ABLIM3

Aktin-vezujući LIM protein 3 jest protein koji je kod ljudi kodiran genom ABLIM3.

ABLIM3
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1UJS, 2DJ7
Identifikatori
Aliasi	ABLIM3
Vanjski ID-jevi	OMIM: 611305 MGI: 2442582 HomoloGene: 69175 GeneCards: ABLIM3
Lokacija gena (čovjek) Hrom. Hromosom 5 (čovjek) Bend 5q32 Početak 149,141,483 bp Kraj 149,260,542 bp
Lokacija gena (miš) Hrom. Hromosom 18 (miš) Bend 18|18 E1 Početak 61,932,463 bp Kraj 62,044,895 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • vezivanje iona metala • actin binding • GO:0001948, GO:0016582 vezivanje za proteine Ćelijska komponenta • citoplazma • stress fiber • lamellipodium Biološki proces • cytoskeleton organization • actin cytoskeleton organization • transcription, DNA-templated • lamellipodium assembly • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of protein targeting to mitochondrion • cilium assembly Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	22885	319713
Ensembl	ENSG00000173210	ENSMUSG00000032735
UniProt	O94929	Q69ZX8
RefSeq (mRNK)	NM_001301015 NM_001301018 NM_001301027 NM_001301028 NM_014945 NM_001345858 NM_001345859 NM_001345860 NM_001345861 NM_001370417 NM_001370418	NM_001164491 NM_198649 NM_001360868
RefSeq (bjelančevina)	NP_001287944 NP_001287947 NP_001287957 NP_001332787 NP_001332788 NP_001332789 NP_001332790 NP_055760 NP_001357346 NP_001357347	NP_001157963 NP_941051 NP_001347797
Lokacija (UCSC)	Chr 5: 149.14 – 149.26 Mb	Chr 18: 61.93 – 62.04 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 683 aminokiseline, а molekulska težina 77.802 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MNTSIPYQQN		PYNPRGSSNV		IQCYRCGDTC		KGEVVRVHNN		HFHIRCFTCQ
VCGCGLAQSG		FFFKNQEYIC		TQDYQQLYGT		RCDSCRDFIT		GEVISALGRT
YHPKCFVCSL		CRKPFPIGDK		VTFSGKECVC		QTCSQSMASS		KPIKIRGPSH
CAGCKEEIKH		GQSLLALDKQ		WHVSCFKCQT		CSVILTGEYI		SKDGVPYCES
DYHAQFGIKC		ETCDRYISGR		VLEAGGKHYH		PTCARCVRCH		QMFTEGEEMY
LTGSEVWHPI		CKQAARAEKK		LKHRRTSETS		ISPPGSSIGS		PNRVICAKVD
NEILNYKDLA		ALPKVKSIYE		VQRPDLISYE		PHSRYMSDEM		LERCGYGESL
GTLSPYSQDI		YENLDLRQRR		ASSPGYIDSP		TYSRQGMSPT		FSRSPHHYYR
SGPESGRSSP		YHSQLDVRSS		TPTSYQAPKH		FHIPAGDSNI		YRKPPIYKRH
GDLSTATKSK		TSEDISQTSK		YSPIYSPDPY		YASESEYWTY		HGSPKVPRAR
RFSSGGEEDD		FDRSMHKLQS		GIGRLILKEE		MKARSSSYAD		PWTPPRSSTS
SREALHTAGY		EMSLNGSPRS		HYLADSDPLI		SKSASLPAYR		RNGLHRTPSA
DLFHYDSMNA		VNWGMREYKI		YPYELLLVTT		RGRNRLPKDV		DRTRLERHLS
QEEFYQVFGM		TISEFDRLAL		WKRNELKKQA		RLF

Funkcija

LIM domen je dvostruka cinkoprstna struktura koja promovira interakcije protein-protein. Proteini domena LIM, poput ABLIM3, imaju ulogu u embrionskom razvoju, određivanju ćelijske loze i raku. Važan paralog ovog gena je LIMS1.

Klinički značaj

Bolesti povezane s ABLIM3 uključuju hepatoblastom, a među njegovim povezanim super-putevima su navođenje akson a i DCC posredovanu atraktivnu signalizaciu.

Dopunska literatura

• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Yamada S, Ohira M, Horie H, Ando K, Takayasu H, Suzuki Y, Sugano S, Hirata T, Goto T, Matsunaga T, Hiyama E, Hayashi Y, Ando H, Suita S, Kaneko M, Sasaki F, Hashizume K, Ohnuma N, Nakagawara A (Aug 2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas". Oncogene. 23 (35): 5901–5911. doi:10.1038/sj.onc.1207782. PMID 15221005.
• Zheng B, Wen JK, Han M, Zhou AR (Sep 2004). "hhLIM protein is involved in cardiac hypertrophy". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1690 (1): 1–10. doi:10.1016/j.bbadis.2004.04.009. PMID 15337165.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Krupp M, Weinmann A, Galle PR, Teufel A (Jan 2006). "Actin binding LIM protein 3 (abLIM3)". International Journal of Molecular Medicine. 17 (1): 129–33. doi:10.3892/ijmm.17.1.129. PMID 16328021.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Barrientos T, Frank D, Kuwahara K, Bezprozvannaya S, Pipes GC, Bassel-Duby R, Richardson JA, Katus HA, Olson EN, Frey N (Mar 2007). "Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin". The Journal of Biological Chemistry. 282 (11): 8393–8403. doi:10.1074/jbc.M607549200. PMID 17194709.

Vanjski linkovi

• Lokacija ljudskog genoma ABLIM3 i stranica sa detaljima o genu ABLIM3 u UCSC Genome Browseru.