ADI1

ADI1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4QGN
Identifikatori
Aliasi	ADI1
Vanjski ID-jevi	OMIM: 613400 MGI: 2144929 HomoloGene: 75081 GeneCards: ADI1
Lokacija gena (miš)
Hrom.	Hromosom 12 (miš)
Kraj	28,732,174 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • dioxygenase activity; • vezivanje iona metala; • oxidoreductase activity; • acireductone dioxygenase [iron(II)-requiring activity]; • iron ion binding;
Ćelijska komponenta	• citosol; • membrana; • ćelijska membrana; • jedro; • citoplazma;
Biološki proces	• methionine biosynthetic process; • cellular amino acid biosynthetic process; • L-methionine salvage from methylthioadenosine; • methionine metabolic process;
	Izvori:Amigo / QuickGO
Ortolozi
	55256
	104923
	n/a
	ENSMUSG00000020629
	Q9BV57
	Q99JT9
	NM_001306077; NM_018269
	NM_134052
	NP_001293006; NP_060739
	NP_598813
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

ADI1 je enzim 1,2-dihidroksi-3-keto-5-metoltiopenten- dioksdigenaza koja je kod ljudi kodirana istoimenim genom sa hromosoma 2.^[4]^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 179 aminokiselina, a molekulska težina 214,98 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MVQAWYMDDA	PGDPRQPHRP	DPGRPVGLEQ	LRRLGVLYWK	LDADKYENDP
ELEKIRRERN	YSWMDIITIC	KDKLPNYEEK	IKMFYEEHLH	LDDEIRYILD
GSGYFDVRDK	EDQWIRIFME	KGDMVTLPAG	IYHRFTVDEK	NYTKAMRLFV
GEPVWTAYNR	PADHFEARGQ	YVKFLAQTA

Funkcija

Enzim pripada porodici enzima koji vezuju metal aci-redukton dioksigenaza, uključenih u spasavanje metionina. Ovaj enzim može regulisati procesiuranje iRNK u jedru i može obavljati različite funkcije ovisno o svojoj lokalizaciji.

Klinički značaj

Bolesti povezane s ADI1 uključuju Klebsiella i refuzumsku bolest.

ADI1 je sposoban da podrži replikaciju virusa hepatitisa C u inače nepermisivnoj ćelijskoj liniji.^[8] Mouse hepatoma cells coexpressing human CD81 and ADI1/Sip-L supported HCV infection and replication.^[9] Human ADI1//Sip-L over-expression in 293 cells enhances cell entry but not replication of HCV.^[10]^[11]

Reference

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020629 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Uekita T, Gotoh I, Kinoshita T, Itoh Y, Sato H, Shiomi T, Okada Y, Seiki M (Mar 2004). "Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein-1 is a new member of the Cupin superfamily. A possible multifunctional protein acting as an invasion suppressor down-regulated in tumors". J Biol Chem. 279 (13): 12734–43. doi:10.1074/jbc.M309957200. PMID 14718544.
^ Hirano W, Gotoh I, Uekita T, Seiki M (Jun 2005). "Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1 (MTCBP-1) acts as an eukaryotic aci-reductone dioxygenase (ARD) in the methionine salvage pathway". Genes Cells. 10 (6): 565–74. doi:10.1111/j.1365-2443.2005.00859.x. PMID 15938715. S2CID 25563839.
^ "Entrez Gene: ADI1 acireductone dioxygenase 1".
^ "UniProt, Q9BV57" (jezik: engleski). Pristupljeno 10. 11. 2021.
^ Yeh CT, Lai HY, Chen TC, Chu CM, Liaw YF (2001). "Identification of a hepatic factor capable of supporting hepatitis C virus replication in a nonpermissive cell line". J. Virol. 75 (22): 11017–24. doi:10.1128/JVI.75.22.11017-11024.2001. PMC 114682. PMID 11602742.
^ Yeh CT, Lai HY, Yeh YJ, Cheng JC (2008). "Hepatitis C virus infection in mouse hepatoma cells co-expressing human CD81 and Sip-L". Biochem Biophys Res Commun. 372 (1): 157–61. doi:10.1016/j.bbrc.2008.05.018. PMID 18474223.
^ Cheng JC, Yeh YJ, Pai LM, Chang ML, Yeh CT (2009). "293 cells over-expressing human ADI1 and CD81 are permissive for serum-derived hepatitis C virus infection". J. Med. Virol. 81 (9): 1560–8. doi:10.1002/jmv.21495. PMID 19626614. S2CID 27972307.
^ Hwang DR, Lai HY, Chang ML, Hsu JT, Yeh CT (2005). "Emergence of mutation clusters in the HCV genome during sequential viral passages in Sip-L expressing cells". J Virol Methods. 129 (2): 170–7. doi:10.1016/j.jviromet.2005.05.026. PMID 16005986.

Dopunska literatura

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Yeh CT, Lai HY, Chen TC, Chu CM, Liaw YF (2001). "Identification of a hepatic factor capable of supporting hepatitis C virus replication in a nonpermissive cell line". J. Virol. 75 (22): 11017–24. doi:10.1128/JVI.75.22.11017-11024.2001. PMC 114682. PMID 11602742.
Yamada S, Ohira M, Horie H, Ando K, Takayasu H, Suzuki Y, Sugano S, Hirata T, Goto T, Matsunaga T, Hiyama E, Hayashi Y, Ando H, Suita S, Kaneko M, Sasaki F, Hashizume K, Ohnuma N, Nakagawara A (2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas". Oncogene. 23 (35): 5901–11. doi:10.1038/sj.onc.1207782. PMID 15221005.
Gotoh I, Uekita T, Seiki M (2007). "Regulated nucleo-cytoplasmic shuttling of human aci-reductone dioxygenase (hADI1) and its potential role in mRNA processing". Genes Cells. 12 (1): 105–17. doi:10.1111/j.1365-2443.2006.01035.x. PMID 17212658. S2CID 20464380.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Oram SW, Ai J, Pagani GM, Hitchens MR, Stern JA, Eggener S, Pins M, Xiao W, Cai X, Haleem R, Jiang F, Pochapsky TC, Hedstrom L, Wang Z (2007). "Expression and function of the human androgen-responsive gene ADI1 in prostate cancer". Neoplasia. 9 (8): 643–51. doi:10.1593/neo.07415. PMC 1950434. PMID 17786183.

Vanjski linovi

Lokacija ljudskog genoma ADI1 i stranica sa detaljima o genu ADI1 u UCSC Genome Browseru.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000020629 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14718544-4] Uekita T, Gotoh I, Kinoshita T, Itoh Y, Sato H, Shiomi T, Okada Y, Seiki M (Mar 2004). "Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein-1 is a new member of the Cupin superfamily. A possible multifunctional protein acting as an invasion suppressor down-regulated in tumors". J Biol Chem. 279 (13): 12734–43. doi:10.1074/jbc.M309957200. PMID 14718544.

[pmid15938715-5] Hirano W, Gotoh I, Uekita T, Seiki M (Jun 2005). "Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1 (MTCBP-1) acts as an eukaryotic aci-reductone dioxygenase (ARD) in the methionine salvage pathway". Genes Cells. 10 (6): 565–74. doi:10.1111/j.1365-2443.2005.00859.x. PMID 15938715. S2CID 25563839.

[entrez-6] "Entrez Gene: ADI1 acireductone dioxygenase 1".

[UniProt-7] "UniProt, Q9BV57" (jezik: engleski). Pristupljeno 10. 11. 2021.

[pmid11602742-8] Yeh CT, Lai HY, Chen TC, Chu CM, Liaw YF (2001). "Identification of a hepatic factor capable of supporting hepatitis C virus replication in a nonpermissive cell line". J. Virol. 75 (22): 11017–24. doi:10.1128/JVI.75.22.11017-11024.2001. PMC 114682. PMID 11602742.

[pmid18474223-9] Yeh CT, Lai HY, Yeh YJ, Cheng JC (2008). "Hepatitis C virus infection in mouse hepatoma cells co-expressing human CD81 and Sip-L". Biochem Biophys Res Commun. 372 (1): 157–61. doi:10.1016/j.bbrc.2008.05.018. PMID 18474223.

[pmid19626614-10] Cheng JC, Yeh YJ, Pai LM, Chang ML, Yeh CT (2009). "293 cells over-expressing human ADI1 and CD81 are permissive for serum-derived hepatitis C virus infection". J. Med. Virol. 81 (9): 1560–8. doi:10.1002/jmv.21495. PMID 19626614. S2CID 27972307.

[pmid16005986-11] Hwang DR, Lai HY, Chang ML, Hsu JT, Yeh CT (2005). "Emergence of mutation clusters in the HCV genome during sequential viral passages in Sip-L expressing cells". J Virol Methods. 129 (2): 170–7. doi:10.1016/j.jviromet.2005.05.026. PMID 16005986.

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