ZNF16

Protein cinkovog prsta 16 je protein koji je kod ljudi kodiran genom ZNF16.

ZNF16
Identifikatori
Aliasi	ZNF16
Vanjski ID-jevi	OMIM: 601262 HomoloGene: 56008 GeneCards: ZNF16
Lokacija gena (čovjek) Hrom. Hromosom 8 (čovjek) Bend 8q24.3 Početak 144,930,358 bp Kraj 144,950,888 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • vezivanje sa DNK • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje iona metala • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • jedro • Jedarce Biološki proces • positive regulation of cell cycle phase transition • positive regulation of kinase activity • ćelijski ciklus • negative regulation of apoptotic process • GO:0009373 regulation of transcription, DNA-templated • positive regulation of megakaryocyte differentiation • positive regulation of cell division • positive regulation of erythrocyte differentiation • transcription, DNA-templated • positive regulation of cell population proliferation • cellular response to sodium dodecyl sulfate • Ćelijska dioba • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	7564	n/a
Ensembl	ENSG00000170631	n/a
UniProt	P17020	n/a
RefSeq (mRNK)	NM_001029976 NM_006958	n/a
RefSeq (bjelančevina)	NP_001025147 NP_008889	n/a
Lokacija (UCSC)	Chr 8: 144.93 – 144.95 Mb	n/a
PubMed pretraga		n/a
Wikipodaci
Pogledaj/uredi – čovjek

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 682 aminokiseline, а molekulska težina 76.472 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MPSLRTRREE		AEMELSVPGP		SPWTPAAQAR		VRDAPAVTHP		GSAACGTPCC
SDTELEAICP		HYQQPDCDTR		TEDKEFLHKE		DIHEDLESQA		EISENYAGDV
SQVPELGDLC		DDVSERDWGV		PEGRRLPQSL		SQEGDFTPAA		MGLLRGPLGE
KDLDCNGFDS		RFSLSPNLMA		CQEIPTEERP		HPYDMGGQSF		QHSVDLTGHE
GVPTAESPLI		CNECGKTFQG		NPDLIQRQIV		HTGEASFMCD		DCGKTFSQNS
VLKNRHRSHM		SEKAYQCSEC		GKAFRGHSDF		SRHQSHHSSE		RPYMCNECGK
AFSQNSSLKK		HQKSHMSEKP		YECNECGKAF		RRSSNLIQHQ		RIHSGEKPYV
CSECGKAFRR		SSNLIKHHRT		HTGEKPFECG		ECGKAFSQSA		HLRKHQRVHT
GEKPYECNDC		GKPFSRVSNL		IKHHRVHTGE		KPYKCSDCGK		AFSQSSSLIQ
HRRIHTGEKP		HVCNVCGKAF		SYSSVLRKHQ		IIHTGEKPYR		CSVCGKAFSH
SSALIQHQGV		HTGDKPYACH		ECGKTFGRSS		NLILHQRVHT		GEKPYECTEC
GKTFSQSSTL		IQHQRIHNGL		KPHECNQCGK		AFNRSSNLIH		HQKVHTGEKP
YTCVECGKGF		SQSSHLIQHQ		IIHTGERPYK		CSECGKAFSQ		RSVLIQHQRI
HTGVKPYDCA		ACGKAFSQRS		KLIKHQLIHT		RE

Funkcija

Protein kodiran ovim genom sadrži C2H2 tip cinkovog prsta, pa može funkcionirati kao transkripcijski faktor. Ovaj gen se nalazi u regionu blizu ZNF7/KOX4, gena koji također kodira protein cinkovog prsta, na hromosomu 8. Identificirane su dvije alternativno prerađene varijante, koje kodiraju isti protein.

Dopunska literatura

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Dreier B, Segal DJ, Barbas CF (2000). "Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains". J. Mol. Biol. 303 (4): 489–502. doi:10.1006/jmbi.2000.4133. PMID 11054286.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Rousseau-Merck MF, Duro D, Berger R, Thiesen HJ (1995). "Chromosomal localization of two KOX zinc finger genes on chromosome bands 7q21-q22". Ann. Genet. 38 (2): 81–4. PMID 7486829.
• Thiesen HJ (1991). "Multiple genes encoding zinc finger domains are expressed in human T cells". New Biol. 2 (4): 363–74. PMID 2288909.