EDEM3
(Preusmjereno sa ER-pojačavački protein 3 degradacije alfa-manozidaze)
ER pojačavački protein 3 degradacije alfa-manozidaze jest enzim koji je kod ljudi kodiran genom EDEM3 sa hromosoma 1.[5][6][7]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 932 aminokiselina, a molekulska težina 104.664Da.[8]
10 | 20 | 30 | 40 | 50 | ||||
---|---|---|---|---|---|---|---|---|
MSEAGGRGCG | SPVPQRARWR | LVAATAAFCL | VSATSVWTAG | AEPMSREEKQ | ||||
KLGNQVLEMF | DHAYGNYMEH | AYPADELMPL | TCRGRVRGQE | PSRGDVDDAL | ||||
GKFSLTLIDS | LDTLVVLNKT | KEFEDAVRKV | LRDVNLDNDV | VVSVFETNIR | ||||
VLGGLLGGHS | LAIMLKEKGE | YMQWYNDELL | QMAKQLGYKL | LPAFNTTSGL | ||||
PYPRINLKFG | IRKPEARTGT | ETDTCTACAG | TLILEFAALS | RFTGATIFEE | ||||
YARKALDFLW | EKRQRSSNLV | GVTINIHTGD | WVRKDSGVGA | GIDSYYEYLL | ||||
KAYVLLGDDS | FLERFNTHYD | AIMRYISQPP | LLLDVHIHKP | MLNARTWMDA | ||||
LLAFFPGLQV | LKGDIRPAIE | THEMLYQVIK | KHNFLPEAFT | TDFRVHWAQH | ||||
PLRPEFAEST | YFLYKATGDP | YYLEVGKTLI | ENLNKYARVP | CGFAAMKDVR | ||||
TGSHEDRMDS | FFLAEMFKYL | YLLFADKEDI | IFDIEDYIFT | TEAHLLPLWL | ||||
STTNQSISKK | NTTSEYTELD | DSNFDWTCPN | TQILFPNDPL | YAQSIREPLK | ||||
NVVDKSCPRG | IIRVEESFRS | GAKPPLRARD | FMATNPEHLE | ILKKMGVSLI | ||||
HLKDGRVQLV | QHAIQAASSI | DAEDGLRFMQ | EMIELSSQQQ | KEQQLPPRAV | ||||
QIVSHPFFGR | VVLTAGPAQF | GLDLSKHKET | RGFVASSKPS | NGCSELTNPE | ||||
AVMGKIALIQ | RGQCMFAEKA | RNIQNAGAIG | GIVIDDNEGS | SSDTAPLFQM | ||||
AGDGKDTDDI | KIPMLFLFSK | EGSIILDAIR | EYEEVEVLLS | DKAKDRDPEM | ||||
ENEEQPSSEN | DSQNQSGEQI | SSSSQEVDLV | DQESSEENSL | NSHPESLSLA | ||||
DMDNAASISP | SEQTSNPTEN | HETTNLNGEC | TDLDNQLQEQ | SETEEDSNPN | ||||
VSWGKKVQPI | DSILADWNED | IEAFEMMEKD | EL |
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000116406 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043019 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mast SW, Diekman K, Karaveg K, Davis A, Sifers RN, Moremen KW (Mar 2005). "Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins". Glycobiology. 15 (4): 421–36. doi:10.1093/glycob/cwi014. PMID 15537790.
- ^ Olivari S, Galli C, Alanen H, Ruddock L, Molinari M (Jan 2005). "A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation". J Biol Chem. 280 (4): 2424–8. doi:10.1074/jbc.C400534200. PMID 15579471.
- ^ "Entrez Gene: EDEM3 ER degradation enhancer, mannosidase alpha-like 3".
- ^ "UniProt, Q9BZQ6" (jezik: en.). Pristupljeno 10. 12. 2021.CS1 održavanje: nepoznati jezik (link)
Dopunska literatura
uredi- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Sood R, Bonner TI, Makalowska I, et al. (2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics. 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Hirao K, Natsuka Y, Tamura T, et al. (2006). "EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming". J. Biol. Chem. 281 (14): 9650–8. doi:10.1074/jbc.M512191200. PMID 16431915.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.