HIRIP3

HIRIP3
Identifikatori
Aliasi	HIRIP3
Vanjski ID-jevi	OMIM: 603365 MGI: 2142364 HomoloGene: 18218 GeneCards: HIRIP3
Lokacija gena (čovjek)
Hrom.	Hromosom 16 (čovjek)
Kraj	29,996,074 bp
Lokacija gena (miš)
Hrom.	Hromosom 7 (miš)
Kraj	126,464,549 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ortolozi
	8479
	233876
	ENSG00000149929
	ENSMUSG00000042606
	Q9BW71
	Q8BLH7
	NM_003609; NM_001197323
	NM_172746
	NP_001184252; NP_003600
	NP_766334
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

HIRA-interaktivni protein 3 je protein koji je kod ljudi kodiran genom HIRIP3.^[5]^[6]

Gross (2012) mapirao je je gen HIRIP3 u hromosom 16, sekvenca 16p11.2, na osnovu poravnanja sekvence HIRIP3 (GenBank AJ223349) sa genomskom sekvencom (GRCh37).

Protein HIRA sličan je sekvenci s Hir1p i Hir2p, dva korepresora transkripcije histonskog gena koji se karakteriziraju u kvascu Saccharomyces cerevisiae. Strukturne karakteristike HIRA proteina sugeriraju da može funkcionirati kao dio proteinskog kompleksa. Nedavno je identificirano nekoliko cDNK koje kodiraju HIRA-interaktivne proteine ili HIRIP-ove. In vitro, genski proizvod HIRIP3 veže HIRA, kao i histonska jezgra H2B i H3, što ukazuje da bi kompleks koji sadrži HIRA-HIRIP3 mogao funkcionisati u nekim aspektima metabolizma hromatina i histona.^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 556 aminokiselina, a molekulska težina 61.957 Da.^[7]

10	20	30	40	50
MAREKEMQEF	TRSFFRGRPD	LSTLTHSIVR	RRYLAHSGRS	HLEPEEKQAL
KRLVEEELLK	MQVDEAASRE	DKLDLTKKGK	RPPTPCSDPE	RKRFRFNSES
ESGSEASSPD	YFGPPAKNGV	AAEVSPAKEE	NPRRASKAVE	ESSDEERQRD
LPAQRGEESS	EEEEKGYKGK	TRKKPVVKKQ	APGKASVSRK	QAREESEESE
AEPVQRTAKK	VEGNKGTKSL	KESEQESEEE	ILAQKKEQRE	EEVEEEEKEE
DEEKGDWKPR	TRSNGRRKSA	REERSCKQKS	QAKRLLGDSD	SEEEQKEAAS
SGDDSGRDRE	PPVQRKSEDR	TQLKGGKRLS	GSSEDEEDSG	KGEPTAKGSR
KMARLGSTSG	EESDLEREVS	DSEAGGGPQG	ERKNRSSKKS	SRKGRTRSSS
SSSDGSPEAK	GGKAGSGRRG	EDHPAVMRLK	RYIRACGAHR	NYKKLLGSCC
SHKERLSILR	AELEALGMKG	TPSLGKCRAL	KEQREEAAEV	ASLDVANIIS
GSGRPRRRTA	WNPLGEAAPP	GELYRRTLDS	DEERPRPAPP	DWSHMRGIIS
SDGESN

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000149929 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042606 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lorain S, Quivy JP, Monier-Gavelle F, Scamps C, Lecluse Y, Almouzni G, Lipinski M (Sep 1998). "Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA". Mol Cell Biol. 18 (9): 5546–56. doi:10.1128/MCB.18.9.5546. PMC 109139. PMID 9710638.
^ ^a ^b "Entrez Gene: HIRIP3 HIRA interacting protein 3".
^ "UniProt, Q9BW71". Pristupljeno 6. 7. 2021.

Dopunska literatura uredi

Assrir N, Filhol O, Galisson F, Lipinski M (2007). "HIRIP3 is a nuclear phosphoprotein interacting with and phosphorylated by the serine-threonine kinase CK2". Biol. Chem. 388 (4): 391–8. doi:10.1515/BC.2007.045. PMID 17391060. S2CID 37492665.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000149929 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042606 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9710638-5] Lorain S, Quivy JP, Monier-Gavelle F, Scamps C, Lecluse Y, Almouzni G, Lipinski M (Sep 1998). "Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA". Mol Cell Biol. 18 (9): 5546–56. doi:10.1128/MCB.18.9.5546. PMC 109139. PMID 9710638.

[entrez-6] "Entrez Gene: HIRIP3 HIRA interacting protein 3".

[UniProt-7] "UniProt, Q9BW71". Pristupljeno 6. 7. 2021.

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