Član 1 porodice HemK-metiltransferaza jest enzim koji je kod ljudi kodiran genom HEMK1 sa hromosoma 3.[5]

HEMK1
Identifikatori
AliasiHEMK1
Vanjski ID-jeviMGI: 1916786 HomoloGene: 6815 GeneCards: HEMK1
Lokacija gena (čovjek)
Hromosom 3 (čovjek)
Hrom.Hromosom 3 (čovjek)[1]
Hromosom 3 (čovjek)
Genomska lokacija za HEMK1
Genomska lokacija za HEMK1
Bend3p21.31Početak50,569,152 bp[1]
Kraj50,596,168 bp[1]
Lokacija gena (miš)
Hromosom 9 (miš)
Hrom.Hromosom 9 (miš)[2]
Hromosom 9 (miš)
Genomska lokacija za HEMK1
Genomska lokacija za HEMK1
Bend9|9 F1Početak107,327,084 bp[2]
Kraj107,338,350 bp[2]
Ontologija gena
Molekularna funkcija N-methyltransferase activity
vezivanje sa DNK
nucleic acid binding
GO:0102674, GO:0102675 methyltransferase activity
protein methyltransferase activity
aktivnost sa transferazom
GO:0001948, GO:0016582 vezivanje za proteine
S-adenosylmethionine-dependent methyltransferase activity
protein-(glutamine-N5) methyltransferase activity
Ćelijska komponenta mitohondrija
Biološki proces Metilacija DNK
protein methylation
Metilacija
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)
NM_016173
NM_001317851
NM_001377420
NM_001377421
NM_001377422

NM_001377423
NM_001377424
NM_001377425
NM_001377426
NM_001377427
NM_001377428
NM_001377429

NM_133984

RefSeq (bjelančevina)
NP_001304780
NP_057257
NP_001364349
NP_001364350
NP_001364351

NP_001364352
NP_001364353
NP_001364354
NP_001364355
NP_001364356
NP_001364357
NP_001364358

NP_598745

Lokacija (UCSC)Chr 3: 50.57 – 50.6 MbChr 9: 107.33 – 107.34 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

uredi

Dužina polipeptidnog lanca je 338 aminokiselina, а molekulska težina 38.231 Da.[6]

1020304050
MELWGRMLWALLSGPGRRGSTRGWAFSSWQPQPPLAGLSSAIELVSHWTG
VFEKRGIPEARESSEYIVAHVLGAKTFQSLRPALWTQPLTSQQLQCIREL
SSRRLQRMPVQYILGEWDFQGLSLRMVPPVFIPRPETEELVEWVLEEVAQ
RSHAVGSPGSPLILEVGCGSGAISLSLLSQLPQSRVIAVDKREAAISLTH
ENAQRLRLQDRIWIIHLDMTSERSWTHLPWGPMDLIVSNPPYVFHQDMEQ
LAPEIRSYEDPAALDGGEEGMDIITHILALAPRLLKDSGSIFLEVDPRHP
ELVSSWLQSRPDLYLNLVAVRRDFCGRPRFLHIRRSGP

Reference

uredi
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114735 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032579 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: HemK methyltransferase family member 1". Pristupljeno 25. 9. 2015.
  6. ^ "UniProt, Q9Y5R4" (jezik: engleski). Pristupljeno 4. 11. 2021.

Vanjski linkovi

uredi