ZSCAN4

Cinkov prst i protein 4 sa domenom SCAN je protein koji je kod ljudi kodiran genom ZSCAN4.

ZSCAN4
Identifikatori
Aliasi	ZSCAN4
Vanjski ID-jevi	OMIM: 613419 MGI: 3708485 HomoloGene: 138332 GeneCards: ZSCAN4
Lokacija gena (čovjek) Hrom. Hromosom 19 (čovjek) Bend 19q13.43 Početak 57,668,935 bp Kraj 57,679,152 bp
Lokacija gena (miš) Hrom. Hromosom 7 (miš) Bend 7|7 A1 Početak 11,131,842 bp Kraj 11,136,245 bp
Ontologija gena Molekularna funkcija • vezivanje sa DNK • vezivanje iona metala • nucleic acid binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • Telomera • hromosom • jedro Biološki proces • telomere maintenance via telomere lengthening • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • negative regulation of mitotic recombination • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	201516	665902
Ensembl	ENSG00000180532	ENSMUSG00000070828
UniProt	Q8NAM6	Q3URS2
RefSeq (mRNK)	NM_152677 NM_001384833	NM_001110316
RefSeq (bjelančevina)	NP_689890	NP_001103786
Lokacija (UCSC)	Chr 19: 57.67 – 57.68 Mb	Chr 7: 11.13 – 11.14 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MALDLRTIFQ		CEPSENNLGS		ENSAFQQSQG		PAVQREEGIS		EFSRMVLNSF
QDSNNSYARQ		ELQRLYRIFH		SWLQPEKHSK		DEIISLLVLE		QFMIGGHCND
KASVKEKWKS		SGKNLERFIE		DLTDDSINPP		ALVHVHMQGQ		EALFSEDMPL
RDVIVHLTKQ		VNAQTTREAN		MGTPSQTSQD		TSLETGQGYE		DEQDGWNSSS
KTTRVNENIT		NQGNQIVSLI		IIQEENGPRP		EEGGVSSDNP		YNSKRAELVT
ARSQEGSING		ITFQGVPMVM		GAGCISQPEQ		SSPESALTHQ		SNEGNSTCEV
HQKGSHGVQK		SYKCEECPKV		FKYLCHLLAH		QRRHRNERPF		VCPECQKGFF
QISDLRVHQI		IHTGKKPFTC		SMCKKSFSHK		TNLRSHERIH		TGEKPYTCPF
CKTSYRQSST		YHRHMRTHEK		ITLPSVPSTP		EAS

Funkcija

Gen ZSCAN4 kodira protein uključen u održavanje telomeraa+ i sa ključnom ulogom u kritičnoj osobini miša matičnih ćelija embriona, unatoč ćelijskom starenju i održavajući normalan kariotip za mnoge diobe ćelija u kulturi tkiva.

Dopunaka literatura

• Lee K, Gollahon LS (2014). "Zscan4 interacts directly with human Rap1 in cancer cells regardless of telomerase status". Cancer Biol. Ther. 15 (8): 1094–105. doi:10.4161/cbt.29220. PMC 4119077. PMID 24840609.
• Lee K, Gollahon LS (2015). "ZSCAN4 and TRF1: A functionally indirect interaction in cancer cells independent of telomerase activity". Biochem. Biophys. Res. Commun. 466 (4): 644–9. doi:10.1016/j.bbrc.2015.09.107. PMID 26403970.
• Ishiguro KI, Nakatake Y, Chikazawa-Nohtomi N, Kimura H, Akiyama T, Oda M, Ko SB, Ko MS (2017). "Expression analysis of the endogenous Zscan4 locus and its coding proteins in mouse ES cells and preimplantation embryos". In Vitro Cell. Dev. Biol. Anim. 53 (2): 179–190. doi:10.1007/s11626-016-0097-y. PMC 5311086. PMID 27699651.