COL16A1
Kolagenski alfa-1(XVI) lanac jest protein koji je kod ljudi kodiran genom COL16A1 sa hromosoma 1.[5][6]
Amiokiselininska sekvenca
urediDužina polipeptidnog lanca je 1.604 aminokiseline, a molekulska težina 157.751 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MWVSWAPGLW | LLGLWATFGH | GANTGAQCPP | SQQEGLKLEH | SSSLPANVTG | ||||
| FNLIHRLSLM | KTSAIKKIRN | PKGPLILRLG | AAPVTQPTRR | VFPRGLPEEF | ||||
| ALVLTLLLKK | HTHQKTWYLF | QVTDANGYPQ | ISLEVNSQER | SLELRAQGQD | ||||
| GDFVSCIFPV | PQLFDLRWHK | LMLSVAGRVA | SVHVDCSSAS | SQPLGPRRPM | ||||
| RPVGHVFLGL | DAEQGKPVSF | DLQQVHIYCD | PELVLEEGCC | EILPAGCPPE | ||||
| TSKARRDTQS | NELIEINPQS | EGKVYTRCFC | LEEPQNSEVD | AQLTGRISQK | ||||
| AERGAKVHQE | TAADECPPCV | HGARDSNVTL | APSGPKGGKG | ERGLPGPPGS | ||||
| KGEKGARGND | CVRISPDAPL | QCAEGPKGEK | GESGALGPSG | LPGSTGEKGQ | ||||
| KGEKGDGGIK | GVPGKPGRDG | RPGEICVIGP | KGQKGDPGFV | GPEGLAGEPG | ||||
| PPGLPGPPGI | GLPGTPGDPG | GPPGPKGDKG | SSGIPGKEGP | GGKPGKPGVK | ||||
| GEKGDPCEVC | PTLPEGFQNF | VGLPGKPGPK | GEPGDPVPAR | GDPGIQGIKG | ||||
| EKGEPCLSCS | SVVGAQHLVS | STGASGDVGS | PGFGLPGLPG | RAGVPGLKGE | ||||
| KGNFGEAGPA | GSPGPPGPVG | PAGIKGAKGE | PCEPCPALSN | LQDGDVRVVA | ||||
| LPGPSGEKGE | PGPPGFGLPG | KQGKAGERGL | KGQKGDAGNP | GDPGTPGTTG | ||||
| RPGLSGEPGV | QGPAGPKGEK | GDGCTACPSL | QGTVTDMAGR | PGQPGPKGEQ | ||||
| GPEGVGRPGK | PGQPGLPGVQ | GPPGLKGVQG | EPGPPGRGVQ | GPQGEPGAPG | ||||
| LPGIQGLPGP | RGPPGPTGEK | GAQGSPGVKG | ATGPVGPPGA | SVSGPPGRDG | ||||
| QQGQTGLRGT | PGEKGPRGEK | GEPGECSCPS | QGDLIFSGMP | GAPGLWMGSS | ||||
| WQPGPQGPPG | IPGPPGPPGV | PGLQGVPGNN | GLPGQPGLTA | ELGSLPIEQH | ||||
| LLKSICGDCV | QGQRAHPGYL | VEKGEKGDQG | IPGVPGLDNC | AQCFLSLERP | ||||
| RAEEARGDNS | EGDPGCVGSP | GLPGPPGLPG | QRGEEGPPGM | RGSPGPPGPI | ||||
| GPPGFPGAVG | SPGLPGLQGE | RGLTGLTGDK | GEPGPPGQPG | YPGATGPPGL | ||||
| PGIKGERGYT | GSAGEKGEPG | PPGSEGLPGP | PGPAGPRGER | GPQGNSGEKG | ||||
| DQGFQGQPGF | PGPPGPPGFP | GKVGSPGPPG | PQAEKGSEGI | RGPSGLPGSP | ||||
| GPPGPPGIQG | PAGLDGLDGK | DGKPGLRGDP | GPAGPPGLMG | PPGFKGKTGH | ||||
| PGLPGPKGDC | GKPGPPGSTG | RPGAEGEPGA | MGPQGRPGPP | GHVGPPGPPG | ||||
| QPGPAGISAV | GLKGDRGATG | ERGLAGLPGQ | PGPPGHPGPP | GEPGTDGAAG | ||||
| KEGPPGKQGF | YGPPGPKGDP | GAAGQKGQAG | EKGRAGMPGG | PGKSGSMGPV | ||||
| GPPGPAGERG | HPGAPGPSGS | PGLPGVPGSM | GDMVNYDEIK | RFIRQEIIKM | ||||
| FDERMAYYTS | RMQFPMEMAA | APGRPGPPGK | DGAPGRPGAP | GSPGLPGQIG | ||||
| REGRQGLPGV | RGLPGTKGEK | GDIGIGIAGE | NGLPGPPGPQ | GPPGYGKMGA | ||||
| TGPMGQQGIP | GIPGPPGPMG | QPGKAGHCNP | SDCFGAMPME | QQYPPMKTMK | ||||
| GPFG |
Funkcija
urediOvaj gen kodira alfa lanac kolagena tipa XVI, člana porodice kolagena FACIT (kolageni povezani s fibrilima sa prekinutim spiralama). Članovi ove porodice kolagena u vezi su sa kolagenima koji formiraju vlakna, kao što su tip I i II, i služe za održavanje integriteta vanćelijskog matriksa. Visoki nivoi kolagena tipa XVI pronađeni su u fibroblastima i keratinocitima, te u glatkim mišićima i amnionu.[6]
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000084636 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040690 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Pan TC, Zhang RZ, Mattei MG, Timpl R, Chu ML (Aug 1992). "Cloning and chromosomal location of human alpha 1(XVI) collagen". Proc Natl Acad Sci U S A. 89 (14): 6565–9. Bibcode:1992PNAS...89.6565P. doi:10.1073/pnas.89.14.6565. PMC 49542. PMID 1631157.
- ^ a b "Entrez Gene: COL16A1 collagen, type XVI, alpha 1".
- ^ "UniProt, Q07092" (jezik: engleski). Pristupljeno 23. 11. 2021.
Dopunska literatura
uredi- Yamaguchi N, Kimura S, McBride OW, Hori H, Yamada Y, Kanamori T, Yamakoshi H, Nagai Y (1993). "Molecular cloning and partial characterization of a novel collagen chain, alpha 1(XVI), consisting of repetitive collagenous domains and cysteine-containing non-collagenous segments". J. Biochem. 112 (6): 856–63. doi:10.1093/oxfordjournals.jbchem.a123989. PMID 1284248.
- Ratzinger S, Grässel S, Dowejko A, Reichert TE, Bauer RJ (2011). "Induction of type XVI collagen expression facilitates proliferation of oral cancer cells". Matrix Biology. 30 (2): 118–25. doi:10.1016/j.matbio.2011.01.001. PMID 21251976.
- Sires UI, Dublet B, Aubert-Foucher E, van der Rest M, Welgus HG (1995). "Degradation of the COL1 domain of type XIV collagen by 92-kDa gelatinase". J. Biol. Chem. 270 (3): 1062–7. doi:10.1074/jbc.270.3.1062. PMID 7836360.
- Tillet E, Mann K, Nischt R, Pan TC, Chu ML, Timpl R (1995). "Recombinant analysis of human alpha 1 (XVI) collagen. Evidence for processing of the N-terminal globular domain". Eur. J. Biochem. 228 (1): 160–8. doi:10.1111/j.1432-1033.1995.tb20245.x. PMID 7882999.
- Grässel S, Timpl R, Tan EM, Chu ML (1997). "Biosynthesis and processing of type XVI collagen in human fibroblasts and smooth muscle cells". Eur. J. Biochem. 242 (3): 576–84. doi:10.1111/j.1432-1033.1996.0576r.x. PMID 9022684.
- Ratzinger S, Grässel S, Dowejko A, Reichert TE, Bauer RJ (mart 2011). "Induction of type XVI collagen expression facilitates proliferation of oral cancer cells". Matrix Biology. 30 (2): 118–25. doi:10.1016/j.matbio.2011.01.001. PMID 21251976.
- Kassner A, Hansen U, Miosge N, Reinhardt DP, Aigner T, Bruckner-Tuderman L, Bruckner P, Grässel S (2004). "Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils". Matrix Biol. 22 (2): 131–43. doi:10.1016/S0945-053X(03)00008-8. PMID 12782140.
- Kassner A, Tiedemann K, Notbohm H, Ludwig T, Mörgelin M, Reinhardt DP, Chu ML, Bruckner P, Grässel S (2004). "Molecular structure and interaction of recombinant human type XVI collagen". J. Mol. Biol. 339 (4): 835–53. doi:10.1016/j.jmb.2004.03.042. PMID 15165854.
- Eble JA, Kassner A, Niland S, Mörgelin M, Grifka J, Grässel S (2006). "Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains". J. Biol. Chem. 281 (35): 25745–56. doi:10.1074/jbc.M509942200. PMID 16754661.