WARS

Citoplazmatska triptofanil-tRNK sintetaza je enzim koji je kosd ljudi kodiran genom WARS.

WARS
Identifikatori
Aliasi
Vanjski ID-jevi	GeneCards: [1]
Ortolozi
Vrste	Čovjek	Miš
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n a	n/a
RefSeq (mRNK)	n/a	n/a
RefSeq (bjelančevina)	n/a	n/a
Lokacija (UCSC)	n/a	n/a
PubMed pretraga	n/a	n/a
Wikipodaci
Pogledaj/uredi – čovjek

Aminoacil-tRNK sintetaze kataliziraju aminoacilaciju tRNK pomoću njihove srodne aminokiseline. Zbog njihove središnje uloge u povezivanju aminokiselina s nukleotidnim tripletima sadržanim u tRNK, smatra se da su aminoacil-tRNK sintetaza među prvim proteinima, koje su se pojavile u evoluciji. Postoje dva oblika triptofanil-tRNA sintetaze, citoplazmatski oblik, zvani WARS i mitohondrijski oblik, zvani WARS2. Triptofanil-tRNA sintetaza (WARS) katalizira aminoacilaciju tRNK (trp) sa triptofanom i indukuje je interferon. Triptofanil-tRNA sintetaza pripada porodici tRNK-sintetaza klase I. Za ovaj gen pronađene su četiri varijante transkripta koje kodiraju dvije različite izoforme.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 471 aminokiselina, a molekulska težina 53.165 Da.

10		20		30		40		50
MPNSEPASLL		ELFNSIATQG		ELVRSLKAGN		ASKDEIDSAV		KMLVSLKMSY
KAAAGEDYKA		DCPPGNPAPT		SNHGPDATEA		EEDFVDPWTV		QTSSAKGIDY
DKLIVRFGSS		KIDKELINRI		ERATGQRPHH		FLRRGIFFSH		RDMNQVLDAY
ENKKPFYLYT		GRGPSSEAMH		VGHLIPFIFT		KWLQDVFNVP		LVIQMTDDEK
YLWKDLTLDQ		AYSYAVENAK		DIIACGFDIN		KTFIFSDLDY		MGMSSGFYKN
VVKIQKHVTF		NQVKGIFGFT		DSDCIGKISF		PAIQAAPSFS		NSFPQIFRDR
TDIQCLIPCA		IDQDPYFRMT		RDVAPRIGYP		KPALLHSTFF		PALQGAQTKM
SASDPNSSIF		LTDTAKQIKT		KVNKHAFSGG		RDTIEEHRQF		GGNCDVDVSF
MYLTFFLEDD		DKLEQIRKDY		TSGAMLTGEL		KKALIEVLQP		LIAEHQARRK
EVTDEIVKEF		MTPRKLSFDF		Q

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Dopunska literatura

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