Ćelijskopovršinski transmembranski glikoproteinski CD200 receptor 1 jest protein koji je kod ljudi kodiran genom CD200R1 sa hromosoma 3.[5][6][7] CD200R1 se eksprimira na površini mijeloidnih ćelija [8] i CD4+ T-ćelija.[9] Interragira sa CD200 transmembranskim glikoproteinom koji se može eksprimirati na različitim ćelijama uključujući neurone,[10] epithelial cells,[11] endotelne ćelije,[12] fibroblaste,[13] i limfoidne ćelije.[14]

CD200R1
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

4BFG, 4BFI

Identifikatori
AliasiCD200R1
Vanjski ID-jeviOMIM: 607546 MGI: 1889024 HomoloGene: 10957 GeneCards: CD200R1
Lokacija gena (čovjek)
Hromosom 3 (čovjek)
Hrom.Hromosom 3 (čovjek)[1]
Hromosom 3 (čovjek)
Genomska lokacija za CD200R1
Genomska lokacija za CD200R1
Bend3q13.2Početak112,921,205 bp[1]
Kraj112,975,103 bp[1]
Lokacija gena (miš)
Hromosom 16 (miš)
Hrom.Hromosom 16 (miš)[2]
Hromosom 16 (miš)
Genomska lokacija za CD200R1
Genomska lokacija za CD200R1
Bend16|16 B4Početak44,586,099 bp[2]
Kraj44,615,341 bp[2]
Ontologija gena
Molekularna funkcija GO:0001948, GO:0016582 vezivanje za proteine
immunoglobulin receptor activity
signaling receptor activity
glycosylated region protein binding
Ćelijska komponenta integral component of membrane
extracellular region
receptor complex
membrana
external side of plasma membrane
ćelijska membrana
cell surface
Biološki proces GO:0022415 viral process
regulation of immune response
GO:0072468 Transdukcija signala
heterotypic cell-cell adhesion
GO:0007243 intracellular signal transduction
Fc receptor signaling pathway
regulation of neuroinflammatory response
negative regulation of neuroinflammatory response
negative regulation of neuron death
negative regulation of macrophage migration
negative regulation of T cell migration
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_138806
NM_138939
NM_138940
NM_170780

NM_021325

RefSeq (bjelančevina)

NP_620161
NP_620385
NP_620386
NP_740750

NP_067300

Lokacija (UCSC)Chr 3: 112.92 – 112.98 MbChr 16: 44.59 – 44.62 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aktivacija CD200R1 regulira ekspresiju proupalnih molekula kao što je faktor tumorske nekroze (TNF-alfa),[15] interferoni i inducibilnadušik-oksidna sintetaza (iNOS).[16]

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 325 aminokiselina, а molekulska težina 36.620 Da.[17]

1020304050
MLCPWRTANLGLLLILTIFLVAASSSLCMDEKQITQNYSKVLAEVNTSWP
VKMATNAVLCCPPIALRNLIIITWEIILRGQPSCTKAYRKETNETKETNC
TDERITWVSRPDQNSDLQIRPVAITHDGYYRCIMVTPDGNFHRGYHLQVL
VTPEVTLFQNRNRTAVCKAVAGKPAAQISWIPEGDCATKQEYWSNGTVTV
KSTCHWEVHNVSTVTCHVSHLTGNKSLYIELLPVPGAKKSAKLYIPYIIL
TIIILTIVGFIWLLKVNGCRKYKLNKTESTPVVEEDEMQPYASYTEKNNP
LYDTTNKVKASEALQSEVDTDLHTL

Funkcija

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Ovaj gen kodira receptor za OX-2 membranski glikoprotein. I receptor i supstrat su glikoproteini ćelijske površine koji sadrže dva imunoglobulinska domena. Ovaj receptor je ograničen na površine loze mijeloidnih ćelija i interakcija receptor-supstrat može funkcionirati kao mijeloidni regulatorni signal. Studije srodnog gena na miševima sugeriraju da ova interakcija može kontrolirati mijeloidnu funkciju na tkivno specifičan način. Alternativna prerada ovog gena rezultira višestrukim varijantama transkripta.[7]

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163606 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022667 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AN (august 2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function". Immunity. 13 (2): 233–42. doi:10.1016/S1074-7613(00)00023-6. PMID 10981966.
  6. ^ Dick AD, Broderick C, Forrester JV, Wright GJ (januar 2001). "Distribution of OX2 antigen and OX2 receptor within retina". Investigative Ophthalmology & Visual Science. 42 (1): 170–6. PMID 11133863.
  7. ^ a b "Entrez Gene: CD200R1 CD200 receptor 1".
  8. ^ Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AN (august 2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function". Immunity. 13 (2): 233–42. doi:10.1016/s1074-7613(00)00023-6. PMID 10981966.
  9. ^ Caserta S, Nausch N, Sawtell A, Drummond R, Barr T, Macdonald AS, Mutapi F, Zamoyska R (2012). "Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells". PLOS ONE. 7 (4): e35466. Bibcode:2012PLoSO...735466C. doi:10.1371/journal.pone.0035466. PMC 3322173. PMID 22496920.
  10. ^ Costello DA, Lyons A, Denieffe S, Browne TC, Cox FF, Lynch MA (oktobar 2011). "Long term potentiation is impaired in membrane glycoprotein CD200-deficient mice: a role for Toll-like receptor activation". The Journal of Biological Chemistry. 286 (40): 34722–32. doi:10.1074/jbc.M111.280826. PMC 3186410. PMID 21835925.
  11. ^ Rosenblum MD, Olasz EB, Yancey KB, Woodliff JE, Lazarova Z, Gerber KA, Truitt RL (novembar 2004). "Expression of CD200 on epithelial cells of the murine hair follicle: a role in tissue-specific immune tolerance?". The Journal of Investigative Dermatology. 123 (5): 880–7. doi:10.1111/j.0022-202X.2004.23461.x. PMID 15482475.
  12. ^ Ko YC, Chien HF, Jiang-Shieh YF, Chang CY, Pai MH, Huang JP, Chen HM, Wu CH (januar 2009). "Endothelial CD200 is heterogeneously distributed, regulated and involved in immune cell-endothelium interactions". Journal of Anatomy. 214 (1): 183–95. doi:10.1111/j.1469-7580.2008.00986.x. PMC 2667927. PMID 19166481.
  13. ^ Ishibashi M, Neri S, Hashimoto H, Miyashita T, Yoshida T, Nakamura Y, Udagawa H, Kirita K, Matsumoto S, Umemura S, Yoh K, Niho S, Tsuboi M, Masutomi K, Goto K, Ochiai A, Ishii G (april 2017). "CD200-positive cancer associated fibroblasts augment the sensitivity of Epidermal Growth Factor Receptor mutation-positive lung adenocarcinomas to EGFR Tyrosine kinase inhibitors". Scientific Reports. 7: 46662. Bibcode:2017NatSR...746662I. doi:10.1038/srep46662. PMC 5399371. PMID 28429795.
  14. ^ Gentry M, Bodo J, Durkin L, Hsi ED (februar 2017). "Performance of a Commercially Available MAL Antibody in the Diagnosis of Primary Mediastinal Large B-Cell Lymphoma". The American Journal of Surgical Pathology. 41 (2): 189–194. doi:10.1097/PAS.0000000000000771. PMID 27879516. S2CID 25206581.
  15. ^ Pietilä M, Lehtonen S, Tuovinen E, Lähteenmäki K, Laitinen S, Leskelä HV, Nätynki A, Pesälä J, Nordström K, Lehenkari P (2012). "CD200 positive human mesenchymal stem cells suppress TNF-alpha secretion from CD200 receptor positive macrophage-like cells". PLOS ONE. 7 (2): e31671. Bibcode:2012PLoSO...731671P. doi:10.1371/journal.pone.0031671. PMC 3282758. PMID 22363701.
  16. ^ Carter DA, Dick AD (juni 2004). "CD200 maintains microglial potential to migrate in adult human retinal explant model". Current Eye Research. 28 (6): 427–36. doi:10.1080/02713680490503778. PMID 15512951. S2CID 20846500.
  17. ^ "UniProt, Q8TD46" (jezik: engleski). Pristupljeno 6. 11. 2021.

Dopunska literatura

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Vanjski linkovi

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Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.