AMOTL2

AMOTL2
Identifikatori
Aliasi	AMOTL2
Vanjski ID-jevi	OMIM: 614658 MGI: 1929286 HomoloGene: 9420 GeneCards: AMOTL2
Lokacija gena (čovjek)
Hrom.	Hromosom 3 (čovjek)
Kraj	134,375,479 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	102,610,617 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje identičnih proteina;
Ćelijska komponenta	• reciklirajući endosom; • citosol; • endozom; • apical plasma membrane; • GO:0016023 citoplazmatska vezikula; • bicellular tight junction;
Biološki proces	• Wnt-signalni put; • hippo signaling; • establishment of cell polarity involved in ameboidal cell migration; • actin cytoskeleton organization; • regulation of cell migration; • Angiogeneza;
	Izvori:Amigo / QuickGO
Ortolozi
	51421
	56332
	ENSG00000114019
	ENSMUSG00000032531
	Q9Y2J4
	Q8K371
	NM_001278683; NM_001278685; NM_016201; NM_001363943
	NM_019764
	NP_001265612; NP_001265614; NP_057285; NP_001350872
	NP_062738
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Angiomotinoliki protein 2 jest protein koji je kod ljudi kodiran genom AMOTL2 sa hromosoma 3.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 779 aminokiselina, а molekulska težina 85.764 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MRTLEDSSGT	VLHRLIQEQL	RYGNLTETRT	LLAIQQQALR	GGAGTGGTGS
PQASLEILAP	EDSQVLQQAT	RQEPQGQEHQ	GGENHLAENT	LYRLCPQPSK
GEELPTYEEA	KAHSQYYAAQ	QAGTRPHAGD	RDPRGAPGGS	RRQDEALREL
RHGHVRSLSE	RLLQLSLERN	GARAPSHMSS	SHSFPQLARN	QQGPPLRGPP
AEGPESRGPP	PQYPHVVLAH	ETTTAVTDPR	YRARGSPHFQ	HAEVRILQAQ
VPPVFLQQQQ	QYQYLQQSQE	HPPPPHPAAL	GHGPLSSLSP	PAVEGPVSAQ
ASSATSGSAH	LAQMEAVLRE	NARLQRDNER	LQRELESSAE	KAGRIEKLES
EIQRLSEAHE	SLTRASSKRE	ALEKTMRNKM	DSEMRRLQDF	NRDLRERLES
ANRRLASKTQ	EAQAGSQDMV	AKLLAQSYEQ	QQEQEKLERE	MALLRGAIED
QRRRAELLEQ	ALGNAQGRAA	RAEEELRKKQ	AYVEKVERLQ	QALGQLQAAC
EKREQLELRL	RTRLEQELKA	LRAQQRQAGA	PGGSSGSGGS	PELSALRLSE
QLREKEEQIL	ALEADMTKWE	QKYLEERAMR	QFAMDAAATA	AAQRDTTLIR
HSPQPSPSSS	FNEGLLTGGH	RHQEMESRLK	VLHAQILEKD	AVIKVLQQRS
RRDPGKAIQG	SLRPAKSVPS	VFAAAAAGTQ	GWQGLSSSER	QTADAPARLT
TDRAPTEEPV	VTAPPAAHAK	HGSRDGSTQT	EGPPDSTSTC	LPPEPDSLLG
CSSSQRAASL	DSVATSRVQD	LSDMVEILI

Funkcija

Angiomotin je protein koji veže angiostatin, cirkulirajući inhibitor stvaranja novih krvnih sudova (angiogeneza). Angiomotin posreduje angiostatinom u inhibiciji migracije endotelnih ćelija i formiranja mikrotubula in vitro. Protein koji je kodiran ovim genom povezan je sa angiomotinom i član je porodice proteinskih motina.^[5]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000114019 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032531 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: AMOTL2 angiomotin like 2".
^ "UniProt, Q9Y2J4" (jezik: engleski). Pristupljeno 6. 11. 2021.

Dopunska literatura

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
Bratt A, Wilson WJ, Troyanovsky B, et al. (2003). "Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains". Gene. 298 (1): 69–77. doi:10.1016/S0378-1119(02)00928-9. PMID 12406577.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Vanjski linkovi

Lokacija ljudskog genoma AMOTL2 i stranica sa detaljima o genu AMOTL2 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000114019 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032531 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: AMOTL2 angiomotin like 2".

[UniProt-6] "UniProt, Q9Y2J4" (jezik: engleski). Pristupljeno 6. 11. 2021.

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