CD200R1

CD200R1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4BFG, 4BFI
Identifikatori
Aliasi	CD200R1
Vanjski ID-jevi	OMIM: 607546 MGI: 1889024 HomoloGene: 10957 GeneCards: CD200R1
Lokacija gena (čovjek)
Hrom.	Hromosom 3 (čovjek)
Kraj	112,975,103 bp
Lokacija gena (miš)
Hrom.	Hromosom 16 (miš)
Kraj	44,615,341 bp
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • immunoglobulin receptor activity; • signaling receptor activity; • glycosylated region protein binding;
Ćelijska komponenta	• integral component of membrane; • extracellular region; • receptor complex; • membrana; • external side of plasma membrane; • ćelijska membrana; • cell surface;
Biološki proces	• GO:0022415 viral process; • regulation of immune response; • GO:0072468 Transdukcija signala; • heterotypic cell-cell adhesion; • GO:0007243 intracellular signal transduction; • Fc receptor signaling pathway; • regulation of neuroinflammatory response; • negative regulation of neuroinflammatory response; • negative regulation of neuron death; • negative regulation of macrophage migration; • negative regulation of T cell migration;
	Izvori:Amigo / QuickGO
Ortolozi
	131450
	57781
	ENSG00000163606
	ENSMUSG00000022667
	Q8TD46
	Q9ES57
	NM_138806; NM_138939; NM_138940; NM_170780
	NM_021325
	NP_620161; NP_620385; NP_620386; NP_740750
	NP_067300
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Ćelijskopovršinski transmembranski glikoproteinski CD200 receptor 1 jest protein koji je kod ljudi kodiran genom CD200R1 sa hromosoma 3.^[5]^[6]^[7] CD200R1 se eksprimira na površini mijeloidnih ćelija ^[8] i CD4+ T-ćelija.^[9] Interragira sa CD200 transmembranskim glikoproteinom koji se može eksprimirati na različitim ćelijama uključujući neurone,^[10] epithelial cells,^[11] endotelne ćelije,^[12] fibroblaste,^[13] i limfoidne ćelije.^[14]

Aktivacija CD200R1 regulira ekspresiju proupalnih molekula kao što je faktor tumorske nekroze (TNF-alfa),^[15] interferoni i inducibilnadušik-oksidna sintetaza (iNOS).^[16]

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 325 aminokiselina, а molekulska težina 36.620 Da.^[17]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MLCPWRTANL	GLLLILTIFL	VAASSSLCMD	EKQITQNYSK	VLAEVNTSWP
VKMATNAVLC	CPPIALRNLI	IITWEIILRG	QPSCTKAYRK	ETNETKETNC
TDERITWVSR	PDQNSDLQIR	PVAITHDGYY	RCIMVTPDGN	FHRGYHLQVL
VTPEVTLFQN	RNRTAVCKAV	AGKPAAQISW	IPEGDCATKQ	EYWSNGTVTV
KSTCHWEVHN	VSTVTCHVSH	LTGNKSLYIE	LLPVPGAKKS	AKLYIPYIIL
TIIILTIVGF	IWLLKVNGCR	KYKLNKTEST	PVVEEDEMQP	YASYTEKNNP
LYDTTNKVKA	SEALQSEVDT	DLHTL

Funkcija uredi

Ovaj gen kodira receptor za OX-2 membranski glikoprotein. I receptor i supstrat su glikoproteini ćelijske površine koji sadrže dva imunoglobulinska domena. Ovaj receptor je ograničen na površine loze mijeloidnih ćelija i interakcija receptor-supstrat može funkcionirati kao mijeloidni regulatorni signal. Studije srodnog gena na miševima sugeriraju da ova interakcija može kontrolirati mijeloidnu funkciju na tkivno specifičan način. Alternativna prerada ovog gena rezultira višestrukim varijantama transkripta.^[7]

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163606 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022667 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AN (august 2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function". Immunity. 13 (2): 233–42. doi:10.1016/S1074-7613(00)00023-6. PMID 10981966.
^ Dick AD, Broderick C, Forrester JV, Wright GJ (januar 2001). "Distribution of OX2 antigen and OX2 receptor within retina". Investigative Ophthalmology & Visual Science. 42 (1): 170–6. PMID 11133863.
^ ^a ^b "Entrez Gene: CD200R1 CD200 receptor 1".
^ Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AN (august 2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function". Immunity. 13 (2): 233–42. doi:10.1016/s1074-7613(00)00023-6. PMID 10981966.
^ Caserta S, Nausch N, Sawtell A, Drummond R, Barr T, Macdonald AS, Mutapi F, Zamoyska R (2012). "Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells". PLOS ONE. 7 (4): e35466. Bibcode:2012PLoSO...735466C. doi:10.1371/journal.pone.0035466. PMC 3322173. PMID 22496920.
^ Costello DA, Lyons A, Denieffe S, Browne TC, Cox FF, Lynch MA (oktobar 2011). "Long term potentiation is impaired in membrane glycoprotein CD200-deficient mice: a role for Toll-like receptor activation". The Journal of Biological Chemistry. 286 (40): 34722–32. doi:10.1074/jbc.M111.280826. PMC 3186410. PMID 21835925.
^ Rosenblum MD, Olasz EB, Yancey KB, Woodliff JE, Lazarova Z, Gerber KA, Truitt RL (novembar 2004). "Expression of CD200 on epithelial cells of the murine hair follicle: a role in tissue-specific immune tolerance?". The Journal of Investigative Dermatology. 123 (5): 880–7. doi:10.1111/j.0022-202X.2004.23461.x. PMID 15482475.
^ Ko YC, Chien HF, Jiang-Shieh YF, Chang CY, Pai MH, Huang JP, Chen HM, Wu CH (januar 2009). "Endothelial CD200 is heterogeneously distributed, regulated and involved in immune cell-endothelium interactions". Journal of Anatomy. 214 (1): 183–95. doi:10.1111/j.1469-7580.2008.00986.x. PMC 2667927. PMID 19166481.
^ Ishibashi M, Neri S, Hashimoto H, Miyashita T, Yoshida T, Nakamura Y, Udagawa H, Kirita K, Matsumoto S, Umemura S, Yoh K, Niho S, Tsuboi M, Masutomi K, Goto K, Ochiai A, Ishii G (april 2017). "CD200-positive cancer associated fibroblasts augment the sensitivity of Epidermal Growth Factor Receptor mutation-positive lung adenocarcinomas to EGFR Tyrosine kinase inhibitors". Scientific Reports. 7: 46662. Bibcode:2017NatSR...746662I. doi:10.1038/srep46662. PMC 5399371. PMID 28429795.
^ Gentry M, Bodo J, Durkin L, Hsi ED (februar 2017). "Performance of a Commercially Available MAL Antibody in the Diagnosis of Primary Mediastinal Large B-Cell Lymphoma". The American Journal of Surgical Pathology. 41 (2): 189–194. doi:10.1097/PAS.0000000000000771. PMID 27879516. S2CID 25206581.
^ Pietilä M, Lehtonen S, Tuovinen E, Lähteenmäki K, Laitinen S, Leskelä HV, Nätynki A, Pesälä J, Nordström K, Lehenkari P (2012). "CD200 positive human mesenchymal stem cells suppress TNF-alpha secretion from CD200 receptor positive macrophage-like cells". PLOS ONE. 7 (2): e31671. Bibcode:2012PLoSO...731671P. doi:10.1371/journal.pone.0031671. PMC 3282758. PMID 22363701.
^ Carter DA, Dick AD (juni 2004). "CD200 maintains microglial potential to migrate in adult human retinal explant model". Current Eye Research. 28 (6): 427–36. doi:10.1080/02713680490503778. PMID 15512951. S2CID 20846500.
^ "UniProt, Q8TD46" (jezik: engleski). Pristupljeno 6. 11. 2021.

Dopunska literatura uredi

Matsue H (decembar 2005). "CD 200-mediated regulation of skin immunity". The Journal of Investigative Dermatology. 125 (6): x–xi. doi:10.1111/j.0022-202X.2005.23978.x. PMID 16354172.
Shiratori I, Yamaguchi M, Suzukawa M, Yamamoto K, Lanier LL, Saito T, Arase H (oktobar 2005). "Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200". Journal of Immunology. 175 (7): 4441–9. doi:10.4049/jimmunol.175.7.4441. PMID 16177086.
Cherwinski HM, Murphy CA, Joyce BL, Bigler ME, Song YS, Zurawski SM, Moshrefi MM, Gorman DM, Miller KL, Zhang S, Sedgwick JD, Phillips JH (februar 2005). "The CD200 receptor is a novel and potent regulator of murine and human mast cell function". Journal of Immunology. 174 (3): 1348–56. doi:10.4049/jimmunol.174.3.1348. PMID 15661892.
Zhang Z, Henzel WJ (oktobar 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Foster-Cuevas M, Wright GJ, Puklavec MJ, Brown MH, Barclay AN (juli 2004). "Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor". Journal of Virology. 78 (14): 7667–76. doi:10.1128/JVI.78.14.7667-7676.2004. PMC 434103. PMID 15220441.
Karteris E, Chen J, Randeva HS (april 2004). "Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system". The Journal of Clinical Endocrinology and Metabolism. 89 (4): 1957–62. doi:10.1210/jc.2003-031778. PMID 15070969.
Wright GJ, Cherwinski H, Foster-Cuevas M, Brooke G, Puklavec MJ, Bigler M, Song Y, Jenmalm M, Gorman D, McClanahan T, Liu MR, Brown MH, Sedgwick JD, Phillips JH, Barclay AN (septembar 2003). "Characterization of the CD200 receptor family in mice and humans and their interactions with CD200". Journal of Immunology. 171 (6): 3034–46. doi:10.4049/jimmunol.171.6.3034. PMID 12960329.
Vieites JM, de la Torre R, Ortega MA, Montero T, Peco JM, Sánchez-Pozo A, Gil A, Suárez A (juni 2003). "Characterization of human cd200 glycoprotein receptor gene located on chromosome 3q12-13". Gene. 311: 99–104. doi:10.1016/S0378-1119(03)00562-6. PMID 12853143.

Vanjski linkovi uredi

CD200R1 protein, human na US National Library of Medicine Medical Subject Headings (MeSH)
Lokacija ljudskog genoma CD200R1 i stranica sa detaljima o genu CD200R1 u UCSC Genome Browseru.
Lokacija ljudskog genoma HCRTR2 i stranica sa detaljima o genu HCRTR2 u UCSC Genome Browseru.

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163606 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022667 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10981966-5] Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AN (august 2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function". Immunity. 13 (2): 233–42. doi:10.1016/S1074-7613(00)00023-6. PMID 10981966.

[pmid11133863-6] Dick AD, Broderick C, Forrester JV, Wright GJ (januar 2001). "Distribution of OX2 antigen and OX2 receptor within retina". Investigative Ophthalmology & Visual Science. 42 (1): 170–6. PMID 11133863.

[entrez-7] "Entrez Gene: CD200R1 CD200 receptor 1".

[8] Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AN (august 2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function". Immunity. 13 (2): 233–42. doi:10.1016/s1074-7613(00)00023-6. PMID 10981966.

[9] Caserta S, Nausch N, Sawtell A, Drummond R, Barr T, Macdonald AS, Mutapi F, Zamoyska R (2012). "Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells". PLOS ONE. 7 (4): e35466. Bibcode:2012PLoSO...735466C. doi:10.1371/journal.pone.0035466. PMC 3322173. PMID 22496920.

[10] Costello DA, Lyons A, Denieffe S, Browne TC, Cox FF, Lynch MA (oktobar 2011). "Long term potentiation is impaired in membrane glycoprotein CD200-deficient mice: a role for Toll-like receptor activation". The Journal of Biological Chemistry. 286 (40): 34722–32. doi:10.1074/jbc.M111.280826. PMC 3186410. PMID 21835925.

[11] Rosenblum MD, Olasz EB, Yancey KB, Woodliff JE, Lazarova Z, Gerber KA, Truitt RL (novembar 2004). "Expression of CD200 on epithelial cells of the murine hair follicle: a role in tissue-specific immune tolerance?". The Journal of Investigative Dermatology. 123 (5): 880–7. doi:10.1111/j.0022-202X.2004.23461.x. PMID 15482475.

[12] Ko YC, Chien HF, Jiang-Shieh YF, Chang CY, Pai MH, Huang JP, Chen HM, Wu CH (januar 2009). "Endothelial CD200 is heterogeneously distributed, regulated and involved in immune cell-endothelium interactions". Journal of Anatomy. 214 (1): 183–95. doi:10.1111/j.1469-7580.2008.00986.x. PMC 2667927. PMID 19166481.

[13] Ishibashi M, Neri S, Hashimoto H, Miyashita T, Yoshida T, Nakamura Y, Udagawa H, Kirita K, Matsumoto S, Umemura S, Yoh K, Niho S, Tsuboi M, Masutomi K, Goto K, Ochiai A, Ishii G (april 2017). "CD200-positive cancer associated fibroblasts augment the sensitivity of Epidermal Growth Factor Receptor mutation-positive lung adenocarcinomas to EGFR Tyrosine kinase inhibitors". Scientific Reports. 7: 46662. Bibcode:2017NatSR...746662I. doi:10.1038/srep46662. PMC 5399371. PMID 28429795.

[14] Gentry M, Bodo J, Durkin L, Hsi ED (februar 2017). "Performance of a Commercially Available MAL Antibody in the Diagnosis of Primary Mediastinal Large B-Cell Lymphoma". The American Journal of Surgical Pathology. 41 (2): 189–194. doi:10.1097/PAS.0000000000000771. PMID 27879516. S2CID 25206581.

[15] Pietilä M, Lehtonen S, Tuovinen E, Lähteenmäki K, Laitinen S, Leskelä HV, Nätynki A, Pesälä J, Nordström K, Lehenkari P (2012). "CD200 positive human mesenchymal stem cells suppress TNF-alpha secretion from CD200 receptor positive macrophage-like cells". PLOS ONE. 7 (2): e31671. Bibcode:2012PLoSO...731671P. doi:10.1371/journal.pone.0031671. PMC 3282758. PMID 22363701.

[16] Carter DA, Dick AD (juni 2004). "CD200 maintains microglial potential to migrate in adult human retinal explant model". Current Eye Research. 28 (6): 427–36. doi:10.1080/02713680490503778. PMID 15512951. S2CID 20846500.

[UniProt-17] "UniProt, Q8TD46" (jezik: engleski). Pristupljeno 6. 11. 2021.

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