ACTR1B

ACTR1B
Identifikatori
Aliasi	ACTR1B
Vanjski ID-jevi	OMIM: 605144 MGI: 1917446 HomoloGene: 101541 GeneCards: ACTR1B
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	97,664,044 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	36,753,503 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• nucleotide binding; • GO:0001948, GO:0016582 vezivanje za proteine; • ATP binding; • cytoskeletal protein-membrane anchor activity;
Ćelijska komponenta	• citoplazma; • microtubule cytoskeleton; • citosol; • centrosom; • Egzosom; • citoskelet; • membrana; • dynactin complex; • centar organizacije mikrotubula; • extracellular region; • secretory granule lumen; • ficolin-1-rich granule lumen; • cell cortex region;
Biološki proces	• antigen processing and presentation of exogenous peptide antigen via MHC class II; • neutrophil degranulation; • establishment of mitotic spindle orientation; • nuclear migration along microtubule;
	Izvori:Amigo / QuickGO
Ortolozi
	10120
	226977
	ENSG00000115073
	ENSMUSG00000037351
	P42025
	Q8R5C5
	NM_005735
	NM_146107
	NP_005726
	NP_666219
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Beta-centraktin jest protein koji je kod ljudi kodiran genom ACTR1B sa hromosoma 2.^[5]^[6]^[7]

Aminokiselinska sekvenca

Ovaj gen kodira podjedinicu dinaktina od 42,3 kD, makromolekulski kompleks koji se sastoji od 10 podjedinica veličine od 22 do 150 kD. Dinaktin se vezuje za mikrotubule i citoplazmatski dinein. Uključen je u različite ćelijske funkcije, uključujući transport na relaciji ER – Golgijev aparat, centripetalnim pokretom lizosoma i endosoma, formiranja vretena, kretanja hromosoma, iedarnog pozicioniranja i aksonogeneze. Ova podjedinica, poput ACTR1A, je protein vezan za aktin. Ova dva proteina su jednake dužine i dijele 90% aminokiselinskog identiteta. Prisutni su u kompleksu dinaktina, u konstantnom omjeru od približno 1:15.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115073 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037351 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Clark SW, Staub O, Clark IB, Holzbaur EL, Paschal BM, Vallee RB, Meyer DI (maj 1995). "Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins". Mol Biol Cell. 5 (12): 1301–10. doi:10.1091/mbc.5.12.1301. PMC 301159. PMID 7696711.
^ Elsea SH, Clark IB, Juyal RC, Meyer DJ, Meyer DI, Patel PI (Jun 1999). "Assignment of beta-centractin (CTRN2) to human chromosome 2 bands q11.1→q11.2 with somatic cell hybrids and in situ hybridization". Cytogenet Cell Genet. 84 (1–2): 48–9. doi:10.1159/000015211. PMID 10343100. S2CID 83665096.
^ ^a ^b "Entrez Gene: ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)".
^ "UniProt, P42025" (jezik: engleski). Pristupljeno 15. 11. 2021.

Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Eckley DM, Schroer TA (2004). "Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1". Mol. Biol. Cell. 14 (7): 2645–54. doi:10.1091/mbc.E03-01-0049. PMC 165665. PMID 12857853.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Adams MD, Dubnick M, Kerlavage AR, et al. (1992). "Sequence identification of 2,375 human brain genes". Nature. 355 (6361): 632–4. Bibcode:1992Natur.355..632A. doi:10.1038/355632a0. PMID 1538749. S2CID 4234345.

ACTR1B detalji ljudskog genoma u UCSC Genome Browser.