ZHX2

ZHX2
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2DMP, 3NAU
Identifikatori
Aliasi	ZHX2
Vanjski ID-jevi	OMIM: 609185 MGI: 2683087 HomoloGene: 8968 GeneCards: ZHX2
Lokacija gena (čovjek)
Hrom.	Hromosom 8 (čovjek)
Kraj	122,974,510 bp
Lokacija gena (miš)
Hrom.	Hromosom 15 (miš)
Kraj	57,703,228 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • vezivanje sa DNK; • GO:0001948, GO:0016582 vezivanje za proteine; • protein homodimerization activity; • GO:0001106 transcription corepressor activity; • vezivanje iona metala; • vezivanje identičnih proteina; • protein heterodimerization activity; • nucleic acid binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• jedro; • nukleoplazma; • citosol; • ćelijska membrana;
Biološki proces	• GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • GO:0045996 negative regulation of transcription, DNA-templated; • GO:0009373 regulation of transcription, DNA-templated; • GO:1901227 negative regulation of transcription by RNA polymerase II; • mRNA catabolic process; • negative regulation of neuron differentiation; • somatic stem cell population maintenance; • transcription, DNA-templated; • retinal bipolar neuron differentiation; • nervous system development; • Ćelijska diferencijacija;
	Izvori:Amigo / QuickGO
Ortolozi
	22882
	387609
	ENSG00000178764
	ENSMUSG00000071757
	Q9Y6X8
	Q8C0C0
	NM_014943; NM_001362797
	NM_199449
	NP_055758; NP_001349726
	NP_955520
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 2 cinkovog prsta i homeoboksova je protein koji je kod ljudi kodiran genom ZHX2.^[5]^[6]^[7]

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 837 aminokiselina, а molekulska težina Da. 92 307^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MASKRKSTTP	CMVRTSQVVE	QDVPEEVDRA	KEKGIGTPQP	DVAKDSWAAE
LENSSKENEV	IEVKSMGESQ	SKKLQGGYEC	KYCPYSTQNL	NEFTEHVDMQ
HPNVILNPLY	VCAECNFTTK	KYDSLSDHNS	KFHPGEANFK	LKLIKRNNQT
VLEQSIETTN	HVVSITTSGP	GTGDSDSGIS	VSKTPIMKPG	KPKADAKKVP
KKPEEITPEN	HVEGTARLVT	DTAEILSRLG	GVELLQDTLG	HVMPSVQLPP
NINLVPKVPV	PLNTTKYNSA	LDTNATMINS	FNKFPYPTQA	ELSWLTAASK
HPEEHIRIWF	ATQRLKHGIS	WSPEEVEEAR	KKMFNGTIQS	VPPTITVLPA
QLAPTKVTQP	ILQTALPCQI	LGQTSLVLTQ	VTSGSTTVSC	SPITLAVAGV
TNHGQKRPLV	TPQAAPEPKR	PHIAQVPEPP	PKVANPPLTP	ASDRKKTKEQ
IAHLKASFLQ	SQFPDDAEVY	RLIEVTGLAR	SEIKKWFSDH	RYRCQRGIVH
ITSESLAKDQ	LAIAASRHGR	TYHAYPDFAP	QKFKEKTQGQ	VKILEDSFLK
SSFPTQAELD	RLRVETKLSR	REIDSWFSER	RKLRDSMEQA	VLDSMGSGKK
GQDVGAPNGA	LSRLDQLSGA	QLTSSLPSPS	PAIAKSQEQV	HLLRSTFART
QWPTPQEYDQ	LAAKTGLVRT	EIVRWFKENR	CLLKTGTVKW	MEQYQHQPMA
DDHGYDAVAR	KATKPMAESP	KNGGDVVPQY	YKDPKKLCEE	DLEKLVTRVK
VGSEPAKDCL	PAKPSEATSD	RSEGSSRDGQ	GSDENEESSV	VDYVEVTVGE
EDAISDRSDS	WSQAAAEGVS	ELAESDSDCV	PAEAGQA

Funkcija uredi

Članovi porodice gena cinkovih prstiju i homeoboksova su jedarni homodimerni transkripcijski represori koji stupaju u interakciju s A podjedinicom jedarnog faktora-Y (NF-YA) i sadrže dva C2H2-tipa cinkovih prstiju i pet homeoboksnih domena koji vežu DNK. Ovaj gen kodira člana 2 ove genske porodice. Osim što stvara homodimere, ovaj protein heterodimerizuje s članom 1 iz porodice cinkovih prstiju i homeoboksova.^[7]

Također pogledajte uredi

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000178764 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000071757 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (maj 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
^ Kawata H, Yamada K, Shou Z, Mizutani T, Yazawa T, Yoshino M, Sekiguchi T, Kajitani T, Miyamoto K (Jul 2003). "Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor". Biochem J. 373 (Pt 3): 747–57. doi:10.1042/BJ20030171. PMC 1223552. PMID 12741956.
^ ^a ^b "Entrez Gene: ZHX2 zinc fingers and homeoboxes 2".
^ "UniProt, Q9Y6X8" (jezik: engleski). Pristupljeno 22. 9. 2021.

Dopunska literatura uredi

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kawata H, Yamada K, Shou Z, et al. (2004). "The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3". Gene. 323: 133–40. doi:10.1016/j.gene.2003.09.013. PMID 14659886.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
de Andrade TG, Peterson KR, Cunha AF, et al. (2006). "Identification of novel candidate genes for globin regulation in erythroid cells containing large deletions of the human beta-globin gene cluster". Blood Cells Mol. Dis. 37 (2): 82–90. doi:10.1016/j.bcmd.2006.07.003. PMID 16952470.
Liu G, Clement LC, Kanwar YS, et al. (2007). "ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome". J. Biol. Chem. 281 (51): 39681–92. doi:10.1074/jbc.M606664200. PMID 17056598.
Hu S, Zhang M, Lv Z, et al. (2007). "Expression of zinc-fingers and homeoboxes 2 in hepatocellular carcinogenesis: a tissue microarray and clinicopathological analysis". Neoplasma. 54 (3): 207–11. PMID 17447851.

Vanjski linkovi uredi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000178764 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000071757 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10048485-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (maj 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.

[pmid12741956-6] Kawata H, Yamada K, Shou Z, Mizutani T, Yazawa T, Yoshino M, Sekiguchi T, Kajitani T, Miyamoto K (Jul 2003). "Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor". Biochem J. 373 (Pt 3): 747–57. doi:10.1042/BJ20030171. PMC 1223552. PMID 12741956.

[entrez-7] "Entrez Gene: ZHX2 zinc fingers and homeoboxes 2".

[UniProt-8] "UniProt, Q9Y6X8" (jezik: engleski). Pristupljeno 22. 9. 2021.

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