ER pojačavački protein 3 degradacije alfa-manozidaze jest enzim koji je kod ljudi kodiran genom EDEM3 sa hromosoma 1.[5][6][7]

EDEM3
Identifikatori
AliasiEDEM3
Vanjski ID-jeviOMIM: 610214 MGI: 1914217 HomoloGene: 11866 GeneCards: EDEM3
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za EDEM3
Genomska lokacija za EDEM3
Bend1q25.3Početak184,690,237 bp[1]
Kraj184,754,907 bp[1]
Lokacija gena (miš)
Hromosom 1 (miš)
Hrom.Hromosom 1 (miš)[2]
Hromosom 1 (miš)
Genomska lokacija za EDEM3
Genomska lokacija za EDEM3
Bend1|1 G2Početak151,631,122 bp[2]
Kraj151,697,802 bp[2]
Obrazac RNK ekspresije


Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija calcium ion binding
hydrolase activity
vezivanje iona metala
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
catalytic activity
Ćelijska komponenta endoplasmic reticulum lumen
Endoplazmatski retikulum
membrana
endoplasmic reticulum quality control compartment
Biološki proces endoplasmic reticulum unfolded protein response
GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation
N-glycan processing
response to unfolded protein
glycoprotein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
mannose trimming involved in glycoprotein ERAD pathway
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_025191
NM_001319960

NM_001039644
NM_001311165
NM_001311166

RefSeq (bjelančevina)

NP_001306889
NP_079467

NP_001034733
NP_001298094
NP_001298095

Lokacija (UCSC)Chr 1: 184.69 – 184.75 MbChr 1: 151.63 – 151.7 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 932 aminokiselina, a molekulska težina 104.664Da.[8]

1020304050
MSEAGGRGCGSPVPQRARWRLVAATAAFCLVSATSVWTAGAEPMSREEKQ
KLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDAL
GKFSLTLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIR
VLGGLLGGHSLAIMLKEKGEYMQWYNDELLQMAKQLGYKLLPAFNTTSGL
PYPRINLKFGIRKPEARTGTETDTCTACAGTLILEFAALSRFTGATIFEE
YARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLL
KAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDA
LLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQH
PLRPEFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVR
TGSHEDRMDSFFLAEMFKYLYLLFADKEDIIFDIEDYIFTTEAHLLPLWL
STTNQSISKKNTTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIREPLK
NVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPEHLEILKKMGVSLI
HLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAV
QIVSHPFFGRVVLTAGPAQFGLDLSKHKETRGFVASSKPSNGCSELTNPE
AVMGKIALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQM
AGDGKDTDDIKIPMLFLFSKEGSIILDAIREYEEVEVLLSDKAKDRDPEM
ENEEQPSSENDSQNQSGEQISSSSQEVDLVDQESSEENSLNSHPESLSLA
DMDNAASISPSEQTSNPTENHETTNLNGECTDLDNQLQEQSETEEDSNPN
VSWGKKVQPIDSILADWNEDIEAFEMMEKDEL

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116406 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043019 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mast SW, Diekman K, Karaveg K, Davis A, Sifers RN, Moremen KW (Mar 2005). "Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins". Glycobiology. 15 (4): 421–36. doi:10.1093/glycob/cwi014. PMID 15537790.
  6. ^ Olivari S, Galli C, Alanen H, Ruddock L, Molinari M (Jan 2005). "A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation". J Biol Chem. 280 (4): 2424–8. doi:10.1074/jbc.C400534200. PMID 15579471.
  7. ^ "Entrez Gene: EDEM3 ER degradation enhancer, mannosidase alpha-like 3".
  8. ^ "UniProt, Q9BZQ6" (jezik: en.). Pristupljeno 10. 12. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

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