVSR	LVLRSMSRRD	VLIKRWPPPL	RWQYFRSLLP
DASITMCPSC	FQMFHSEDYE	LLVLQHGCCP	YCRRCKDDPG	P

Funkcija uredi

Protein kodiran ovim genom ima za funkciju u razvoju organizma. Učešće u takvim biološkim procesima, kao što je biogeneza i degradacija trepavica, omogučava alternativna prerada, sa izoformama.

Lokaliziran u citoplazmi, citoskeletu, ćelijskim procesima, trepavicama.

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163913 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030323 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "HUGO Gene Nomenclature Commitee, HGNC:13556" (jezik: engleski). Arhivirano s originala, 13. 10. 2017. Pristupljeno 18. 9. 2017.
^ "UniProt, Q9HBG6" (jezik: engleski). Pristupljeno 18. 9. 2017.

Dopunska literatura uredi

Gross C., De Baere E., Lo A., Chang W., Messiaen L. (2001). "Cloning and characterization of human WDR10, a novel gene located at 3q21 encoding a WD-repeat protein that is highly expressed in pituitary and testis". DNA Cell Biol. 20: 41–52.CS1 održavanje: upotreba parametra authors (link) PubMed doi:10.1089/10445490150504684
NIH (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14: 2121–2127. PubMed doi:10.1101/gr.2596504

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163913 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030323 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[HGNC-5] "HUGO Gene Nomenclature Commitee, HGNC:13556" (jezik: engleski). Arhivirano s originala, 13. 10. 2017. Pristupljeno 18. 9. 2017.

[UniProt-6] "UniProt, Q9HBG6" (jezik: engleski). Pristupljeno 18. 9. 2017.

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