AGPAT9
(Preusmjereno sa GPAT-3)
Glicerol-3-fosfat aciltransferaza 3 (GPAT-3) jest enzim koji je kod ljudi kodiran genom AGPAT9 sa hromosoma 4.[5][6][7][8] GPAT-3 je znana u kao :
- 1-acilglicerol-3-fosfat O-aciltransferaza 9 (AGPAT9),
- lizofosfatidna kisela aciltransferaza teta (LPAAT-teta), ili
- pridruženi protein 1 metastazi raka pluća.
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 434 aminokiseline, а molekulska težina 48.705 Da.[9]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MEGAELAGKI | LSTWLTLVLG | FILLPSVFGV | SLGISEIYMK | ILVKTLEWAT | ||||
| IRIEKGTPKE | SILKNSASVG | IIQRDESPME | KGLSGLRGRD | FELSDVFYFS | ||||
| KKGLEAIVED | EVTQRFSSEE | LVSWNLLTRT | NVNFQYISLR | LTMVWVLGVI | ||||
| VRYCVLLPLR | VTLAFIGISL | LVIGTTLVGQ | LPDSSLKNWL | SELVHLTCCR | ||||
| ICVRALSGTI | HYHNKQYRPQ | KGGICVANHT | SPIDVLILTT | DGCYAMVGQV | ||||
| HGGLMGIIQR | AMVKACPHVW | FERSEMKDRH | LVTKRLKEHI | ADKKKLPILI | ||||
| FPEGTCINNT | SVMMFKKGSF | EIGGTIHPVA | IKYNPQFGDA | FWNSSKYNMV | ||||
| SYLLRMMTSW | AIVCDVWYMP | PMTREEGEDA | VQFANRVKSA | IAIQGGLTEL | ||||
| PWDGGLKRAK | VKDIFKEEQQ | KNYSKMIVGN | GSLS |
Funkcija
urediGlicerol-3-fosfat (G3P) aciltransferaze (GPAT; EC 2.3.1.15), kao što su GPAM i GPAT3 (ovaj enzim), kataliziraju početni korak de novo sinteze triacilglicerola (TAG), pretvaranjem glicerol-3-fosfata (G3P) do lizofosfatidne kiseline (LPA).[6]
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000138678 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029314 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Clark HF, Gurney AL, Abaya E, et al. (oktobar 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- ^ a b Cao J, Li JL, Li D, Tobin JF, Gimeno RE (decembar 2006). "Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis". Proc. Natl. Acad. Sci. U.S.A. 103 (52): 19695–700. doi:10.1073/pnas.0609140103. PMC 1702318. PMID 17170135.
- ^ Tang W, Yuan J, Chen X, Gu X, Luo K, Li J, Wan B, Wang Y, Yu L (septembar 2006). "Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway". J. Biochem. Mol. Biol. 39 (5): 626–35. doi:10.5483/BMBRep.2006.39.5.626. PMID 17002884.
- ^ "Entrez Gene: AGPAT9: 1-acylglycerol-3-phosphate O-acyltransferase 9".
- ^ "UniProt, Q53EU6" (jezik: engleski). Pristupljeno 21. 10. 2021.
Dopunska literatura
uredi- Tang W, Yuan J, Chen X, et al. (2006). "Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway". J. Biochem. Mol. Biol. 39 (5): 626–35. doi:10.5483/BMBRep.2006.39.5.626. PMID 17002884.
- Yamada S, Ohira M, Horie H, et al. (2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas". Oncogene. 23 (35): 5901–11. doi:10.1038/sj.onc.1207782. PMID 15221005.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Vanjski linkovi
urediOvaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.
- Lokacija ljudskog genoma GPAT3 i stranica sa detaljima o genu GPAT3 u UCSC Genome Browseru.