FGL1

FGL1
Identifikatori
Aliasi	FGL1
Vanjski ID-jevi	OMIM: 605776 MGI: 102795 HomoloGene: 37927 GeneCards: FGL1
Lokacija gena (čovjek)
Hrom.	Hromosom 8 (čovjek)
Kraj	17,910,365 bp
Lokacija gena (miš)
Hrom.	Hromosom 8 (miš)
Kraj	41,668,193 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ortolozi
	2267
	234199
	ENSG00000104760
	ENSMUSG00000031594
	Q08830
	Q71KU9
	NM_201553; NM_004467; NM_147203; NM_201552
	NM_145594
	NP_004458; NP_671736; NP_963846; NP_963847
	NP_663569
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Fibrinogenoliki protein 1 (FGL-1) je protein koji je strukturno sličan fibrinogenu. Kod ljudi kodiran je genom FGL1.^[5]^[6] Odgovarajući gen ima ćetiri prerađene varijante.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 312 aminokiselina, а molekulska težina 36.379 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAKVFSFILV	TTALTMGREI	SALEDCAQEQ	MRLRAQVRLL	ETRVKQQQVK
IKQLLQENEV	QFLDKGDENT	VIDLGSKRQY	ADCSEIFNDG	YKLSGFYKIK
PLQSPAEFSV	YCDMSDGGGW	TVIQRRSDGS	ENFNRGWKDY	ENGFGNFVQK
HGEYWLGNKN	LHFLTTQEDY	TLKIDLADFE	KNSRYAQYKN	FKVGDEKNFY
ELNIGEYSGT	AGDSLAGNFH	PEVQWWASHQ	RMKFSTWDRD	HDNYEGNCAE
EDQSGWWFNR	CHSANLNGVY	YSGPYTAKTD	NGIVWYTWHG	WWYSLKSVVM
KIRPNDFIPN	VI

Funkcija

Protein 1 sličan fibrinogenu je član proteinske porodice fibrinogena, koja također uključuje fibrinogen, protein sličan fibrinogenu 2 i faktore zgrušavanja V, VIII i XIII. FGL-1 je homologan karboksi-terminalu fibrinogena beta– i gama– podjedinica koja sadrži četiri konzervirana cisteina koji su zajednički svim članovima porodice fibrinogena. Međutim, FGL-1 nema mjesto vezanja trombocita, područje umrežavanja i trombin-osjetljivo mjesto koje dopušta ostalim članovima porodice fibrinogena da pomognu u stvaranju fibrinskog ugrušaka.^[6]

Uočeno je i da se FGL-1 snažno veže i aktivira LAG-3, regulatorni protein eksprimiran na T-ćelijama. Budući da LAG-3 ima važnu ulogu u kontroli aktiviracije T-ćelija. Manipulacija vezivanja FGL-1 za T-ćelije predložena je i za imunoterapiju protiv kancera i za protivupalno liječenje.^[8]

Klinički značaj

FGL-1 može imati ulogu u razvoju hepatoćelijskog karcinoma.^[6]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104760 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031594 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yamamoto T, Gotoh M, Sasaki H, Terada M, Kitajima M, Hirohashi S (Jul 1993). "Molecular cloning and initial characterization of a novel fibrinogen-related gene, HFREP-1". Biochem Biophys Res Commun. 193 (2): 681–7. doi:10.1006/bbrc.1993.1678. PMID 8390249.
^ ^a ^b ^c "Entrez Gene: FGL1 fibrinogen-like 1".
^ "UniProt, Q08830" (jezik: engleski). Pristupljeno 18. 9. 2021.
^ Wang J, Sanmamed MF, Datar I, Su TT, Ji L, Sun J, et al. (januar 2019). "Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3". Cell. 176 (1–2): 334–347.e12. doi:10.1016/j.cell.2018.11.010. PMC 6365968. PMID 30580966.

Dopunska literatura

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hara H, Yoshimura H, Uchida S, et al. (2001). "Molecular cloning and functional expression analysis of a cDNA for human hepassocin, a liver-specific protein with hepatocyte mitogenic activity". Biochim. Biophys. Acta. 1520 (1): 45–53. doi:10.1016/s0167-4781(01)00249-4. PMID 11470158.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zeng L, Dai J, Ying K, et al. (2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart". J. Hum. Genet. 48 (3): 159–62. doi:10.1007/s100380300025. PMID 12624729.
Yan J, Yu Y, Wang N, et al. (2004). "LFIRE-1/HFREP-1, a liver-specific gene, is frequently downregulated and has growth suppressor activity in hepatocellular carcinoma". Oncogene. 23 (10): 1939–49. doi:10.1038/sj.onc.1207306. PMID 14981537.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Rijken DC, Dirkx SP, Luider TM, Leebeek FW (2006). "Hepatocyte-derived fibrinogen-related protein-1 is associated with the fibrin matrix of a plasma clot". Biochem. Biophys. Res. Commun. 350 (1): 191–4. doi:10.1016/j.bbrc.2006.09.018. PMID 16996032.
Liu Z, Ukomadu C (2008). "Fibrinogen-like protein 1, a hepatocyte derived protein is an acute phase reactant". Biochem. Biophys. Res. Commun. 365 (4): 729–34. doi:10.1016/j.bbrc.2007.11.069. PMC 2288651. PMID 18039467.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104760 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031594 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8390249-5] Yamamoto T, Gotoh M, Sasaki H, Terada M, Kitajima M, Hirohashi S (Jul 1993). "Molecular cloning and initial characterization of a novel fibrinogen-related gene, HFREP-1". Biochem Biophys Res Commun. 193 (2): 681–7. doi:10.1006/bbrc.1993.1678. PMID 8390249.

[entrez-6] "Entrez Gene: FGL1 fibrinogen-like 1".

[UniProt-7] "UniProt, Q08830" (jezik: engleski). Pristupljeno 18. 9. 2021.

[pmid30580966-8] Wang J, Sanmamed MF, Datar I, Su TT, Ji L, Sun J, et al. (januar 2019). "Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3". Cell. 176 (1–2): 334–347.e12. doi:10.1016/j.cell.2018.11.010. PMC 6365968. PMID 30580966.

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