CXCL11

Hemokinski ligand 11 (C-X-C motiv) jest protein koji je kod ljudi kodiran genom CXCL11 sa hromosoma 4.

CXCL11
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1RJT
Identifikatori
Aliasi	CXCL11
Vanjski ID-jevi	OMIM: 604852 MGI: 1860203 HomoloGene: 3944 GeneCards: CXCL11
Lokacija gena (čovjek) Hrom. Hromosom 4 (čovjek) Bend 4q21.1 Početak 76,033,682 bp Kraj 76,041,415 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • chemokine activity • cytokine activity • heparin binding • GO:0001948, GO:0016582 vezivanje za proteine • CXCR3 chemokine receptor binding Ćelijska komponenta • extracellular region • Vanćelijsko • intracellular anatomical structure Biološki proces • Hemotaksija • positive regulation of leukocyte chemotaxis • T cell chemotaxis • chemokine-mediated signaling pathway • response to lipopolysaccharide • cell-cell signaling • positive regulation of release of sequestered calcium ion into cytosol • positive regulation of cAMP-mediated signaling • regulation of cell population proliferation • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor • GO:0072468 Transdukcija signala • defense response • inflammatory response • antimicrobial humoral immune response mediated by antimicrobial peptide • regulation of signaling receptor activity • G protein-coupled receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • neutrophil chemotaxis • leukocyte chemotaxis • cellular response to lipopolysaccharide Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	6373	56066
Ensembl	ENSG00000169248	ENSMUSG00000060183
UniProt	O14625	Q9JHH5
RefSeq (mRNK)	NM_005409 NM_001302123	NM_019494
RefSeq (bjelančevina)	NP_001289052 NP_005400	NP_062367
Lokacija (UCSC)	Chr 4: 76.03 – 76.04 Mb	n/a
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

C-X-C motivni hemokin 11 je mali citokin porodice hemokina CXC, znani kao interferon induciblni T-ćelijski alfa hemoatratant (I-TAC) i "interferon-gama-inducibilni protein 9" (IP-9). Vrlo je eksprimiran u leukocitima periferne krvi, gušterači i jetri, s umjerenim nivoima u timusu, slezeni i plućima i niskim nivoima ekspresijw u tankom crevu, placenti i prostati.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 94 aminokiseline, а molekulska težina 10.365 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MSVKGMAIAL		AVILCATVVQ		GFPMFKRGRC		LCIGPGVKAV		KVADIEKASI
MYPSNNCDKI		EVIITLKENK		GQRCLNPKSK		QARLIIKKVE		RKNF

Funkcija

Ekspresija gena CXCL11 je snažno indukovana interferonima tipa II, IFN-γ i IFN-β, a slabo indukovana iinterferonom IFN-α. Ovaj hemokin izaziva efekte na svoje ciljne ćelije interakcijom sa ćelijskom površinom receptorom hemokina CXCR3, sa većim afinitetom nego drugi ligandi za ovaj receptor, CXCL9 i CXCL10. CXCL11 je hemotaksičan za aktivirane T-ćelije . Na ljudskom hromosomu 4, njegov gen nalazi se zajedno sa mnogim drugim članovima porodice hemokina CXC.

Biomarkeri

CXCL9, CXCL-10 i CXCL-11 pokazali su se kao valjani biomarkeri za razvoj srčane insuficijencije i disfunkcije lijeve komore, ukazujući na potcrtavajuću patofiziološku vezu između nivoa ovih hemokina i razvoja štetnog preoblikovanja srca.

Dopunska literatura

• Rani MR, Foster GR, Leung S, Leaman D, Stark GR, Ransohoff RM (septembar 1996). "Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha". The Journal of Biological Chemistry. 271 (37): 22878–84. doi:10.1074/jbc.271.37.22878. PMID 8798467.
• Jacobs KA, Collins-Racie LA, Colbert M, Duckett M, Golden-Fleet M, Kelleher K, Kriz R, LaVallie ER, Merberg D, Spaulding V, Stover J, Williamson MJ, McCoy JM (oktobar 1997). "A genetic selection for isolating cDNAs encoding secreted proteins". Gene. 198 (1–2): 289–96. doi:10.1016/S0378-1119(97)00330-2. PMID 9370294.
• Cole KE, Strick CA, Paradis TJ, Ogborne KT, Loetscher M, Gladue RP, Lin W, Boyd JG, Moser B, Wood DE, Sahagan BG, Neote K (juni 1998). "Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3". The Journal of Experimental Medicine. 187 (12): 2009–21. doi:10.1084/jem.187.12.2009. PMC 2212354. PMID 9625760.
• Erdel M, Laich A, Utermann G, Werner ER, Werner-Felmayer G (1998). "The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10)". Cytogenetics and Cell Genetics. 81 (3–4): 271–2. doi:10.1159/000015043. PMID 9730616. S2CID 46846304.
• Luo Y, Kim R, Gabuzda D, Mi S, Collins-Racie LA, Lu Z, Jacobs KA, Dorf ME (decembar 1998). "The CXC-chemokine, H174: expression in the central nervous system". Journal of Neurovirology. 4 (6): 575–85. doi:10.3109/13550289809114224. PMID 10065899.
• Tensen CP, Flier J, Van Der Raaij-Helmer EM, Sampat-Sardjoepersad S, Van Der Schors RC, Leurs R, Scheper RJ, Boorsma DM, Willemze R (maj 1999). "Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)". The Journal of Investigative Dermatology. 112 (5): 716–22. doi:10.1046/j.1523-1747.1999.00581.x. PMID 10233762.
• Laich A, Meyer M, Werner ER, Werner-Felmayer G (maj 1999). "Structure and expression of the human small cytokine B subfamily member 11 (SCYB11/formerly SCYB9B, alias I-TAC) gene cloned from IFN-gamma-treated human monocytes (THP-1)". Journal of Interferon & Cytokine Research. 19 (5): 505–13. doi:10.1089/107999099313956. PMID 10386863.
• Tensen CP, Flier J, Rampersad SS, Sampat-Sardjoepersad S, Scheper RJ, Boorsma DM, Willemze R (juli 1999). "Genomic organization, sequence and transcriptional regulation of the human CXCL 11(1) gene". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1446 (1–2): 167–72. doi:10.1016/s0167-4781(99)00084-6. PMID 10395932.
• Loetscher P, Pellegrino A, Gong JH, Mattioli I, Loetscher M, Bardi G, Baggiolini M, Clark-Lewis I (februar 2001). "The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3". The Journal of Biological Chemistry. 276 (5): 2986–91. doi:10.1074/jbc.M005652200. PMID 11110785.
• Lambeir AM, Proost P, Durinx C, Bal G, Senten K, Augustyns K, Scharpé S, Van Damme J, De Meester I (august 2001). "Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family". The Journal of Biological Chemistry. 276 (32): 29839–45. doi:10.1074/jbc.M103106200. PMID 11390394.
• Hensbergen PJ, van der Raaij-Helmer EM, Dijkman R, van der Schors RC, Werner-Felmayer G, Boorsma DM, Scheper RJ, Willemze R, Tensen CP (septembar 2001). "Processing of natural and recombinant CXCR3-targeting chemokines and implications for biological activity". European Journal of Biochemistry. 268 (18): 4992–9. doi:10.1046/j.0014-2956.2001.02433.x. PMID 11559369.
• Mohan K, Ding Z, Hanly J, Issekutz TB (juni 2002). "IFN-gamma-inducible T cell alpha chemoattractant is a potent stimulator of normal human blood T lymphocyte transendothelial migration: differential regulation by IFN-gamma and TNF-alpha". Journal of Immunology. 168 (12): 6420–8. doi:10.4049/jimmunol.168.12.6420. PMID 12055261.
• Basu S, Schaefer TM, Ghosh M, Fuller CL, Reinhart TA (maj 2002). "Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, AND CX3C families of chemokines". Cytokine. 18 (3): 140–8. doi:10.1006/cyto.2002.0875. PMID 12126650.
• Salmaggi A, Gelati M, Dufour A, Corsini E, Pagano S, Baccalini R, Ferrero E, Scabini S, Silei V, Ciusani E, De Rossi M (juni 2002). "Expression and modulation of IFN-gamma-inducible chemokines (IP-10, Mig, and I-TAC) in human brain endothelium and astrocytes: possible relevance for the immune invasion of the central nervous system and the pathogenesis of multiple sclerosis". Journal of Interferon & Cytokine Research. 22 (6): 631–40. doi:10.1089/10799900260100114. PMID 12162873.
• Rani MR, Hibbert L, Sizemore N, Stark GR, Ransohoff RM (oktobar 2002). "Requirement of phosphoinositide 3-kinase and Akt for interferon-beta-mediated induction of the beta-R1 (SCYB11) gene". The Journal of Biological Chemistry. 277 (41): 38456–61. doi:10.1074/jbc.M203204200. PMID 12169689.
• Kao J, Kobashigawa J, Fishbein MC, MacLellan WR, Burdick MD, Belperio JA, Strieter RM (april 2003). "Elevated serum levels of the CXCR3 chemokine ITAC are associated with the development of transplant coronary artery disease". Circulation. 107 (15): 1958–61. doi:10.1161/01.CIR.0000069270.16498.75. PMID 12695288.
• Satish L, Yager D, Wells A (juni 2003). "Glu-Leu-Arg-negative CXC chemokine interferon gamma inducible protein-9 as a mediator of epidermal-dermal communication during wound repair". The Journal of Investigative Dermatology. 120 (6): 1110–7. doi:10.1046/j.1523-1747.2003.12230.x. PMID 12787142.
• Klunker S, Trautmann A, Akdis M, Verhagen J, Schmid-Grendelmeier P, Blaser K, Akdis CA (juli 2003). "A second step of chemotaxis after transendothelial migration: keratinocytes undergoing apoptosis release IFN-gamma-inducible protein 10, monokine induced by IFN-gamma, and IFN-gamma-inducible alpha-chemoattractant for T cell chemotaxis toward epidermis in atopic dermatitis". Journal of Immunology. 171 (2): 1078–84. doi:10.4049/jimmunol.171.2.1078. PMID 12847282.
• Xanthou G, Duchesnes CE, Williams TJ, Pease JE (august 2003). "CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11". European Journal of Immunology. 33 (8): 2241–50. doi:10.1002/eji.200323787. PMID 12884299. S2CID 24555816.

Vanjski linkovi

• Lokacija ljudskog genoma CXCL11 i stranica sa detaljima o genu CXCL11 u UCSC Genome Browseru.