CRYZ
Kinon-oksidoreduktaza jest enzim koji je kod ljudi kodiran genom CRYZ sa hromosoma 1.[5]
Aminokiselinska sekvenca uredi
Dužina polipeptidnog lanca je 329 aminokiselina, a molekulska težina 35.207 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MATGQKLMRA | VRVFEFGGPE | VLKLRSDIAV | PIPKDHQVLI | KVHACGVNPV | ||||
| ETYIRSGTYS | RKPLLPYTPG | SDVAGVIEAV | GDNASAFKKG | DRVFTSSTIS | ||||
| GGYAEYALAA | DHTVYKLPEK | LDFKQGAAIG | IPYFTAYRAL | IHSACVKAGE | ||||
| SVLVHGASGG | VGLAACQIAR | AYGLKILGTA | GTEEGQKIVL | QNGAHEVFNH | ||||
| REVNYIDKIK | KYVGEKGIDI | IIEMLANVNL | SKDLSLLSHG | GRVIVVGSRG | ||||
| TIEINPRDTM | AKESSIIGVT | LFSSTKEEFQ | QYAAALQAGM | EIGWLKPVIG | ||||
| SQYPLEKVAE | AHENIIHGSG | ATGKMILLL |
Funkcija uredi
Kristalini se dijele u dvije klase: specifične za taksone ili enzime i sveprisutne. Potonja klasa čini glavne proteine kičmenjaka očne leće i održava transparentnost i indeks prelamanja sočiva. Prva klasa se naziva i filogenetski ograničeni kristalini. Ovaj gen kodira kristalinski protein specifičan za takson koji ima NADPH-ovisnu aktivnost kinon-reduktaze, različitu od drugih poznatih kinon-reduktaza. Nedostaje mu aktivnost alkohol-dehidrogenaza, iako se po sličnosti smatra članom porodice alkohol-dehidrogenaza koje sadrže cink. Za razliku od drugih sisarskih vrsta, kod ljudskih sočiva ekspresija je niska. Poznato je da postoji jedan pseudogen.[5]
Reference uredi
- ^ a b c GRCh38: Ensembl release 89: ENSG00000116791 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028199 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: CRYZ crystallin, zeta (quinone reductase)".
- ^ "UniProt, Q08257" (jezik: engleski). Pristupljeno 23. 11. 2021.
Dopunska literatura uredi
- Heinzmann C, Kojis TL, Gonzalez P, et al. (1995). "Assignment of the zeta-crystallin gene (CRYZ) to human chromosome 1p22-p31 and identification of restriction fragment length polymorphisms". Genomics. 23 (2): 403–7. doi:10.1006/geno.1994.1516. PMID 7835889.
- Gonzalez P, Rao PV, Zigler JS (1994). "Organization of the human zeta-crystallin/quinone reductase gene (CRYZ)". Genomics. 21 (2): 317–24. doi:10.1006/geno.1994.1272. PMID 8088825.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Gonzalez P, Rao PV, Zigler JS (1993). "Molecular cloning and sequencing of zeta-crystallin/quinone reductase cDNA from human liver". Biochem. Biophys. Res. Commun. 191 (3): 902–7. doi:10.1006/bbrc.1993.1302. PMID 8466529.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Wang W, Liu LQ, Higuchi CM, Chen H (1998). "Induction of NADPH:quinone reductase by dietary phytoestrogens in colonic Colo205 cells". Biochem. Pharmacol. 56 (2): 189–95. doi:10.1016/S0006-2952(98)00141-5. PMID 9698072.
- Goenka S, Raman B, Ramakrishna T, Rao CM (2001). "Unfolding and refolding of a quinone oxidoreductase: alpha-crystallin, a molecular chaperone, assists its reactivation". Biochem. J. 359 (Pt 3): 547–56. doi:10.1042/0264-6021:3590547. PMC 1222175. PMID 11672428.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Bianco NR, Perry G, Smith MA, et al. (2004). "Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage". Mol. Endocrinol. 17 (7): 1344–55. doi:10.1210/me.2002-0382. PMID 12714703.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Vanjski linkovi uredi
- Lokacija ljudskog genoma CRYZ i stranica sa detaljima o genu CRYZ u UCSC Genome Browseru.